Riassunto
I fattori neurotrofici (FN) (dal greco trofein concernente il nutrimento) sono molecole solubili di natura proteica che, secrete da cellule di vario tipo (neuroni, glia, cellule emopoietiche, ecc.), favoriscono la sopravvivenza dei neuroni (cellule bersaglio, target cells). Essi agiscono su specifici recettori di membrana posti sulle cellule bersaglio generando segnali intracellulari in grado di regolare i processi di sopravvivenza e di morte.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Letture consigliate
Nerve growth factor
Abbott A (2009) One hundred years of Rita. Nat 458:564–567
Luo W, Wickramasinghe SR, Savitt JM et al (2007) A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron 54:739–754
Wiesmann C, Ultsch MH, Bass SH, de Vos AM (1999) Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Nature 401:184–188
Brain-derived neurotrophic factor
Barde YA, Edgar D, Thoenen H (1982) Purification of a new neurotrophic factor from mammalian brain. EMBO J 1:549–553
Volpicelli F, Caiazzo M, Greco D et al (2007) Bdnf gene is a downstream target of Nurr1 transcription factor in rat midbrain neurons in vitro. J Neurochem 102:441–453
Zuccato C, Cattaneo E (2009) Brain-derived neurotrophic factor in neurodegenerative diseases. Nat Rev Neurol 5:311–322
Zuccato C, Ciammola A, Rigamonti D et al (2001) Loss of huntingtin-mediated BDNF gene transcription in Huntington’s disease. Science 293:493–498
Ciliary neurotrophic factor
Lambert PD, Anderson KD, Sleeman MW et al (2001) Ciliary neurotrophic factor activates lep-tin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. Proc Natl Acad Sci USA 98:4652–4657
Manthorpe M, Skaper S, Adler R et al (1980) Cholinergic neuronotrophic factors: fractionation properties of an extract from selected chick embryonic eye tissues. J Neurochem 34:69–75
Schuste B, et al (2003) Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF. J Biol Chem 278:9528–9535
Glial-derived neurotrophic factor
Airaksinen MS, Titievsky A, Saarma M (1999) GDNF family neurotrophic factor signaling: four masters, one servant? Mol Cell Neurosci 13:313–325
Consales C, Volpicelli F, Greco D et al (2007) GDNF signaling in embryonic midbrain neurons in vitro. Brain Res 1159:28–39
Paratcha G, Ledda F, Ibáñez CF (2003) The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands. Cell 113:867–879
Pascual A, Hidalgo-Figueroa M, Piruat JI et al (2008) Absolute requirement of GDNF for adult catecholaminergic neuron survival. Nat Neurosci 11:755–761
Cerebral dopamine neurotrophic factor e Mesencephalic astrocyte-derived neurotrophic factor
Lindholm P, Voutilainen MH, Laurén J et al (2007) Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature 448:73–77
Palgi M, Lindström R, Peränen J et al (2009) Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons. Proc Natl Acad Sci 106:2429–2434
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag Italia
About this chapter
Cite this chapter
D’Amato, L.C., di Porzio, U. (2011). I fattori di crescita neurotrofici. In: Introduzione alla neurobiologia. Springer, Milano. https://doi.org/10.1007/978-88-470-1944-7_6
Download citation
DOI: https://doi.org/10.1007/978-88-470-1944-7_6
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-1943-0
Online ISBN: 978-88-470-1944-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)