Current Approach to Chronic and Acute Airway Diseases

  • Philippe A. Grenier
  • Tomas Franquet


Multidetector computed tomography (MDCT) using thin collimation during a single breath hold has become the best imaging technique for assessing airway diseases. Volumetric high-resolution data sets provide precise morphologic evaluation of both proximal and distal airways [1]. The different CT patterns and their main causes are reported in Tables 1–5. The different diseases involving the airways, which are presented in this course, include neoplastic and nonneoplastic tracheobronchial diseases, bronchiectasis and small airway diseases, asthma, and chronic obstructive pulmonary disease (COPD).


Chronic Obstructive Pulmonary Disease Adenoid Cystic Carcinoma Airway Wall Obliterative Bronchiolitis Bronchial Wall 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Grenier PA, Beigelman-Aubry C, Fetita C et al (2002) New frontiers in CT imaging of airway disease. Eur Radiol 12:1022–1044PubMedCrossRefGoogle Scholar
  2. 2.
    Beigelman-Aubry C, Brillet PY, Grenier PA (2009) Multidetector CT of the airways: Technique and normal results. Radiol Clin North Am 47:185–201PubMedCrossRefGoogle Scholar
  3. 3.
    Boiselle PM, Lynch DA (2008) CT of the airways. Humana, New York, NYCrossRefGoogle Scholar
  4. 4.
    Ferretti GR, Bithigoffer C, Righini CA et al (2009) Imaging of tumors of the trachea and central bronchi. Radiol Clin North Am 47:227–241PubMedCrossRefGoogle Scholar
  5. 5.
    Naidich DP, Webb WR, Grenier PA et al (2005) Imaging of the airways. Functional and radiological correlations. Lippincott Williams & Wilkins, Philadelphia, PAGoogle Scholar
  6. 6.
    Grenier PA, Beigelman-Aubry C, Brillet PY (2009) Nonneoplastic tracheal and bronchial stenoses. Radiol Clin North Am 47:243–260PubMedCrossRefGoogle Scholar
  7. 7.
    Baroni RH, Feller-Kopman D, Nishino M et al (2005) Tracheobronchomalacia: comparison between end-expiratory and dynamic expiratory CT for evaluation of central airway collapse. Radiology 235:635–641PubMedCrossRefGoogle Scholar
  8. 8.
    Lee EY, Litmanovich D, Boiselle PM (2009) Multidetector CT evaluation of tracheobronchomalacia. Radiol Clin North Am 47:261–269PubMedCrossRefGoogle Scholar
  9. 9.
    Desir A, Ghaye B (2009) Congenital abnormalities of intrathoracic airways. Radiol Clin North Am 47:203–225PubMedCrossRefGoogle Scholar
  10. 10.
    Roberts HR, Wells AU, Milne DG et al (2005). Airflow obstruction in bronchiectasis: correlation between computed tomography features and pulmonary function tests. Thorax 55:198–204CrossRefGoogle Scholar
  11. 11.
    Ooi GC, Khong PL, Chang-Yeung M et al (2002) High-resolution CT quantification of bronchiectasis: clinical and functional correlation. Radiology 225:663–672PubMedCrossRefGoogle Scholar
  12. 12.
    Sheehan RE, Wells AU, Copley SJ et al (2002) Comparison of serial computed tomography and functional change in bronchiectasis. Eur Respir J 20:581–587PubMedCrossRefGoogle Scholar
  13. 13.
    Dodd JD, Souza CA, Müller NL (2006) Conventional high-resolution CT versus helical high-resolution MDCT in the detection of bronchiectasis. AJR Am J Roentgenol 187:414–420PubMedCrossRefGoogle Scholar
  14. 14.
    Chooi WK, Mattews S, Bull MJ et al (2003) Multislice helical CT: the value of multiplanar image reconstruction in assessment of the bronchi and small airways disease. Br J Radiol 76:536–540PubMedCrossRefGoogle Scholar
  15. 15.
    Remy-Jardin M, Amara A, Campistron P et al (2003) Diagnosis of bronchiectasis with multislice spiral CT: accuracy of 3-mm-thick structured sections. Eur Radiol 13:1165–1171PubMedGoogle Scholar
  16. 16.
    Sung YM, Lee KS, CA YI (2003) Additional coronal images using low-milliamperage multidetector-row computed tomography: effectiveness in the diagnosis of bronchiectasis. J Comput Assist Tomogr 27:490–495PubMedCrossRefGoogle Scholar
  17. 17.
    Franquet T, Müller NL (2003) Disorders of the small airways: high-resolution computed tomographic features. Semin Respir Crit Care Med 24:437–444PubMedCrossRefGoogle Scholar
  18. 18.
    Pipavath SNJ, Stern EJ (2009) Imaging of small airway disease (SAD). Radiol Clin North Am 47:307–316PubMedCrossRefGoogle Scholar
  19. 19.
    Franquet T, Müller NL, Oikonomou A, Flint JD (2004) Aspergillus infection of the airways: computed tomography and pathologic findings. J Comput Assist Tomogr 28:10–16PubMedCrossRefGoogle Scholar
  20. 20.
    Woods AQ, Lynch DA (2009) Asthma: an imaging update. Radiol Clin North Am 47:317–329PubMedCrossRefGoogle Scholar
  21. 21.
    Niimi A, Matsumoto H, Amitani R et al (2000) Airway wall thickness in asthma assessed by computed tomography. Relations to clinical indices. Am J Respir Crit Care Med 162:1518–1523PubMedCrossRefGoogle Scholar
  22. 22.
    Aysola RS, Hoffman EA, Gierada D et al (2008) Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology. Chest 134:1183–1191PubMedCrossRefGoogle Scholar
  23. 23.
    Laurent F, Latrabe V, Raherison C et al (2000) Functional significance of air trapping detected in moderate asthma. Eur Radiol 10:1404–1410PubMedCrossRefGoogle Scholar
  24. 24.
    Tunon-de-Lara JM, Laurent F, Giraud V et al (2007) Air trapping in mild and moderate asthma: effect of inhaled corticosteroids. J Allergy Clin Immunol 119:583–590PubMedCrossRefGoogle Scholar
  25. 25.
    Ley-Zaporozhan J, Kauczor HU (2009) Imaging of airways: chronic obstructive pulmonary disease. Radiol Clin North Am 47:331–342PubMedCrossRefGoogle Scholar
  26. 26.
    Brillet PY, Fetita CI, Saragaglia A et al (2008) Investigation of airway using MDCT for visual and quantitative assessment in COPD patients. Int J Chron Obstruct Pulm Dis 3:97–107Google Scholar
  27. 27.
    Nakano Y, Wong JC, de Jong PA et al (2005) The prediction of small airway dimensions using computed tomography. Am J Respir Crit Care Med 171:142–146PubMedCrossRefGoogle Scholar
  28. 28.
    Aziz ZA, Wells AU, Desai SR et al (2005) Functional impairment in emphysema: contribution of airway abnormalities and distribution of parenchymal disease. AJR Am J Roentgenol 185:1509–1515PubMedCrossRefGoogle Scholar
  29. 29.
    Berger P, Perot V, Desbarats P et al (2005) Airway wall thickness in cigarette smokers: quantitative thin-section CT assessment. Radiology 235:1055–1064PubMedCrossRefGoogle Scholar
  30. 30.
    Sverzellati N, Ingegnoli A, Calabro E et al (2010) Bronchial diverticula in smokers on thin-section CT. Eur Radiol 20:88–94PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2011

Authors and Affiliations

  • Philippe A. Grenier
    • 1
  • Tomas Franquet
    • 2
  1. 1.Department of RadiologyUniversity Pierre & Marie Curie — Hospital Pitié-SalpetrièreParisFrance
  2. 2.Department of RadiologyHospital de St. PauBarcelonaSpain

Personalised recommendations