Myocardial Perfusion Imaging with SPECT-CT

  • Philipp A. Kaufmann


Noninvasive cardiac imaging has experienced substantial advances, including the introduction of coronary computed tomography angiography (CCTA). Invasive coronary angiography has remained the anatomic standard of reference but is associated with a nonnegligible periprocedural morbidity and mortality rate that suggests confining its use to patients who will benefit from a subsequent revascularization procedure. Many parameters beyond the simple quantification of luminal narrowing and which therefore cannot be fully assessed with luminology will determine whether a given lesion is hemodynamically relevant and causes stress-induced ischemia. Myocardial perfusion scintigraphy by single photon emission CT (SPECT) is the most widely used and best established noninvasive tool for diagnosing ischemic heart disease. Although positron emission tomography (PET) offers a higher accuracy than SPECT, its use is often limited to large centers. Latest results suggest a great potential of cardiac hybrid imaging, allowing a comprehensive evaluation of coronary artery disease (CAD) by combining both morphological and functional information after fusing SPECT with CCTA. Hybrid imaging with SPECT-CT can provide entirely noninvasively unique information that helps improve diagnostic assessment and risk stratification and also impacts decision making with regard to revascularization in patients with CAD.


Myocardial Perfusion Imaging Coronary Compute Tomography Angiography Invasive Coronary Angiography Myocardial Perfusion Scintigraphy Cadmium Zinc Telluride 
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Copyright information

© Springer-Verlag Italia 2011

Authors and Affiliations

  • Philipp A. Kaufmann
    • 1
  1. 1.Department of Radiology, Cardiac ImagingUniversity Hospital ZurichZurichSwitzerland

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