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Current Concepts in Diagnosis and Staging of Lung Cancer

  • José S. Vilar
  • Jeremy J. Erasmus

Abstract

The main issues related to thoracic imaging in evaluating patients with lung cancer are: detection, characterization, staging, treatment assessment, and monitoring for tumor recurrence after treatment. In this chapter we review the diagnosis and staging of non-small-cell lung cancer (NSCLC) with an emphasis on the seventh edition of the tumor node metastasis (TNM) staging system. The advantages and proper use of imaging techniques are stressed, especially in relation to the specifc situation of the patient and the needs of the clinician.

Keywords

Positron Emission Tomography Positron Emission Tomography Imaging Pulmonary Nodule Tumor Node Metastasis Malignant Pleural Effusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Shah PK, Austin JH, White CS et al (2003) Missed non small cell lung cancers: radiographic findings of potentially resectable lesions evident only in retrospect. Radiology 226:235–241PubMedCrossRefGoogle Scholar
  2. 2.
    Girvin F, Ko JP (2008) Pulmonary nodules: detection, assessment, and CAD. AJR Am J Roentgenol 191:1057–1069PubMedCrossRefGoogle Scholar
  3. 3.
    MacMahon H, Austin JH, Gamsu G et al (2005) Guidelines for management of small pulmonary nodules detected on CT scans: a statement from the Fleischner Society. Radiology 237:395–400PubMedCrossRefGoogle Scholar
  4. 4.
    Nathan MH, Collins VP, Adams RA (1962) Differentiation of benign and malignant pulmonary nodules by growth rate. Radiology 79:221–232PubMedGoogle Scholar
  5. 5.
    Beigelman-Aubry C, Hill C, Grenier PA (2007) Management of incidentally discovered pulmonary nodule. Eur Radiol 17:449–466PubMedCrossRefGoogle Scholar
  6. 6.
    Mahoney MC, Shipley RT, Corcoran HL, Dickson BA (1990) CT demonstration of calcification in carcinoma of the lung. AJR Am J Roentgenol 154:255–258PubMedCrossRefGoogle Scholar
  7. 7.
    Henschke CI, Yankelevitz DF, Mirtcheva R et al (2002) CT screening for lung cancer: frequency and significance of part-solid and nonsolid nodules. AJR Am J Roentgenol 178:1053–1057PubMedCrossRefGoogle Scholar
  8. 8.
    Kui M, Templeton PA, White CS et al (1996) Evaluation of the air bronchogram sign on CT in solitary pulmonary lesions. J Comput Assist Tomogr 20:983–986PubMedCrossRefGoogle Scholar
  9. 9.
    Swensen SJ, Silverstein MD, Ilstrup DM et al (l997) The probability of malignancy in solitary pulmonary nodules: application to small radiologically indeterminate nodules. Arch Intern Med 157:849–855CrossRefGoogle Scholar
  10. 10.
    Schaefer JS, Vollmar J, Schick F et al (2004) Solitary pulmonary nodules: dynamic contrast-enhanced MR imaging — perfusion differences in malignant and benign lesions. Radiology 232:544–553PubMedCrossRefGoogle Scholar
  11. 11.
    Gould MK, Maclean CC, Kuschner WG et al (2001) Accuracy of positron emission tomography for diagnosis of pulmonary nodules and mass lesions: a meta-analysis. JAMA 285:914–924PubMedCrossRefGoogle Scholar
  12. 12.
    Cetinkaya E, Turna A, Yildiz P et al (2002) Comparison of clinical and surgical-pathologic staging of the patients with non-small cell lung carcinoma. Eur J Cardiothorac Surg 6:1000–1005CrossRefGoogle Scholar
  13. 13.
    Maziak DE, Darling GE, Inculet RI et al (2009) Positron emission tomography in staging early lung cancer. Ann Intern Med 151:221–228PubMedCrossRefGoogle Scholar
  14. 14.
    Goldstraw P, Crowley JJ (2006) The International Association for the Study of Lung Cancer: International Staging Project on Lung Cancer. J Thorac Oncol 1:281–286CrossRefGoogle Scholar
  15. 15.
    Munden R, Swisher S, Stevens C, Stewart D (2005) Imaging of the patient with non-small cell lung cancer. Radiology 237: 803–818PubMedCrossRefGoogle Scholar
  16. 16.
    Bruzzi J, Komaki R, Walsh GL et al (2008) Imaging of non-small cell lung cancer of the superior sulcus: Part 2: initial staging and assessment of resectability and therapeutic response. RadioGraphics 28:561–572PubMedCrossRefGoogle Scholar
  17. 17.
    Gerbaudo VH, Julius B (2007) Anatomo-metabolic characteristics of atelectasis in F-8 FDG-PET/CT imaging. Eur J Radiol 64:401–405PubMedCrossRefGoogle Scholar
  18. 18.
    Schaffler GJ, Wolf G, Schoellnast H et al (2004) Non small cell lung cancer: evaluation of pleural abnormalities on CT scans with 18F FDG PET. Radiology 231:858–865PubMedCrossRefGoogle Scholar
  19. 19.
    Rusch VW, Crowley J, Giroux DJ et al (2007) The IASLC Lung Cancer Staging Project: proposals for the revision of the N descriptors in the forthcoming seventh edition of the TNM classification for lung cancer. J Thorac Oncol 2:603–612PubMedCrossRefGoogle Scholar
  20. 20.
    Peter Goldstraw (ed) (2009) The IASLC Staging Reference Card in Thoracic Oncology. Editorial Rx Press, Orange Park, FLGoogle Scholar
  21. 21.
    McLoud TC, Bourgouin PM, Greenberg RW et al (1992) Bronchogenic carcinoma: analysis of staging in the mediastinum with CT by correlative lymph node mapping and sampling. Radiology 182:319–323PubMedGoogle Scholar
  22. 22.
    Birim O, Kappetein AP, Stijnen T, Bogers AJ (2005) Meta-analysis of positron emission tomographic and computed tomographic imaging in detecting mediastinal lymph node metastases in nonsmall cell lung cancer. Ann Thorac Surg 79:375–382PubMedCrossRefGoogle Scholar
  23. 23.
    Antoch G, Stattaus J, Nemat AT et al (2003) Non-small cell lung cancer: dual-modality PET/CT in preoperative staging. Radiology 229:526–533PubMedCrossRefGoogle Scholar
  24. 24.
    Postmus PE, Brambilla E, Chansky K et al (2007) The IASLC Lung Cancer Staging Project: proposals for revision of the M descriptors in the forthcoming (seventh) edition of the TNM classification of lung cancer. J Thorac Oncol 2:686–693PubMedCrossRefGoogle Scholar
  25. 25.
    Mayo-Smith WW, Boland GW, Noto RB, Lee MJ (2001) State-of-the-art adrenal imaging. Radiographics 21:995–1012PubMedGoogle Scholar
  26. 26.
    Reed CE, Harpole DH, Posther KE et al (2003) Results of the American College of Surgeons Oncology Group Z0050 trial: the utility of positron emission tomography in staging potentially operable non-small cell lung cancer. J Thorac Cardiovasc Surg 126:1943–1951PubMedCrossRefGoogle Scholar
  27. 27.
    van Tinteren H, Hoekstra OS, Smit EF et al (2002) Effectiveness of positron emission tomography in the preoperative assessment of patients with suspected non-small-cell lung cancer: the PLUS multicentre randomised trial. Lancet 359: 1388–1393PubMedCrossRefGoogle Scholar
  28. 28.
    MacManus MP, Hicks RJ, Matthews JP et al (2001) High rate of detection of unsuspected distant metastases by PET in apparent stage III non-small-cell lung cancer: implications for radical radiation therapy. Int J Radiat Oncol Biol Phys 50: 287–293PubMedCrossRefGoogle Scholar
  29. 29.
    Viney RC, Boyer MJ, King MT et al (2004) Randomized controlled trial of the role of positron emission tomography in the management of stage I and II non-small-cell lung cancer. J Clin Oncol 22:2357–2362PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2011

Authors and Affiliations

  • José S. Vilar
    • 1
  • Jeremy J. Erasmus
    • 2
  1. 1.Hospital Universitario Dr. PesetValenciaSpain
  2. 2.Division of Diagnostic ImagingMD Anderson Cancer CenterHoustonUSA

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