How Vulvodynia Originates: the Pathophysiology of Vulvar Pain

  • Alessandra Graziottin
  • Filippo Murina


Vulvodynia is a complex syndrome of vulvar pain with sexual dysfunction and psychological disability. Its etiology remains elusive but several lines of investigation support a neuropathic etiopathogenesis for the disease. The manifestation of vulvodynia may be caused by more than one factor and may vary in each patient.


Mast Cell Nerve Grow Factor Neuropathic Pain Irritable Bowel Syndrome Dorsal Horn 
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Copyright information

© Springer-Verlag Italia 2011

Authors and Affiliations

  • Alessandra Graziottin
    • 1
    • 2
  • Filippo Murina
    • 3
  1. 1.Center of Gynecology and Medical SexologyH. San Raffaele ResnatiMilanItaly
  2. 2.Graziottin Foundation for the cure and care of pain in womenItaly
  3. 3.Department of Vulvar Disease V. Buzzi Hospital Obstetrics and Gynecological ClinicUniversity of MilanMilanItaly

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