Abstract
Hepatic resection is the treatment of choice for colorectal liver metastases, with 5-year survival rates now approaching 60%. Postoperative morbidity and mortality are constantly decreasing. In particular, 90-day postoperative mortality has been reported in several series to be less than 1%. Several prognostic factors of poor outcome have been recognized but, at present, most of them cannot be used to select patients for resection. Future identification of molecular factors may aid in the prediction of prognosis and help to improve the selection of those patients most likely to benefit from surgery.
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References
Simmonds PC, Primrose J N, Colquitt JL et al (2006) Surgical resection of hepatic metastases from colorectal cancer: A systematic review of published studies. Br J Cancer 94:982–999
Scheele J, Stang R, Altendorf-Hofmann A, Paul M (1995). Resection of colorectal liver metastases. World J Surg 19:59–71
Nordlinger B, Guiguet M, Vaillant JC et al (1996) Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Francaise de Chirurgie. Cancer 77:1254–1262
Fong Y, Fortner J, Sun RL et al (1999) Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg 230:309–318
Minagawa M, Makuuchi M, Torzilli G et al (2000) Extension of the frontiers of surgical indications in the treatment of liver metastases from colorectal cancer: long-term results. Ann Surg 231:487–99
Choti MA, Sitzmann JV, Tiburi MF et al (2002) Trends in long-term survival following liver resection for hepatic colorectal metastases. Ann Surg 235:759–766
Ercolani G, Grazi GL, Ravaioli M et al (2002) Liver resection for multiple colorectal metastases. Influence of parenchymal involvement and total tumor volume, vs number or location, on long-term survival. Arch Surg 137:1187–1192
Adam R, Delvart V, Pascal G et al (2004) Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy. A model to predict long-term survival. Ann Surg 240: 644–658
Fernandez FG, Drebin JA, Linehan DC et al (2004) Five-year survival after resection of hepatic metastases from colorectal cancer in patients screened by positron emission tomography with F-18 fluorodeoxyglucose (FDG-PET). Ann Surg 240:438–447
Jonas S, Thelen A, Benckert C et al (2007) Extended resections of liver metastases from colorectal cancer. World J Surg 31:511–521
Malik HZ, Prasad R, Halazun KJ et al (2007) Preoperative prognostic score for predicting survival after hepatic resection for colorectal liver metastases. Ann Surg 246:806–814
Tomlinson JS, Jarnagin WR, DeMatteo RP et al (2007) Actual 10-year survival after resection of colorectal liver metastases defines cure. J Clin Oncol 25:4575–4580
Are C, Gonen M, Zazzali K et al (2007) The impact of margins on outcome after hepatic resection for colorectal metastasis. Ann Surg 246:295–300
Rees M, Tekkis PP, Welsh FKS et al (2008) Evaluation of long-term survival after hepatic resection for metastatic colorectal cancer. A multifactorial model of 929 patients. Ann Surg 247: 125–135
Gold JS, Are C, Kornprat P et al (2008) Liver metastases from colorectal cancer is associated with improved mortality without change in oncologic outcome. Trends in treatment over time in 440 patients. Ann Surg 247:109–117
House MG, Ito H, Gönen M et al (2010) Survival after hepatic resection for metastatic colorectal cancer: trends in outcomes for 1,600 patients during two decades at a single institution. J Am Coll Surg 210:744–754
Abdalla EK, Vauthey JN, Ellis LM et al (2004) Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg 239:818–825
Pawlik TM, Scoggins CR, Zorzi D et al (2005) Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases. Ann Surg 241:715–724
Viganò L, Ferrero A, Lo Tesoriere R et al (2008) Liver surgery for colorectal metastases: results after 10 years of follow-up. Long-term survivors, late recurrences, and prognostic role of morbidity. Ann Surg Oncol 15:2458–2464
de Jong MC, Pulitano C, Ribero D et al (2009) Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis. An international multi-institutional analysis of 1669 patients. Ann Surg 250:440–448
Mullen JT, Ribero D, Reddy S et al (2007) Hepatic insufficiency and mortality in 1059 noncirrhotic patients undergoing major hepatectomy. J Am Coll Surg 204:854–864
Capussotti L, Viganò L, Giuliante F et al (2009) Liver dysfunction and sepsis determine operative mortality after liver resection. Br J Surg 96:88–94
Jarnagin WR, Gonen M, Fong Y et al (2002) Improvement in perioperative outcome after hepatic resection. Analysis of 1,803 consecutive cases over the past decade. Ann Surg 236:397–407
Scheele J, Altendorf-Hofmann A (1999) Resection of colorectal liver metastases. Langenbeck’s Arch Surg 384:313–327
Fortner JG, Silva JS, Golbey RB et al (1984) Multivariate analysis of a personal series of 247 consecutive patients with liver metastases from colorectal cancer. I. Treatment by hepatic resection. Ann Surg 199:306–316
Ohlsson B, Stenram U, Tranberg KG (1998) Resection of colorectal metastases: 25-year experience. World J Surg 22:268–276
Cady B, Jenkins RL, Steele GD Jr et al (1998) Surgical margin in hepatic resection for colorectal metastasis: a critical and improvable determinant of outcome. Ann Surg 227:566–571
Ambiru S, Miyazaki M, Isono T et al (1999) Hepatic resection for colorectal metastases. Analysis of prognostic factors. Dis Colon Rectum 42:632–639
Iwatsuki S, Dvorchik I, Madariaga JR et al (1999) Hepatic resection for metastatic colorectal adenocarcinoma: a proposal of a prognostic scoring system. J Am Coll Surg 189:291–299
Ueno H, Mochizuki H, Hatsuse K et al (2000) Indicators for treatment strategies of colorectal liver metastases. Ann Surg 231:59–66
Lise M, Bacchetti S, Da Pian P et al (2001) Patterns of recurrence after resection of colorectal liver metastases: prediction by models of outcome analysis. World J Surg 25:638–644
Nagashima I, Takada T, Matsuda K et al (2004) A new scoring system to classify patients with colorectal liver metastases: proposal of criteria to select candidates for hepatic resection. J Hepatobiliary Pancreat Surg 11:79–83
Schindl M, Wigmore SJ, Currie EJ et al (2005) Prognostic scoring in colorectal cancer liver metastases. Development and validation. Arch Surg 140:183–189
Wei AC, Greig PD, Grant D et al (2006) Survival after hepatic resection for colorectal metastases: a 10-year experience. Ann Surg Oncol 13:668–676
Zakaria S, Donohue JH, Que F G, et al (2007) Hepatic resection for colorectal metastases: value for risk scoring systems? Ann Surg 246:183–191
Kishi Y, Kopetz S, Chun YS et al (2009) Blood neutrophil-to-lymphocyte ratio predicts survival in patients with colorectal liver metastases treated with systemic chemotherapy. Ann Surg Oncol 16:614–622
Aloia TA, Vauthey JN, Loyer EM et al (2007) Solitary colorectal liver metastasis. Resection determines outcome. Arch Surg 141:460–467
Hamady ZZ, Malik HZ, Finch R et al (2006) Hepatic resection for colorectal metastasis: impact of tumour size. Ann Surg Oncol 13:1493–1439
Kokudo N, Imamura H, Sugawara Y et al (2004) Surgery for multiple hepatic colorectal metastases. J Hepatobiliary Pancreat Surg 11:84–91
Pawlik TM, Abdalla EK, Ellis LM et al (2006) Debunking dogma: surgery for four or more colorectal liver metastases is justified. J Gastrointest Surg 10:240–248
Tanaka K, Adam R, Shimada H et al (2003) Role of neoadjuvant chemotherapy in the treatment of multiple colorectal metastases to the liver. Br J Surg 90: 963–969
Smith MD McCall JL (2009) Systematic review of tumour number and outcome after radical treatment of colorectal liver metastases. Br J Surg 96:1101–1113
Kooby DA, Stockman J, Ben-Porat L et al (2003) Influence of transfusions on perioperative and long-term outcome in patients following hepatic resection for colorectal metastases. Ann Surg 237:860–869
Okano T, Ohwada S, Nakasone Y et al (2001) Blood transfusion causes deterioration in liver regeneration after partial hepatectomy in rats. J Surg Res 101:157–165
Kooby DA, Stockman J, Ben-Porat L et al (2003) Influence of transfusions on perioperative and long-term outcome in patients following hepatic resection for colorectal metastases. Ann Surg 237:860–870
Farid SG, Aldouri A, Morris-Stiff G et al (2010) Correlation between postoperative infective complications and long-term outcomes after hepatic resection for colorectal liver metastasis. Ann Surg 251:91–100
Reissfelder C, Rahbari NN, Koch M et al (2009) Validation of prognostic scoring systems for patients undergoing resection of colorectal cancer liver metastases. Ann Surg Oncol 16:3279–3288
Kattan MW, Gonen M, Jarnagin WR et al (2008) A nomogram for predicting disease-specific survival after hepatic resection for metastatic colorectal cancer. Ann Surg 247:282–287
Adam R, Pascal G, Castaing D et al (2004) Tumor progression while on chemotherapy. A contraindication to liver resection for multiple colorectal metastases? Ann Surg 240:1052–1064
Gruenberger B, Scheithauer W, Punzengruber R et al (2008) Importance of response to neoadjuvant chemotherapy in potentially curable colorectal cancer liver metastases. BMC Cancer 8:120
Saltz LB, Clarke S, Diaz-Rubio E et al (2008) Bevacizumab in combination with oxaliplatinbased chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol 26:2013–2019
Chun YS, Vauthey JN, Boonsirikamchai P et al. (2009) Association of computed tomography morphologic criteria with pathologic response and survival in patients treated with bevacizumab for colorectal liver metastases. JAMA 302:2338–2344
Rubbia-Brandt L, Giostra E, Brezault C et al (2007) Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery. Ann Oncol 18:299–304
Blazer DG III, Kishi Y, Maru DM et al (2008) Pathologic response to preoperative chemotherapy: a new outcome end point after resection of hepatic colorectal metastases. J Clin Oncol 26:5344–5351
DeOliveira ML, Pawlik TM, Gleisner AL et al (2007) Echogenic appearance of colorectal liver metastases on intraoperative ultrasonography is associated with survival after hepatic resection. J Gastrointest Surg 11:970–976
Canna K, McArdle PA, McMillan DC et al (2005) The relationship between tumor T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer. Br J Cancer 92:651–654
Okano K, Maeba T, Modoguchi A et al (2003) Lymphocytic infiltration surrounding liver metastases from colorectal cancer. J Surg Oncol 82:28–33
Neal CP, Garcea G, Doucas H et al (2006) Molecular prognostic markers in resectable colorectal liver metastases: a systematic review. Eur J Cancer 42:1728–1743
Domont J, Pawlik TM, Boige V et al (2005) Catalytic subunit of human telomerase reverse transcriptase is an independent predictor of survival in patients undergoing curative resection of hepatic colorectal metastases: a multicenter analysis. J Clin Oncol 23:3086–3093
Pantel K, von Knebel Doeberitz M (2000) Detection and clinical relevance of micrometastatic cancer cells. Curr Opin Oncol 12:95–101
Liotta LA, Stetler-Stevenson WG (1991) Tumor invasion and metastasis: an imbalance of positive and negative regulation. Cancer Res 51(suppl 18): 5054–5059
Koch M, Kienle P, Hinz U et al (2005) Detection of hematogenous tumor cell dissemination predicts tumor relapse in patients undergoing surgical resection of colorectal liver metastases. Ann Surg 241:199–205
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Ribero, D. (2011). Results of Surgery and Prognostic Factors. In: Capussotti, L. (eds) Surgical Treatment of Colorectal Liver Metastases. Updates in Surgery. Springer, Milano. https://doi.org/10.1007/978-88-470-1809-9_5
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DOI: https://doi.org/10.1007/978-88-470-1809-9_5
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