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Abstract

Over the past several decades, the 5-year survival rates after resection of colorectal liver metastases have almost doubled, from about 30% to about 60%. Among other factors, this improved survival has been attributed to better preoperative imaging techniques, which have improved patient selection. In patients being considered for surgical therapy of hepatic colorectal metastases, a high-quality crosssectional imaging study, either contrast-enhanced CT or MRI, should be performed to evaluate these metastases before surgery. MRI, however, is inferior to CT in the evaluation of extrahepatic disease but superior in patients after preoperative chemotherapy. PET/CT appears to improve patient selection and should be considered as part of the preoperative evaluation of resectability in high-risk patients.

Keywords

Positron Emission Tomography Liver Metastasis Colorectal Liver Metastasis Spiral Compute Tomography Extrahepatic Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Ong KO, Leen E (2007) Radiological staging of colorectal liver metastases. Surg Oncol 16:7–14CrossRefPubMedGoogle Scholar
  2. 2.
    Simmonds PC, Primrose JN, Colquitt JL et al (2006) Surgical resection of hepatic metastases from colorectal cancer: a systematic review of published studies. Br J Cancer 94:982–999CrossRefPubMedGoogle Scholar
  3. 3.
    Regge D, Cirillo S, Macera A et al (2009) Mangafodipir trisodium: review of its use as an injectable contrast medium for magnetic resonance imaging. Reports in Medical Imaging 2:55–68Google Scholar
  4. 4.
    Floriani I, Torri V, Rulli E et al (2010) Performance of imaging modalities in diagnosis of liver metastases from colorectal cancer: a Systematic review and meta-analysis. J Magn Reson Imaging 31:19–31CrossRefPubMedGoogle Scholar
  5. 5.
    Simmonds PC (2000) Palliative chemotherapy for advanced colorectal cancer: systematic review and meta-analysis. Colorectal Cancer Collaborative Group. British Medical Journal 321:531–535CrossRefPubMedGoogle Scholar
  6. 6.
    Larsen LPS, Rosenkilde M, Christensen H et al (2007) The value of contrast enhanced ultrasonography in detection of liver metastases from colorectal cancer: a prospective double-blinded study. Eur J Radiol 62:302–307CrossRefPubMedGoogle Scholar
  7. 7.
    Scott DJ, Guthrie JA, Arnold P et al (2001) Dual phase helical CT versus portal venous phase CT for the detection of colorectal liver metastases: correlation with intra-operative sonography, surgical and pathological findings. Clinical Radiol 56:235–242CrossRefGoogle Scholar
  8. 8.
    Bluemke DA, Paulson EK, Choti MA et al (2000) Detection of hepatic lesions in candidates for surgery: comparison of ferumoxides-enhanced MR imaging and dualphase helical CT. Am J Roentgenol 175:1653–1658Google Scholar
  9. 9.
    Schima W, Kulinna C, Langenberger H et al (2005) Liver metastases of colorectal cancer: US, CT or MR? Cancer Imaging. Spec No A:S149–56Google Scholar
  10. 10.
    Weg N, Scheer MR, Gabor MP (1998) Liver lesions: improved detection with dual-detectorarray CT and routine 2.5-mm thin collimation. Radiology 209:417–26PubMedGoogle Scholar
  11. 11.
    Kopka L, Grabbe E (1999) Biphasische Leberdiagnostik mit der Mehrzeilendetektor-Spiral-CT. Radiologe 39:971–978CrossRefPubMedGoogle Scholar
  12. 12.
    Kulinna C, Helmberger T, Kessler M et al (2001) Verbesserung der Diagnostik von Lebermetastasen mit der Multi-Detektor-CT. Radiologe 41:16–23CrossRefPubMedGoogle Scholar
  13. 13.
    Van Hoe L, Baert AL, Gryspeerdt S (1997) Dual-phase helical CTof the liver: value of an early-phase acquisition in the differential diagnosis of noncystic focal lesions. Am J Roentgenol 168:1185–1192Google Scholar
  14. 14.
    Padovani B, Lecesne R, Raffaelli C et al (1996) Tolerability and utility of mangafodipir trisodium injection (MnDPDP) at the dose of 5 μmol/kg body weight in detecting focal liver tumors: results of a phase III trial using an infusion technique. Eur J Radiol 23:205–211CrossRefPubMedGoogle Scholar
  15. 15.
    Gearhart SL, Frassica D, Rosen R et al (2006) Improved staging with pretreatment positron emission tomography/computed tomography in low rectal cancer. Ann Surg Oncol 13:397–404CrossRefPubMedGoogle Scholar
  16. 16.
    Kamel IR, Georgiades C, Fishman EK (2003) Incremental value of advanced image processing of multislice computed tomography data in the evaluation of hypervascular liver lesions. J Comp Assisted Tomography 27:652–656CrossRefGoogle Scholar
  17. 17.
    Sahani D, Mehta A, Blake M et al (2004) Preoperative hepatic vascular evaluation with CT and MR angiography: implications for surgery. Radiographics 24:1367–1380CrossRefPubMedGoogle Scholar
  18. 18.
    Yim PJ, Vora AV, Raghavan D et al (2006) Volumetric analysis of liver metastases in computed tomography with the fuzzy C-means algorithm. J Comp Assisted Tomography 30:212–220CrossRefGoogle Scholar
  19. 19.
    Zappa M, Dondero F, Sibert A et al (2009) Liver regeneration at day 7 after right hepatectomy: global and segmental volumetric analysis by using CT. Radiology 252:426–432PubMedGoogle Scholar
  20. 20.
    Freeny PC, Gardner JC, von Ingersleben G et al (1995) Hepatic helical CT: effect of reduction of iodine dose of intravenous contrast material on hepatic contrast enhancement. Radiology 197:89–93PubMedGoogle Scholar
  21. 21.
    Hale HL, Husband JE, Gossios K et al (1998) CT of calcified liver metastases in colorectal cancer. Clin Radiol 53:735–741CrossRefPubMedGoogle Scholar
  22. 22.
    Gandhi SN, Brown MB, Wong JG et al (2006) MR contrast agents for liver imaging: what, when, how. Radiographics 6:1621–1636CrossRefGoogle Scholar
  23. 23.
    Koh DM, Brown G, Riddell AM et al (2008) Detection of colorectal hepatic metastases using MnDPDP MR imaging and diffusion-weighted imaging (DWI) alone and in combination. Eur Radiol 18:903–910CrossRefPubMedGoogle Scholar
  24. 24.
    Scott DJ, Guthrie JA, Arnold P et al (2001) Dual phase helical CT versus portal venous phase CT for the detection of colorectal liver metastases: correlation with intra-operative sonography, surgical and pathological findings. Clin Radiol 56:235–242CrossRefPubMedGoogle Scholar
  25. 25.
    Albrecht T, Blomley MJ, Burns PN et al (2003) Improved detection of hepatic metastases with pulse-inversion US during the liver-specific phase of SHU 508A: multicenter study. Radiology 227:361–370CrossRefPubMedGoogle Scholar
  26. 26.
    Quaia E, D’Onofrio M, Palumbo A et al (2006) Comparison of contrast-enhanced ultrasonography versus baseline ultrasound and contrast-enhanced computed tomography in metastatic disease of the liver: diagnostic performance and confidence. Eur Radiol 16:1599–1609CrossRefPubMedGoogle Scholar
  27. 27.
    Larsen LPS, Rosenkilde M, Christensen H et al (2009) Can contrast-enhanced ultrasonography replace multidetector-computed tomography in the detection of liver metastases from colorectal cancer? Eur J Radiol 69:308–313CrossRefPubMedGoogle Scholar
  28. 28.
    Sharma S, Camci C, Jabbour N (2008) Management of hepatic metastasis from colorectal cancers: an update. J Hepatobiliary Pancreat Surg 15:570–580CrossRefPubMedGoogle Scholar
  29. 29.
    Federle MP, Chezmar JL, Rubin DL et al (2000) Safety and efficacy of mangafodipir trisodium (MnDPDP) injection for hepatic MRI in adults: results of the US multicenter phase III clinical trials. Efficacy of early imaging. J Magn Reson Imaging 12:689–701CrossRefPubMedGoogle Scholar
  30. 30.
    Bartolozzi C, Donati F, Cioni D et al (2004) Detection of colorectal liver metastases: a prospective multi center trial comparing unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT. Eur Radiol 14:14–20CrossRefPubMedGoogle Scholar
  31. 31.
    Kim KW, Kim AY, Kim TK et al (2004) Small (>2 cm) hepatic lesion in colorectal cancer patients: detection and characterization on mangafodipir trisodium-enhanced MRI. Am J Roentgenol 14:14–20Google Scholar
  32. 32.
    Regge D, Campanella D, Anselmetti GC et al (2006) Diagnostic accuracy of portal phase CT and MRI with Mangafodipir trisodium in detecting liver metastases from colorectal carcinoma. Clin Rad 61:338–347CrossRefGoogle Scholar
  33. 33.
    Lai CH, Yen TC, Chang TC (2007) Positron emission tomography imaging for gynecologic malignancy. Curr Opin Obstet Gynecol 19:37–41CrossRefPubMedGoogle Scholar
  34. 34.
    Rohren EM, Turkington TG, Coleman RE (2004) Clinical applications of PET in oncology. Radiology 231:305–332CrossRefPubMedGoogle Scholar
  35. 35.
    Wiering B, Krabbe PF, Jager GJ et al (2005) The impact of fluorine-18-deoxyglucose-positron emission tomography in the management of colorectal liver metastases. Cancer 104:2658–2670CrossRefPubMedGoogle Scholar
  36. 36.
    Fernandez FG, Drebin JA, Linehan DC et al (2004) Five-year survival after resection of hepatic metastases from colorectal cancer in patients screened by positron emission tomography with F-18 fluorodeoxyglucose (FDG-PET). Ann Surg 240:438–447CrossRefPubMedGoogle Scholar
  37. 37.
    Lubezky N, Metser U, Geva R et al (2007) The role and limitations of 18-fluoro-2-deoxy-Dglucose positron emission tomography (FDG-PET) scan and computerized tomography (CT) in restaging patients with hepatic colorectal metastases following neoadjuvant chemotherapy: comparison with operative and pathological findings. J Gastrointest Surg 11:472–478CrossRefPubMedGoogle Scholar
  38. 38.
    Akhurst T, Kates TJ, Mazumdar M et al (2005) Recent chemotherapy reduces the sensitivity of [18F]fluorodeoxyglucose positron emission tomography in the detection of colorectal metastases. J Clin Oncol 23:8713–8716CrossRefPubMedGoogle Scholar
  39. 39.
    Sahani DV, Kalva SP, Fischman AJ et al (2005) Detection of liver metastases from adenocarcinoma of the colon and pancreas. Comparison of MnDPDP liver MRI and whole body FDG PET. Am J Roengenol 185:239–246Google Scholar
  40. 40.
    Adie S, Yip C, Chu F, Morris DL (2009) Resection of liver metastases from colorectal cancer: does preoperative chemotherapy affect the accuracy of PET in preoperative planning? ANZ J Surg 79:358–361CrossRefPubMedGoogle Scholar
  41. 41.
    Abdalla EK, Barnett CC, Doherty D et al (2002) Extended hepatectomy in patients with hepatobiliary malignancies with and without preoperative portal vein embolization. Arch Surg 137:675–680CrossRefPubMedGoogle Scholar
  42. 42.
    Orlacchio A, Schillaci O, Fusco N et al (2009) Role of PET/CT in the detection of liver metastases from colorectal cancer. Radiol med 114:571–585CrossRefPubMedGoogle Scholar
  43. 43.
    Zacherl J, Scheuba C, Imhof M et al (2002) Current value of intraoperative sonography during surgery for hepatic neoplasms. World J Surg 26:550–554CrossRefPubMedGoogle Scholar
  44. 44.
    Tamandl D, Herberger B, Gruenberger B et al (2008) Adequate preoperative staging rarely leads to a change of intraoperative strategy in patients undergoing surgery for colorectal cancer liver metastases. Surgery 143:648–657CrossRefPubMedGoogle Scholar
  45. 45.
    Gallo T, Cirillo S, Macera A et al (2009) To compare the diagnostic accuracy of portal-phase CT and MRI with mangafodipir trisodium in detection colorectal carcinoma following neoadjuvant therapy. [oral presentation] — ESGAR, June 23–26, ValenciaGoogle Scholar
  46. 46.
    Koh DM, Scurr E, Collins DJ et al (2006) Colorectal hepatic metastases: quantitative measurements using single-shot echo planar diffusion-weighted MR imaging. Eur Radiol 16:1898–1905CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia 2011

Authors and Affiliations

  • Stefano Cirillo
    • 1
  1. 1.Radiology UnitMauriziano “Umberto I” HospitalTurinItaly

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