Skip to main content

Istopatologia dei tumori epiteliali maligni delle ghiandole salivari

  • Chapter
Tumori della testa e del collo
  • 1062 Accesses

Riassunto

Dati elaborati da Rarecare (www.rarecare.eu), il progetto europeo per la stima dell’incidenza dei tumori rari, indicano che l’incidenza annuale globale dei tumori maligni delle ghiandole salivari è di circa 2 casi/100.000 persone. Negli Stati Uniti, le neoplasie maligne delle ghiandole salivari costituiscono circa il 6% di tutti i tumori maligni del distretto testa e collo, e lo 0.3% di tutti i tumori maligni. Il 64–80% di tutti i tumori epiteliali primitivi delle ghiandole salivari si manifestano nelle ghiandole parotidi, il 7–11% nelle ghiandole sottomandibolari, meno dell’1% nelle ghiandole sottolinguali, e il 9–23% nelle ghiandole salivari minori. I tumori benigni rappresentano il 54–79%, mentre il 21–46% sono maligni. I tumori maligni comprendono il 15–32% dei tumori parotidei, il 41– 45% dei tumori sottomandibolari, il 70–90% dei tumori sottolinguali e circa il 50% dei tumori delle ghiandole salivari minori. L’80–90% dei tumori che originano dalle ghiandole salivari minori della lingua, del pavimento orale e delle aree retromolari sono maligni.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliografia

  1. Barnes L, Eveson JW, Reichart P, Sidransky D (Eds) (2005) World Health Organization Classification of Tumours. Pathology and Genetics of Head and NeckTumours. IARC, Lyon

    Google Scholar 

  2. Batsakis JG, Luna MA, El Naggar AK (1990) Histopathologic grading of salivary gland neoplasms: II. Acinic cell carcinomas. Ann Otol Rhinol Laryngol 99:929–933

    PubMed  CAS  Google Scholar 

  3. Ellis GL, Auclair PL (1996) Tumours of the salivary glands, n3rd ed. Armed Forces Institute of Pathology, Washington

    Google Scholar 

  4. Lewis JE, Olsen KD, Weiland LH (1991) Acinic cell carcinoma. Clinicopathologic review. Cancer 67:172–179

    Article  PubMed  CAS  Google Scholar 

  5. Seifert G (1992) Histopathology of malignant salivary gland tumours. Eur J Cancer B Oral Oncol 28B:49–56

    Article  PubMed  CAS  Google Scholar 

  6. Seifert G, Sobin LH (1991) Histological Typing of Salivary Gland Tumours. Springer-Verlag, Berlin

    Google Scholar 

  7. Michal M, Skalova A, Simpson RH et al (1997) Well-differendated acinic cell carcinoma of salivary glands associated with lymphoid stroma. Hum Pathol 28:595–600

    Article  PubMed  CAS  Google Scholar 

  8. Dardick I (1998) Mounting evidence against current histogenetic concepts for salivary gland tumorigenesis. Eur J Morphol 36 Suppl:257–261

    PubMed  Google Scholar 

  9. Zbaeren P, Lehmann W, Widgren S (1991) Acinic cell carcinoma of minor salivary gland origin. J Laryngol Otol 105:782–785

    Article  PubMed  CAS  Google Scholar 

  10. Guimaraes DS, Amaral AP, Prado LF, Nascimento AG (1989) Acinic cell carcinoma of salivary glands: 16 cases with clinicopathologic correlation. J Oral Pathol Med 18:396–399

    Article  PubMed  CAS  Google Scholar 

  11. Hoffman HT, Karneil LH, Robinson RA et al (1999). National Cancer Data Base report on cancer of the head and neck: acinic cell carcinoma. Head Neck 21:297–309

    Article  PubMed  CAS  Google Scholar 

  12. Lopes MA, Kowalski LP, da Cunha Santos G, Paes de Almeida O (1999) A clinicopathologic study of 196 intraoral minor salivary gland tumours. J Oral Pathol Med 28:264–267

    Article  PubMed  CAS  Google Scholar 

  13. Vargas PA, Gerhard R, Araujo Filho V, de Castro IV (2002) Salivary gland tumors in a Brazilian population: a retrospective study of 124 cases. Rev Hosp Clin Fac Med Sao Paulo 57:271–276

    PubMed  Google Scholar 

  14. Auclair PL, Goode RK, Ellis GL (1992) Mucoepidermoid carcinoma of intraoral salivary glands. Evaluation and application of grading criteria in 143 cases. Cancer 69:2021–2030

    Article  PubMed  CAS  Google Scholar 

  15. Brandwein MS, Ivanov K, Wallace DI et al (2001) Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol 25:835–845

    Article  PubMed  CAS  Google Scholar 

  16. Guzzo M, Andreola S, Sirizzotti G, Cantu G (2002) Mucoepidermoid carcinoma of the salivary glands: clinicopathologic review of 108 patients treated at the National Cancer Institute of Milan. Ann Surg Oncol 9:688–695

    Article  PubMed  Google Scholar 

  17. Monoo K, Sageshima M, Ito E et al (2003) Histopathological grading and clinical features of patients with mucoepidermoid carcinoma of the salivary glands. Nippon Jibiinkoka Gakkai Kaiho 106:192–198

    Article  PubMed  Google Scholar 

  18. Nascimento AG, Amaral AL, Prado La et al (1986) Adenoid cystic carcinoma of salivary glands. A study of 61 cases with clinicopathologic correlation. Cancer 57:312–319

    Article  PubMed  CAS  Google Scholar 

  19. Spiro RH, Huvos AG, Strong EW (1974) Adenoid cystic carcinoma of salivary origin. A clinicopathologic study of 242 cases. Am J Surg 128:512–520

    Article  PubMed  CAS  Google Scholar 

  20. Szanto PA, Luna MA, Tortoledo ME, White RA (1984) Histologic grading of adenoid cystic carcinoma of the salivary glands. Cancer 54:1062–1069

    Article  PubMed  CAS  Google Scholar 

  21. Spiro RH (1986) Salivary neoplasms: overview of a 35-year experience with 2.807 patients. Head Neck Surg 8:177–184

    Article  PubMed  CAS  Google Scholar 

  22. Waldron CA, el Mofty SK, Gnepp DR (1988) Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol 66:323–333

    Article  PubMed  CAS  Google Scholar 

  23. Castle JT, Thompson LD, Frommelt RA et al (1999) Polymorphous low grade adenocarcinoma: a clinic opathologic study of 164 cases. Cancer 86:207–219

    Article  PubMed  CAS  Google Scholar 

  24. Evans HL, Luna MA (2000) Polymorphous low-grade adenocarcinoma: a study of 40 cases with long-term followup and an evaluation of the importance of papillary areas. Am J Pathol 24:1319–1328

    Article  CAS  Google Scholar 

  25. Kemp BL, Batsakis JG, El Naggar AK et al (1995) Terminal duct adenocarcinomas of the parotid gland. J Laryngol Otol 109:466–468

    Article  PubMed  CAS  Google Scholar 

  26. Wenig BM, Harpaz N, DelBridge C (1989) Polymorphous low-grade adenocarcinoma of seromucous glands of the nasopharynx. A report of a case and a discussion of the morphologic and immunohistochemical features. Am J Clin Pathol 92:104–109

    PubMed  CAS  Google Scholar 

  27. Michal M, SkalovaA, Simpson RH et al (1999) Cribriform adenocarcinoma of the tongue: a hitherto unrecognized type of adenocarcinoma characteristically occurring in the tongue. Histopathology 35:495–501

    Article  PubMed  CAS  Google Scholar 

  28. Cho KJ, El Naggar AK, Ordonez NG et al (1995) Epithelial-myoepithelial carcinoma of salivary glands. A clinicopathologic, DNA flow cytometric, and immunohistochemical study of Ki-67 and HER-2/neu oncogene. Am J Clin Pathol 103:432–437

    PubMed  CAS  Google Scholar 

  29. Fonseca I, Soares J (1993) Epithelial-myoepithelial carcinoma of the salivary glands. A study of 22 cases. Virchows Arch A Pathol Anat Histopathol 422:389–396

    Article  PubMed  CAS  Google Scholar 

  30. Luna MA, Ordonez NG, Mackay B et al (1985) Salivary epithelial-myoepithelial carcinoma of intercalated ducts: a clinical, electron microscopic, and immunocytochemical study. Oral Surg Oral Med Oral Pathol 59:482–490

    Article  PubMed  CAS  Google Scholar 

  31. Pelosi G, Fraggetta F (2002) Epithelial-myoepithelial carcinomas of the bronchus. Am J Surg Pathol 26:951

    Article  Google Scholar 

  32. Fonseca I, Felix A, Soares J (2000) Dedifferentiation in salivary gland carcinomas. Am J Surg Pathol 24:469–471

    Article  PubMed  CAS  Google Scholar 

  33. Michal M, Skalova A, Simpson RH et al (1996) Clear cell malignant myoepithelioma of the salivary glands. Histopathology 28:309–315

    Article  PubMed  CAS  Google Scholar 

  34. Batsakis JG, El Naggar AK, Luna MA (1994) Hyalinizing clear cell carcinoma of salivary origin. Ann Otol Rhinol Laryngol 103:746–748

    PubMed  CAS  Google Scholar 

  35. Grenevicki LF, Barker BF, Fiorella RM, Mosby EL (2001) Clear cell carcinoma of the palate. Int J Oral Maxillofac Surg 30:452–454

    Article  PubMed  CAS  Google Scholar 

  36. Milchgrub S, Gnepp DR, Vuitch F et al (1994) Hyalinizing clear cell carcinoma of salivary gland. Am J Surg Pathol 18:74–82

    Article  PubMed  CAS  Google Scholar 

  37. Rinaldo A, McLaren KM, Boccato P, Maran AG (1999) Hyalinizing clear cell carcinoma of the oral cavity and of the parotid gland. ORL J Otorhinolaryngol Relat Spec 61:48–51

    Article  PubMed  CAS  Google Scholar 

  38. Simpson RH, Sarsfield PT, Clarke T, Babajews AV (1990). Clear cell carcinoma of minor salivary glands. Histopathology 17:433–438

    Article  PubMed  CAS  Google Scholar 

  39. Wang B, Brandwein M, Gordon R et al (2002) Primary salivary clear cell tumors — a diagnostic approach: a clinicopathologic and immunohistochemical study of 20 patients with clear cell carcinoma, clear cell myoepithelial carcinoma, and epithelial-myoepithelial carcinoma. Arch Pathol Lab Med 126:676–685

    PubMed  Google Scholar 

  40. Ellis GL, Wiscovitch JG (1990) Basal cell adenocarcinomas of the major salivary glands. Oral Surg Oral Med Oral Pathol 69:461–469

    Article  PubMed  CAS  Google Scholar 

  41. Muller S, Barnes L (1996) Basal cell adenocarcinoma of the salivary glands. Report of seven cases and review of the literature. Cancer 78:2471–2477

    Article  PubMed  CAS  Google Scholar 

  42. Murty GE, Welch AR, Soames JV (1990) Basal cell adenocarcinoma of the parotid gland. J Laryngol Otol 104:151

    Google Scholar 

  43. Baiocco R, Palma O, Locatelli G (1995) Squamous carcinoma of the epiglottis with sebaceous differentiation. Report of a case. Pathologica 87:531–533

    PubMed  CAS  Google Scholar 

  44. Diedhiou A, Cazals-Hatem D, Rondini E et al (2001) Sebaceous carcinoma of the submandibular gland: a case report. Ann Pathol 21:348–351

    PubMed  CAS  Google Scholar 

  45. Ellis GL, Auclair PL, Gnepp DR (1991) Surgical Pathology of the Salivary Glands. WB Saunders: Philadelphia

    Google Scholar 

  46. Gnepp DR (1983) Sebaceous neoplasms of salivary gland origin: a review. Pathol Annu 1:71–102

    Google Scholar 

  47. Gnepp DR, Brannon R (1984) Sebaceous neoplasms of salivary gland origin. Report of 21 cases. Cancer 53:2155–2170

    Article  PubMed  CAS  Google Scholar 

  48. Linhartova A (1974) Sebaceous glands in salivary gland tissue. Arch Pathol 98:320–324

    PubMed  CAS  Google Scholar 

  49. Danford M, Eveson JW, Hood TR (1992) Papillary cystadenocarcinoma of the sublingual gland presenting as a ranula. Br J Oral Maxillofac Surg 30:270–272

    Article  PubMed  CAS  Google Scholar 

  50. Foss RD, Ellis GL, Auclair PL (1996). Salivary gland cystadenocarcinomas. A clinicopathologic study of 57 cases. Am J Surg Pathol 20:1440–1447

    Article  PubMed  CAS  Google Scholar 

  51. Shteyer A, Fundoianu —Dayan D (1986) Papillary cystic adenocarcinoma of minor salivary glands. Int J Oral Maxillofac Surg 15:361–364

    Article  PubMed  CAS  Google Scholar 

  52. Brandwein MS, Jagirdar J, Paul J et al (1990) Salivary duct carcinoma (cribriform salivary carcinoma of excretory ducts). A clinicopathologic and immunohistochemical study of 12 cases. Cancer 65:2307–2314

    Article  PubMed  CAS  Google Scholar 

  53. Delgado R, Klimstra D, Albores-Saavedra J (1996) Low grade salivary duct carcinoma A distinctive variant with a low grade histology and a predominant intraductal growth pattern. Cancer 78:958–967

    Article  PubMed  CAS  Google Scholar 

  54. Gnepp DR (2001) Diagnostic Surgical Pathology of the Head and Neck. WB Saunders: Philadelphia

    Google Scholar 

  55. Tatemoto Y, Ohno A, Osaki T (1996) Low malignant intraductal carcinoma on the hard palate: a variant of salivary duct carcinoma? Eur J Cancer B Oral Oncol 32B:275–277

    Article  PubMed  CAS  Google Scholar 

  56. Krogdahl AS, Schou C (1997) Mucinous adenocarcinoma of the sublingual gland. J Oral Pathol Med 26:198–200

    Article  PubMed  CAS  Google Scholar 

  57. Notani K, Lizuka T, Yamazaki Y et al (2002) Mucinous adenocarcinoma of probable minor salivary gland origin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:738–740

    Article  PubMed  Google Scholar 

  58. Osaki T, Hirota J, Ohno A, Tatemoto Y (1990) Mucinous adenocarcinoma of the submandibular gland. Cancer 66:1796–1801

    Article  PubMed  CAS  Google Scholar 

  59. Tambouret RH, Yantiss RK, Kirby R, Eichhorn JH (1999) Mucinous adenocarcinoma of the parotid gland. Report of a case with fine needle aspiration findings and histologic correlation. Acta Cytol 43:842–846

    Article  PubMed  CAS  Google Scholar 

  60. Brandwein MS, Huvos AG (1991) Oncocytic tumors of major salivary glands. A study of 68 cases with follow-up of 44 patients. Am J Surg Pathol 15:514–528

    Article  PubMed  CAS  Google Scholar 

  61. Nakada M, Nishizaki K, Akagi H et al (1998) Oncocytic carcinoma of the submandibular gland: a case report and literature review. J Oral Pathol Med 27:225–228

    Article  PubMed  CAS  Google Scholar 

  62. Sugimoto T, Waltizono S, Uemura T et al (1993) Malignant oncocytoma of the parotid gland: a case report with an immunohistochemical and ultrastructural study. J Laryngol Otol 107:69–74

    PubMed  CAS  Google Scholar 

  63. Ito K, Tsukuda M, Kawabe R et al (2000) Benign and malignant oncocytoma of the salivary glands with an immunohistochemical evaluation of Ki-67. ORL J Otorhinolaryngol Relat Spec 62:338–341

    Article  PubMed  CAS  Google Scholar 

  64. Goode RK, Corio RL (1988) Oncocytic adenocarcinoma of salivary glands. Oral Surg Oral Med Oral Pathol 65:61–66

    Article  PubMed  CAS  Google Scholar 

  65. Gray SR, Cornog JL Jr, Seo IS (1976) Oncocytic neoplasms of salivary glands: a report of fifteen cases including two malignant oncocytomas. Cancer 38:1306–1317

    Article  PubMed  CAS  Google Scholar 

  66. Epivatianos A, Dimitrakopoulos J, Trigonidis G (1995) Intraoral salivary duct carcinoma: a clinicopathological study of four cases and review of the literature. Ann Dent 54:36–40

    PubMed  CAS  Google Scholar 

  67. Kumar RV, Kini L, Bhargava AK et al (1993) Salivary duct carcinoma J Surg Oncol 54:193–198

    Article  PubMed  CAS  Google Scholar 

  68. Pesce C, Colacino R, Buffa P (1986) Duct carcinoma of the minor salivary glands: a case report. J Laryngol Otol 100:611–613

    Article  PubMed  CAS  Google Scholar 

  69. Theaker JM (1988) Extramammary Paget’s disease of the oral mucosa with in situ carcinoma of minor salivary gland ducts. Am J Surg Pathol 12:890–895

    Article  PubMed  CAS  Google Scholar 

  70. Yoshimura Y, Tawara K, Yoshigi J, Nagaoka S (1995) Concomitant salivary duct carcinoma of a minor buccal salivary gland and papillary cystadenoma lymphomatosum of a cervical lymph node: report of a case and review of the literature. J Oral Maxillofac Surg 53:448–453

    Article  PubMed  CAS  Google Scholar 

  71. Zohar Y, Shem-Tov Y, Gal R (1988) Salivary duct carcinoma in major and minor salivary glands. A clinicopathological analysis of four cases. J Craniomaxillofac Surg 16:320–323

    Article  PubMed  CAS  Google Scholar 

  72. Barnes L, Rao U, Krause J et al (1994) Salivary duct carcinoma. Part I. A clinicopathologic evaluation and DNA image analysis of 13 cases with review of the liter at ure. Oral Surg Oral Med Oral Pathol 78:64–73

    Article  PubMed  CAS  Google Scholar 

  73. Matsuba HM, Mauney M, Simpson JR. Et al (1988) Adenocarcinomas of major and minor salivary gland origin: a histopathologic review of treatment failure patterns. Laryngoscope 98:784–788

    PubMed  CAS  Google Scholar 

  74. Nagao K, Matsuzaki O, Saiga H et al (1986) Histopathologic studies on adenocarcinoma of the parotid gland. Acta Pathol Jpn 36:337–347

    PubMed  CAS  Google Scholar 

  75. Spiro RH, Huvos AG, Strong EW (1982) Adenocarcinoma of salivary origin. Clinicopathologic study of 204 patients. Am J Surg 144:423–431

    Article  PubMed  CAS  Google Scholar 

  76. Simpson RH, Skalova A (1997) Metastatic carcinoma of the prostate presenting as parotid tumour. Histopathology 30:70–74

    Article  PubMed  CAS  Google Scholar 

  77. Tazawa K, KuriharaY, Kamoshida S et al (1999) Localization of prostata-specific antigen-like immunoreactivity in human salivary gland and salivary gland tumors. Pathol Int 49:500–505

    Article  PubMed  CAS  Google Scholar 

  78. Wahlberg P, Anderson H, Biorklund A. et al (2002) Carcinoma of the parotid and submandibular glands — a study of survival in 2465 patients. Oral Oncol 38:706–713

    Article  PubMed  Google Scholar 

  79. Savera AT, Sloman A, Huvos AG, Klimstra DS (2000) Myoepithelial carcinoma of the salivary glands: a clinicopathologic study of 25 patients. Am J Surg Pathol 24:761–774

    Article  PubMed  CAS  Google Scholar 

  80. Di Palma S, Guzzo M (1993) Malignant myoepithelioma of salivary glands: clinicopathological features of ten cases. Virchows A Pathol Anat Histopathol 423:389–396

    Article  CAS  Google Scholar 

  81. Hungermann D, Roeser K, Buerger H et al (2002) Relative paucity of gross genetic alterations in myoepitheliomas and myoepithelial carcinomas of salivary glands. J Pathol 198:487–194

    Article  PubMed  CAS  Google Scholar 

  82. Nagao T, Sugano I, Ishida Y et al (1998) Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases. Cancer 83:1292–1299

    Article  PubMed  CAS  Google Scholar 

  83. Gnepp DR (1993) Malignant mixed tumors of the salivary glands: a review. Pathol Annu 28 Pt 1:279–328

    Google Scholar 

  84. Furukawa M, Suzuki H, Matsuura K et al (2001) Carcinoma ex pleomorphic adenoma of the palatal minor salivary gland with extension into the nasopharynx. Auris Nasus Larynx 28:279–281

    Article  PubMed  CAS  Google Scholar 

  85. Klijanienko J, El Naggar AK, Servois V et al (1998) Mucoepidermoid carcinoma ex pleomorphic adenoma: nonspecific preoperative cytologic findings in six cases. Cancer 84:231–234

    Article  PubMed  CAS  Google Scholar 

  86. Lewis JE, Olsen KD, Sebo TJ (2001) Carcinoma ex pleomorphic adenoma: pathologic analysis of 73 cases. Hum Pathol 32:596–604

    Article  PubMed  CAS  Google Scholar 

  87. Felix A, Rosa-Santos J, Mendonca ME et al (2002) Intracapsular carcinoma ex pleomorphic adenoma. Report of a case with unusual metastatic behaviour. Oral Oncol 38:107–110

    Article  PubMed  CAS  Google Scholar 

  88. Bleiweiss 1J, Huvos AG, Lara J, Strong EW (1992) Carcinosarcoma of the submandibular salivary gland. Immunohistochemical findings. Cancer 69:2031–2035

    CAS  Google Scholar 

  89. Alvarez-Canas C, Rodilla IG (1996) True malignant mixed tumor (carcinosarcoma) of the parotid gland. Report of a case with immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 81:454–458

    Article  PubMed  CAS  Google Scholar 

  90. Gogas J, Markopoulos C, Karydakis V et al (1999) Carcinosarcoma of the submandibular salivary gland. Eur J Surg Oncol 25:333–335

    PubMed  CAS  Google Scholar 

  91. Gotte K, Riedel F, Coy JF et al (2000) Salivary gland carcinosarcorna: immunohistochemical, molecular genetic and electron microscopic findings. Oral Oncol 36:360–364

    Article  PubMed  CAS  Google Scholar 

  92. Harada H (2000) Histomorphological investigation regarding to malignant transformation of pleomorphic adenoma (so-called malignant mixed tumor) of the salivary gland origin: special reference to carcinosarcoma. Kurume Med J 47:307–323

    Article  PubMed  CAS  Google Scholar 

  93. Kim T, Yoon GS, Kim O, Gong G (1998) Fine needle aspiration diagnosis of malignant mixed tumor (carcinosarcoma) arising in pleomorphic adenoma of the salivary gland. A case report. Acta Cytol 42:1027–1031

    Article  PubMed  CAS  Google Scholar 

  94. Sironi M, Isimbaldi G, Claren R et al (2000) Carcinosarcoma of the parotid gland: cytological, clinicopathological and immunohistochemical study of a case. Pathol Res Pract 196:511–517

    Article  PubMed  CAS  Google Scholar 

  95. Stephen J, Batsakis JG, Luna MA et al (1986) True malignant mixed tumors (carcinosarcoma) of salivary glands. Oral Surg Oral Med Oral Pathol 61:597–602

    Article  PubMed  CAS  Google Scholar 

  96. Kwon MY, Gu M (2001) True malignant mixed tumor (carcinosarcoma) of parotid gland with unusual mesenchymal component: a case report and review of the literature. Arch Pathol Lab Med 125:812–815

    PubMed  CAS  Google Scholar 

  97. Ernster JA, Franquemont DW, Sweeney JP (2000) Initial report of a case of carcinosarcoma of the supraglottis. Ear Nose Throat J 79:384–387

    PubMed  CAS  Google Scholar 

  98. Chen I, Tu H (2000) Pleomorphic adenoma of the parotid gland metastasizing to the cervical lymph node. Otolaryngol Head Neck Surg 122:455–457

    Article  PubMed  CAS  Google Scholar 

  99. Wenig BM, Hitchcock CL, Ellis GL, Gnepp DR (1992) Metastasizing mixed tumor of salivary glands. A clinicopathologic and flow cytometric analysis. Am J Surg Pathol 16:845–858.

    Article  PubMed  CAS  Google Scholar 

  100. Shemen LJ, Huvos AG, Spiro RH (1987) Squamous cell carcinoma of salivary gland origin. Head Neck Surg 9:235–240

    Article  PubMed  CAS  Google Scholar 

  101. Flynn MB, Maguire S, Martinez S, Tesmer T (1999) Primary squamous cell carcinoma of the parotid gland: the importance of correct histological diagnosis. Ann Surg Oncol 6:768–770

    Article  PubMed  CAS  Google Scholar 

  102. Gaughan RK, Olsen KD, Lewis JE (1992) Primary squamous cell carcinoma of the parotid gland. Arch Otolaryngol Head Neck Surg 118:798–801

    PubMed  CAS  Google Scholar 

  103. Lee S, Kim GE, Park CS et al (2001) Primary squamous cell carcinoma of the parotid gland. Am J Otolaryngol 22:400–406

    Article  PubMed  CAS  Google Scholar 

  104. Gnepp DR, Wick MR (1990) Small cell carcinoma of the major salivary glands. An immunohistochemical study. Cancer 66:185–192

    Article  PubMed  CAS  Google Scholar 

  105. Nagao T, Gaffey TA, Olsen KD et al (2004) Small cell carcinoma of the major salivary glands: clinicopathologic study with emphasis on cytokeratin 20 immunoreactivity and clinical outcome. Am J Surg Pathol 28:762–770

    Article  PubMed  Google Scholar 

  106. Gnepp DR, Corio RL, Brannon RB (1986) Small cell carcinoma of the major salivary glands. Cancer 58:705–714

    Article  PubMed  CAS  Google Scholar 

  107. Pierce ST, Cibull ML, Metcalfe MS, Sloan D (1994) Bone marrow metastases from small cell carcinoma of the head and neck. Head Neck 16:266–271

    Article  PubMed  CAS  Google Scholar 

  108. Hui KK, Luna MA, Batsakis JG et al (1990) Undifferentiated carcinomas of the major salivary glands. Oral Surg Oral Med Oral Pathol 69:76–83

    Article  PubMed  CAS  Google Scholar 

  109. Larsson LG, Donner LR (1999) Large cell neuroendocrine carcinoma of the parotid gland: fine needle aspiration, and light microscopic and ultrastructural study. Acta Cytol 43:534–536

    PubMed  CAS  Google Scholar 

  110. Moore JG, Bocklage T (1998) Fine-needle aspiration biopsy of large-cell undifferentiated carcinoma of the salivary glands: presentation of two cases, literature review, and differential cy todiagnosis of high-grade salivary gland malignancies. Diagn Cytopathol 19:44–50

    Article  PubMed  CAS  Google Scholar 

  111. Nagao K, Matsuzaki O, Saiga H et al (1982) Histopathologic studies of undifferentiated carcinoma of the parotid gland. Cancer 50:1572–1579

    Article  PubMed  CAS  Google Scholar 

  112. Nagao T, Sugano I, Ishida Y et al (2000) Primary largecell neuroendocrine carcinoma of the parotid gland: immunohistochemical and molecular analysis of two cases. Mod Pathol 13:554–561

    Article  PubMed  CAS  Google Scholar 

  113. Yaku Y, Kanda T, Yoshihara T et al (1983) Undifferenntiated carcinoma of the parotid gland. Case report with electron microscopic findings. Virchows Arch A Pathol Anat Histopathol 401:89–97

    Article  PubMed  CAS  Google Scholar 

  114. Albeck H, Nielsen NH, Hansen HE et al (1992) Epidemiology of nasopharyngeal and salivary gland carcinoma in Greenland. Arctic Med Res 51:189–195

    PubMed  CAS  Google Scholar 

  115. Borg MF, Benjamin CS, Morton RP, Llewellyn HR (1993) Malignant lymphoepithelial lesion of the salivary gland: a case report and review of the literature. Australas Radiol 37:288–291

    Article  PubMed  CAS  Google Scholar 

  116. Hamilton-Dutoit SJ, Therkildsen MH, Nielsen NH et al (1991) Undifferentiated carcinoma of the salivary gland in Greenlandic Eskimos: demonstration of Epstein-Barr virus DNA by in situ nucleic acid hybridization. Hum Pathol 22:811–815

    Article  PubMed  CAS  Google Scholar 

  117. Leung SY, Chung LP, Yuen ST et al (1995) Lymphoepithelial carcinoma of the salivary gland: in situ detection of Epstein-Barr virus. J Clin Pathol 48:1022–1027

    Article  PubMed  CAS  Google Scholar 

  118. Nagao T, Ishida Y, Sugano I et al (1996) Epstein-Barr virus-associated undifferentiated carcinoma with lymphoid stroma of the salivary gland in Japanese patients. Comparison with benign lymphoepithelial lesion. Cancer 78:695–703

    Article  PubMed  CAS  Google Scholar 

  119. Saw D, Lau WH, Ho JH et al (1986) Malignant lymphoepithelial lesion of the salivary gland. Hum Pathol 17:914–923

    Article  PubMed  CAS  Google Scholar 

  120. Sheen TS, Tsai CC, Ko JY et al (1997) Undifferentiated carcinoma of the major salivary glands. Cancer 80:357–363

    Article  PubMed  CAS  Google Scholar 

  121. Merrick Y, Albeck H, Nielsen NH, Hansen HS (1986) Familial clustering of salivary gland carcinoma in Greenland. Cancer 57:2097–2102

    Article  PubMed  CAS  Google Scholar 

  122. Albeck H, Bentzen J, Ockelmann HH et al (1993) Familial clusters of nasopharyngeal carcinoma and salivary gland carcinomas in Greenland natives. Cancer 72:196–200

    Article  PubMed  CAS  Google Scholar 

  123. Huang DP, Ng HK, Ho YH, Chan KM (1988) Epstein-Barr virus (EBV)-associated undifferentiared carcinoma of the parotid gland. Histopathology 13:509–517

    Article  PubMed  CAS  Google Scholar 

  124. Kuo T, Hsueh C (1997) Lymphoepithelioma-like salivary gland carcinoma in Taiwan: a clinicopathological study of nine cases demonstrating a strong association with Epstein-Barr virus. Histopathology 31:75–82

    Article  PubMed  CAS  Google Scholar 

  125. Lanier AP, Clift SR, Bornkamm G et al (1991) Epstein-Barr virus and malignant lymphoepithelial lesions of the salivary gland. Arctic Med Res 50:55–61

    PubMed  CAS  Google Scholar 

  126. Tsai CC, Chen CL, Hsu HC (1996) Expression of Epstein-Barr virus in carcinomas of salivary glands: a strong association with lymphoepithelioma-like carcinoma. Hum Pathol 27:258–262

    Article  PubMed  CAS  Google Scholar 

  127. Chan JK, Yip TT, Tsang WY et al (1994) Specific association of Epstein-Barr virus with lymphoepithelial carcinoma among tumors and tumorlike lesions of the salivary gland. Arch Pathol Lab Med 118:994–997

    PubMed  CAS  Google Scholar 

  128. Saw D, Ho JH, Lau WH, Chan J (1986) Parotid swelling as the first manifestation of nasopharyngeal carcinoma: a report of two cases. Eur J Surg Oncol 12:71–75

    PubMed  CAS  Google Scholar 

  129. Taylor GP (1988) Congenital epithelial tumor of the parotidsialoblastoma. Pediatr Pathol 8:447–452

    Article  PubMed  CAS  Google Scholar 

  130. Brandwein M, AI, Naeif NS, Manwani D et al (1999) Sialoblastoma:clinicopathological/immunohistochemical study. Am J Surg Pathol 23:342–348

    Article  PubMed  CAS  Google Scholar 

  131. Luna MA (1999) Sialoblastoma and epithelial tumors in children: their morphologic spectrum and distribution by age. Adv Anat Pathol 6:287–292

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Italia

About this chapter

Cite this chapter

Quattrone, P. (2011). Istopatologia dei tumori epiteliali maligni delle ghiandole salivari. In: Tumori della testa e del collo. Springer, Milano. https://doi.org/10.1007/978-88-470-1806-8_6

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-1806-8_6

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1805-1

  • Online ISBN: 978-88-470-1806-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics