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Tumori nell’anziano

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Tumori della testa e del collo

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La maggior parte dei tumori testa e collo si sviluppa durante il quinto e sesto decennio di vita [1], ma il 24% colpisce le persone di 70 e più anni [1]. Alcune caratteristiche cliniche differenziano il tumore testa collo delle persone di 70 e più anni da quello dei più giovani. La percentuale di donne affette da cancro testa e collo aumenta con l’età, un fatto che si può spiegare in parte con la maggiore aspettativa di vita media nelle donne. Anche la percentuale di pazienti con i più comuni fattori di rischio — fumo e alcol — diminuisce con l’età, al punto che ci si è chiesto se l’età non sia un fattore di rischio per queste neoplasie.

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Bibliografia

  1. Syrigos KN, Karakhalios D, Karapanagiotou EM et al (2009) Head and Neck Cancer in the Elderly: an Overview on the Treatment modalities. Cancer Treat Rev 32:237–245

    Article  Google Scholar 

  2. Walter LC, Covinsky KE (2001) Cancer screening in elderly patients: a framework for individualized decision making. JAMA 285:2750–2756

    Article  PubMed  CAS  Google Scholar 

  3. Walston J, Hadley EC, Ferrucci L et al (2001) Research Agenda for frailty in Older Adults. J Am Ger Soc 54:991–1001

    Article  Google Scholar 

  4. Gruenewald TL, Seeman TE, Karlamangla AS et al (2009) Allostatic load and frailty in older adults. J Am Geriatr Soc 57:1525–1531

    Article  PubMed  Google Scholar 

  5. Ferrucci L, Corsi A, Lauretani F et al (2005) The origin of Age-related pro-inflammatory state. Blood 105:2294–2299

    Article  PubMed  CAS  Google Scholar 

  6. Cohen HJ, Harris T, Pieper CF (2003) Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly. Am J Med 114:180–187

    Article  PubMed  Google Scholar 

  7. Leng SX, Xue QL, Tian J et al (2007) Inflammation and frailty in Older Women. J Am Geriatr Soc. 55:864–871

    Article  PubMed  Google Scholar 

  8. Gurven M, Kaplan H, Winking J et al (2008) Aging and inflammation in two epidemiological worlds. J Gerontol A Biol Sci Med Sci 63:196–201

    Article  PubMed  Google Scholar 

  9. Pierce BL, Ballard-Barbash R, Bernstein L et al (2009) Elevated Biomarkers of Inflammation Are Associated With Reduced Survival Among Breast Cancer Patients JCO 27:3437–3444

    CAS  Google Scholar 

  10. Balducci L (2009) Pharmacology of antineoplastic medications in older cancer patients. Oncology 23:78–85

    PubMed  Google Scholar 

  11. de Jonge HJ, de Bont ES, Valk PJ et al (2009) AML at older age: age-related gene expression profiles reveal a paradoxical down-regulation of pl6INK4A mRNA with prognostic significance. Blood 114:2869–2877

    Article  PubMed  Google Scholar 

  12. Kiepin HD, Balducci L (2009) Acute myeloid Leukemia in Older Adults. Oncologist 14:222–232

    Article  Google Scholar 

  13. Molina JR, Yang P, Cassivi SD et al (2008) Non small cell lung cancer: epidemiology, risk factors, treatment and surivorship. Mayo Clin Proc 83:584–594

    Article  PubMed  Google Scholar 

  14. Ershler WB, Stewart JA, Hacker MP et al (1984) B16 murine melanoma and aging: slower growth and longer survival in old mice. J Natl Cancer Inst 72:161–164

    PubMed  CAS  Google Scholar 

  15. Ershler WB (1986) Why tumors grow more slowly in Older People. J Natl Cancer Inst 77:837–839

    PubMed  CAS  Google Scholar 

  16. Morley JE (2003) Hormones and the aging process. J Am Ger Soc 51:333–337

    Article  Google Scholar 

  17. Campisi J, d’ Adda di Fagnana F (2007) Cellular senescence: when bad things happen to good cells. Nature Rev 8:729–740

    Article  CAS  Google Scholar 

  18. Carey EC, Covinsky KE, Lui LY et al (2008) Prediction of mortality in community-living frail elderly people with long-term care needs. J Ai Geriatr Soc 56:68–75

    Article  Google Scholar 

  19. Lee SJ, Lindquist K, Segal MR et al (2006) Development and validation of a prognostic index for 4-year mortality in older adults. JAMA 295:801–808

    Article  PubMed  CAS  Google Scholar 

  20. Song X, MacKnight C, Latta R et al (2007) Frailty and survival of rural and urban seniors: results from the Canadian Study of Health and Aging Aging Clin Exp Res 19:145–153

    Google Scholar 

  21. Extermann M, Chen H, Cantor AB et al (2002) Predictors of tolerance of chemotherapy in older patients. Eur J Cancer 38:1466–1473

    Article  PubMed  CAS  Google Scholar 

  22. Extermann M, Boler I, Reich G et al (2010) The Chemotherapy Risk Assessment Scale for High Age Patients (CRASH) score: design and validation. ASCO proceeding 2010. J Clin Oncol 28:15S, page 636s

    Google Scholar 

  23. Shayne M, Balducci L (2011) Hematopoietic Growth Factors in older cancer patients. Cancer Treat res 157:383–402

    Article  PubMed  CAS  Google Scholar 

  24. Schmader KE, Hanlon JT, Pieper CF et al (2004) Effects of Geriatric Evaluation and Management on Adverse Drug Reactions and Suboptimal Prescribing in Frail Elderly. Am J Med 116:394–401

    Article  PubMed  Google Scholar 

  25. Jyrkkä J, Enlund H, Korhonen MJ et al (2009); Pattern of drug use and factors associated with polypharmacy and excessive polypharmacy in elderly persons: results of the Kuopio 75+ study: across sectional analysis. Drugs Aging 26:493–503

    Article  PubMed  Google Scholar 

  26. Extermann M, Popa MA, Druta M et al (2009) Drug interactions assessed with Drug Interaction Facts are associated with increased risk of chemo toxicity in older cancer patients receiving chemotherapy. The 100th Annual Meeting of the American Association for Cancer Research, Denver, CO. Abstract 5450

    Google Scholar 

  27. Gallagher P, Ryan C, Byrne S et al (2008) STOPP (Screening Tool of Older Person’s prescriptions) and START (Screening Tool to Alert Doctors to Right Treatment). Int J Clin Pharmacol Therap 45:72–83

    Google Scholar 

  28. Dominguez LT (2009) Medicine and the Arts. L’incendio di Borgo. Commentary. Acad med 84:1260–1261

    Google Scholar 

  29. Piccirillo J, Feinsein AR (1996) Clinical Symptoms and Comorbidity: Significance for the Prognostic Classification of Cancer. Cancer 11:834–842

    Article  Google Scholar 

  30. Sanabria A, Lopes Carvalho A, Vartanian JG et al (2007) Comorbidity is a Prognostic Factor in Elderly Patients with Head and Neck Cancer. Ann Surg Oncol 14:1449–1457

    Article  PubMed  Google Scholar 

  31. Meyerhardt JA, Tepper JE, Niedzwiecki D et al (2004) Impact of body mass index on outcomes and treatment-related toxicity in patients with stage II and III rectal cancer: findings from Intergroup Trial 0114. J Clin Oncol 22:648–657

    Article  PubMed  Google Scholar 

  32. Read WL, Tierney RM, Page NC et al (2004) Differential Prognostic Impact of Comorbidity. J Clin Oncol 22:3099–3103

    Article  PubMed  Google Scholar 

  33. Picicrillo JF, Spitznagel EL, Vermani N et al (2004) Comparison of Comorbidity Indices in patients wiith Head and Neck cancer. Medical Care 42:482–486

    Article  Google Scholar 

  34. Marx GM, Blake GM, Galani E et al (2004) Evaluation of the Cockroft-Gault, Jelliffe and Wright formulas in estimating renal function in elderly cancer patients. Ann Oncol 15:291–295

    Article  PubMed  CAS  Google Scholar 

  35. Schrijvers D, Highley M, DeBruyn E et al (1999) Role of red blood cells in pharmacokinetics of chemo therapeutic agents. Anticancer Drugs 10:147–153

    Article  PubMed  CAS  Google Scholar 

  36. Bohlius J, Schmidlin K, Brillant C et al (2009) Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials. Lancet 373:1532–1542

    Article  PubMed  CAS  Google Scholar 

  37. Bennett CL, Silver SM, Djulbegovic B et al (2008) Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia JAMA 299:914–924 Review

    Article  PubMed  CAS  Google Scholar 

  38. Aapro M, Scherhag A, Burger HU (2008) Effect of treatment with epoetin-beta on survival, tumour progression and thromboembolic events in patients with cancer: aniupdated meta-analysis of 12 randomised controlled studies including 2301 patients. Br J Cancer 99:14–22

    Article  PubMed  CAS  Google Scholar 

  39. Ferrucci L, Balducci L (2008) Anemia in the older cancer patient: the role of inflammation and cancer. Sem Hematol 45:242–249

    Article  Google Scholar 

  40. Sonis ST (2007) Pathobiology of oral mucositis: novel insights and opportunities. J Support Oncol 5:3–11

    PubMed  CAS  Google Scholar 

  41. Worthington HV, Clarckson, Eden OB (2007) Pathobiology of oral mucositis: novel insights and opportunities. J Support Oncol 9:12–19

    Google Scholar 

  42. Rosen LS, Abdi E, Davis ID et al (2006) Palifermin reduces the incidence of oral mucositis in patients with metastatic colorectal cancer treated with fluorouracil-based chemotherapy. J Clin Oncol 24:5194–5200

    Article  PubMed  CAS  Google Scholar 

  43. Dodd MJ, Miaskowski C, Greenspan D et al (2003) Radiation-induced mucositis: a randomized clinical trial of micronized sucralfate versus salt & soda mouthwashes. Cancer Invest 21:21–33

    Article  PubMed  CAS  Google Scholar 

  44. Hoffmann W (2009) Trefoil Factor Family and chemochine receptors: a promising relationship. J Med Chem 52:6505–6510

    Article  PubMed  CAS  Google Scholar 

  45. Kuderer NM, Dale DC, Crawford J et al (2007) Impact of primary prophylaxis with granulocyte colony-stimulating factor on febrile neutropenia and mortality in adult cancer patients receiving chemotherapy: a systematic review. J Clin Oncol 25:3158–3167

    Article  PubMed  CAS  Google Scholar 

  46. Smith TJ, Katcheressian J, Lyman GH et al (2006) 2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline. J Clin Oncol 24:3187–3205

    Article  PubMed  CAS  Google Scholar 

  47. Crawford J, Armitage J, Balducci L et al (2009) National Comprehensive Cancer Network.: Myeloid Growth Factors J Natl Compr Canc Netw 7:64–83

    PubMed  CAS  Google Scholar 

  48. Walker M, Ni O (2007) Neuroprotection during chemotherapy: a systematic review. Am J Clin Oncol 30:82–92

    Article  PubMed  Google Scholar 

  49. Schaapveld M, Visser O, Lowman MJ et al (2008) Risk of new primary nonbreast cancers after breast cancer treatment: a Dutch population-based study. J Clin Oncol 26:1239–1246

    Article  PubMed  Google Scholar 

  50. Muss HB, Berry DA, Cirrincione C et al (2007) Toxicity of older and younger patients treated with adjuvant chemotherapy for node-positive breast cancer: the Cancer and Leukemia Group B Experience. J Clin Oncol 25:3699–3704

    Article  PubMed  CAS  Google Scholar 

  51. Patt DA, Duan Z, Fang S et al (2007) Acute myeloid leukemia after adjuvant breast cancer therapy in older women: understanding risk. J Clin Oncol 25:3871–3876

    Article  PubMed  Google Scholar 

  52. Hershman D, Neugut AI, Jacobson JS et al (2007) Acute myeloid leukemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy. J Natl Cancer Inst 99:196–205

    Article  PubMed  CAS  Google Scholar 

  53. Hershman DL, McBride RB, Eisenberger A et al (2008) Doxorubicin, cardiac risk factors, and cardiac toxicity in elderly patients with diffuse B-cell non-Hodgkin’s lymphoma. J Clin Oncol 26:3129–3165

    Google Scholar 

  54. Finder MC, Duan Z, Goodwin JS et al (2007) Congestive heart failure in older women treated with adjuvant anthracycline chemotherapy for breast cancer. J Clin Oncol 25:3808–3815

    Article  Google Scholar 

  55. Heck JE, Albert SM, Franco R, Gorin SS (2008) Patterns of dementia diagnosis in surveillance, epidemiology, and end results breast cancer survivors who use chemotherapy. J Am Geriatr Soc 56:1687–1692

    Article  PubMed  Google Scholar 

  56. Baxter NN, Durham SB, Phillips KA et al (2009) Risk of dementia in older breast cancer survivors: a populationbased cohort study of the association with adjuvant chemotherapy. J Am Geriatr Soc 57:403–411

    Article  PubMed  Google Scholar 

  57. Thein M, Ershler WB, Artz AS et al (2009) Diminished quality of life and physical function in community-dwelling elderly with anemia. Medicine (Baltimore) 88:107–114

    Article  Google Scholar 

  58. Luciani A, Jacobsen P, Extermann M et al (2008) Fatigue and functional dependence iniOlder Cancer Patients. Am J Clin Oncol 31:424–430

    Article  PubMed  Google Scholar 

  59. Balducci L (2010) Bone complications of cancer treatment in the elderly (Willingstone Park) 24:741–747

    Google Scholar 

  60. Balducci L, Colloca G, Cesari M, Gambassi G (2010) Assessment and treatment of elderly patients with cancer. Surg Oncol 19:117–123

    Article  PubMed  Google Scholar 

  61. Covinsky KE, Lindquist K, Dunlop DD et al (2009) Pain, functional limitations, and aging. J Am Geriatr Soc 57:1556–1561

    Article  PubMed  Google Scholar 

  62. Derks W, De Jr L, Hordijk DJ et al (2003) Elderly patients with Head and Neck Cancer: Short term effects of surgical treatment on quality of life. Clin Otolaryngol Allied Sci 28:399–405

    Article  PubMed  CAS  Google Scholar 

  63. Fu KK, Pajak TF, Trotti A et al (2000) A Radiation Therapy Oncology Group phase III randomized study to compare hyperfractionation and two variation of accelerated fractionation to standard fractionation radiotherapy for Head and Neck squamous cell carcinoma: first report of RTOG 9003. Int J Radiat Oncol Biol Phys 48:7–16

    Article  PubMed  CAS  Google Scholar 

  64. Bourhis J, Overgaard J, Audry H et al (2006) Hyperfractionated or accelerated radiotherapy in Head and Neck Cancer: a meta-analysis. Lancet 368:843–854

    Article  PubMed  Google Scholar 

  65. Oguchi M, Ikeda H, Watanabe T et al (1998) Experiences of 23 patients > or = 90 years of age treated with Radiation Therapy. Int J Rad Oncol Biol Phys 41:407–413

    Article  CAS  Google Scholar 

  66. Argiris A, Li Y, Murphy BA et al (2004) Outcome of Elderly Patients with Recurrent or Metastatic Head and Neck Cancer Treated with Cisplatm-Based Chemotherapy. J Clin Oncol 22:262–268

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. College of Medicine, Division of Geriatric Oncology, Moffitt Cancer Center, University of South Florida, Tampa, FL, USA

    Lodovico Balducci

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  1. Lodovico Balducci
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Balducci, L. (2011). Tumori nell’anziano. In: Tumori della testa e del collo. Springer, Milano. https://doi.org/10.1007/978-88-470-1806-8_21

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  • DOI: https://doi.org/10.1007/978-88-470-1806-8_21

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