Cryoglobulinemia and Chronic HCV Infection: An Evolving Story

  • Jürg A. Schifferli
  • Marten Trendelenburg


Cryoglobulinemia was identified and named many years ago by clinicians who related the in vitro precipitation of globulins from serum incubated in the cold with diseases. One major point was that there was no evidence for a known disease in many patients with “mixed” cryoglobulins. Thus, the terminology “mixed essential cryoglobulinemia” became accepted. The discovery of HCV as the causative agent of mixed essential cryoglobulinemia allowed not only the introduction of a new nomenclature (largely removing the designation “essential”), but studies of the relationship between this viral disease and the emergence of pathological clones of B cells.


Rheumatoid Factor Renal Tubular Acidosis Mixed Cryoglobulinemia Essential Mixed Cryoglobulinemia Mixed Cryoglobulins 
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Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  1. 1.Division of Internal Medicine, Department of MedicineUniversity Hospital BaselBaselSwitzerland
  2. 2.Clinic for Internal Medicine and Laboratory for Clinical ImmunologyUniversity Hospital BaselBaselSwitzerland

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