HCV-Associated Membranoproliferative Glomerulonephritis

  • Christos P. Argyropoulos
  • Sheldon Bastacky
  • John Prentiss Johnson


Hepatitis C virus (HCV) is a blood-borne and sexually transmitted single-stranded RNA flavivirus that causes a broad spectrum of liver disease, ranging from acute to chronic hepatitis, cirrhosis, and hepatocellular carcinoma. The worldwide prevalence of HCV positivity is highly variable. Hepatitis C infection is associated with a wide variety of renal diseases but the most common pattern of renal injury is Membranoproliferative glomerulonephritis (>50% of cases). This chapter reviews the epidemiology, pathogenesis, clinical and laboratory manifestations, pathology, and differential diagnosis of HCV-associated cryoglobulinemic. Therapeutic approaches to the management of patients with nephritic, nephritic, and vasculitic manifestations are also briefly considered.


Glomerular Basement Membrane Mixed Cryoglobulinemia Membranoproliferative Glomerulonephritis Glomerular Capillary Wall Mesangial Matrix Expansion 
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Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Christos P. Argyropoulos
    • 1
  • Sheldon Bastacky
    • 2
  • John Prentiss Johnson
    • 1
  1. 1.Renal and Electrolyte Division, Department of Internal MedicineUniversity of PittsburghPittsburghUSA
  2. 2.Department of PathologyUniversity of PittsburghPittsburghUSA

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