Biotechnological Approaches to Hemostasis and Molecular Mechanisms of Wound Healing

  • Anna Grimaldi
  • Francesco Rosso
  • Alfonso Barbarisi
Part of the Updates in Surgery book series (UPDATESSURG, volume 0)


Wounds today remain a difficult clinical problem due to early or late complications that are a frequent cause of mortality. To try to resolve this problem, many studies have focused on understanding physiologic healing and wound care, with particular emphasis on new therapeutic approaches and the continued development of biotechnology for the management of acute and long term injuries. Normal wound healing is a dynamic and complex process involving a series of coordinated events, including bleeding, coagulation, initiation of an acute inflammatory response to the initial injury, regeneration, migration and proliferation of connective tissue and parenchyma cells, as well as synthesis of extracellular matrix proteins, remodeling of new parenchyma and connective tissue and collagen deposition. Lastly, increasing wound strength takes place in an ordered manner and culminates in the repair of severed tissues [1.


Fibrin Sealant Biphasic Calcium Phosphate Difficult Clinical Problem Macroporous Biphasic Calcium Phosphate Blood Salvage System 


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Copyright information

© Springer-Verlag Italia 2011

Authors and Affiliations

  • Anna Grimaldi
    • 1
  • Francesco Rosso
    • 1
  • Alfonso Barbarisi
    • 1
  1. 1.Department of Anesthesiological, Surgical and Emergency SciencesSecond University of NaplesNaplesItaly

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