Abstract
The idea to use “genes” as “drugs” for human therapy was originally conceived in the United States around the 1970s. It was the logical consequence of at least two major advancements that were occurring in those years, namely the exponentially growing knowledge of human gene function and the impact of their mutations, and the development of progressively more effective technologies for the delivery of DNA into mammalian cells.
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Further Reading
Couzin-Frankel J (2009) Genetics. The promise of a cure: 20 years and counting. Science 324:1504–1507
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Zaldumbide A, Hoeben RC (2007) How not to be seen: immune-evasion strategies in gene therapy. Gene Ther 15:239–246
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Giacca, M. (2010). Introduction to Gene Therapy. In: Gene Therapy. Springer, Milano. https://doi.org/10.1007/978-88-470-1643-9_1
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DOI: https://doi.org/10.1007/978-88-470-1643-9_1
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-1642-2
Online ISBN: 978-88-470-1643-9
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