The idea to use “genes” as “drugs” for human therapy was originally conceived in the United States around the 1970s. It was the logical consequence of at least two major advancements that were occurring in those years, namely the exponentially growing knowledge of human gene function and the impact of their mutations, and the development of progressively more effective technologies for the delivery of DNA into mammalian cells.
KeywordsGene Therapy Gene Transfer Muscular Dystrophy Viral Vector Adenoviral Vector
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