Lymphoma: Diagnostic and Therapeutic Applications of Radiopharmaceuticals

  • Angelika Bischof Delaloye


Lymphoma is a heterogeneous family of diseases of the lymphatic system. There are two main entities, Hodgkin’s disease (HD) and non-Hodgkin’s lymphoma (NHL), the latter emerging either from B cells or T cells. Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) assisted by in-line CT (PET/CT) plays a pivotal role in patient management. HD shows high FDG uptake in close to 100% of the patients whereas FDG avidity greatly varies among patients with NHL subtypes. Aggressive lymphomas, such as diffuse large B cell lymphoma (DLBCL), the most current form of NHL, and mantle cell lymphomas (MCL) as well as Burkitt lymphomas and even plasmocytomas take up FDG very avidly. Follicular lymphomas (FL) also show high uptake in more than 90% of the cases whereas extranodal marginal zone lymphomas (MZL), such as splenic or mucosaassociated lymphoid tissue (MALT) MZL, are positive in only 67 and 54%, respectively [1].


Follicular Lymphoma Mantle Cell Lymphoma Focal Liver Lesion Primary Gastric Lymphoma Refractory Celiac Disease 


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Copyright information

© Springer Verlag Italia 2010

Authors and Affiliations

  • Angelika Bischof Delaloye
    • 1
  1. 1.Service de Médecine NucléaireCentre Hospitalier Universitaire VaudoisLausanneSwitzerland

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