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Integrated Imaging in Gastrointestinal Oncology: PET/CT Imaging

  • Thomas F. Hany

Abstract

The basic principle of positron emission tomography (PET) is the use of positron-emitting-isotope-labeled pharmaceuticals that are integrated into a metabolic pathway. Positron-emitting isotopes are characterized by a beta plus-decay, in which a positron is emitted. This positron collides with and annihilates any of the many shell electrons in the neighboring atoms, thereby producing two 511-keV gamma rays (photons) which are detected in coincidence by the PET scanner. The additional integration of a computed tomography scanner (PET/CT) allows the acquisition of PET and CT images of the patient in the same imaging session. The clinically and most widely evaluated positron-emitting isotope labeled pharmaceutical is fluorine-18 fluoro-2-deoxy-D-glucose (FDG). This glucose analogue is transported into the cell by specific transporters and phosphorylated by hexokinase to FDG-6-phosphate. As FDG-6-phosphate is inert to further metabolic processing or to transmembrane back-transport outside the cell, it accumulates within the cells. The physical half-life of FDG is around 110 min.

Keywords

Positron Emission Tomography Positron Emission Tomography Imaging Gastrointestinal Stromal Tumor Gallbladder Cancer Integrate Image 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Verlag Italia 2010

Authors and Affiliations

  • Thomas F. Hany
    • 1
  1. 1.Department of Radiology, Clinic and Policlinic of Nuclear MedicineUniversity Hospital ZurichZurichSwitzerland

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