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Integrated Imaging in Gastrointestinal Oncology: PET/CT Imaging

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Diseases of the Abdomen and Pelvis 2010–2013

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Abstract

The basic principle of positron emission tomography (PET) is the use of positron-emitting-isotope-labeled pharmaceuticals that are integrated into a metabolic pathway. Positron-emitting isotopes are characterized by a beta plus-decay, in which a positron is emitted. This positron collides with and annihilates any of the many shell electrons in the neighboring atoms, thereby producing two 511-keV gamma rays (photons) which are detected in coincidence by the PET scanner. The additional integration of a computed tomography scanner (PET/CT) allows the acquisition of PET and CT images of the patient in the same imaging session. The clinically and most widely evaluated positron-emitting isotope labeled pharmaceutical is fluorine-18 fluoro-2-deoxy-D-glucose (FDG). This glucose analogue is transported into the cell by specific transporters and phosphorylated by hexokinase to FDG-6-phosphate. As FDG-6-phosphate is inert to further metabolic processing or to transmembrane back-transport outside the cell, it accumulates within the cells. The physical half-life of FDG is around 110 min.

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Author information

Authors and Affiliations

  1. Department of Radiology, Clinic and Policlinic of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland

    Thomas F. Hany

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  1. Thomas F. Hany
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Editor information

Editors and Affiliations

  1. Radiology, University Hospital, Zurich, Switzerland

    J. Hodler

  2. Kilchberg/Zurich, Switzerland

    Ch. L. Zollikofer

  3. Nuclear Medicine, University Hospital, Zurich, Switzerland

    G. K. Von Schulthess

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Hany, T.F. (2010). Integrated Imaging in Gastrointestinal Oncology: PET/CT Imaging. In: Hodler, J., Zollikofer, C.L., Von Schulthess, G.K. (eds) Diseases of the Abdomen and Pelvis 2010–2013. Springer, Milano. https://doi.org/10.1007/978-88-470-1637-8_26

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  • DOI: https://doi.org/10.1007/978-88-470-1637-8_26

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1636-1

  • Online ISBN: 978-88-470-1637-8

  • eBook Packages: MedicineMedicine (R0)

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