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Enteral Antimicrobials

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Infection Control in the Intensive Care Unit

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Abstract

Selective decontaminationof the digestive tract (SDD) using enterally administered antimicrobials is now an evidence-based protocol. It is the best-ever evaluated intervention in intensive care medicine for reducing infectious morbidity and mortality. It is inexpensive and without side effects in terms resistance emergence. In intensive care units (ICUs) using enteral antimicrobials, gut carriage of potential pathogens, both sensitive and resistant, is significantly reduced with SDD. However, hand disinfection as a general hygiene procedure is still essential and can be expected to be more effective in ICUs where all long-stay patients are successfully decontaminated and are thus free from aerobic gram-negative bacilli (AGNB), yeast, and Staphylococcus aureus overgrowth, This subsequently reduces hand contamination and, consequently, the chance of transmission. SDD is the gold standard to which new manoeuvres of infection control should be compared.

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Authors and Affiliations

  1. Servicio de Medicina Intensiva, Hospital Clínico San Carlos Universidad Complutense, Madrid, Spain

    M. Sánchez García, M. Nieto Cabrera, M. A. González Gallego & F. Martínez Sagasti

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  1. M. Sánchez García
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  2. M. Nieto Cabrera
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  3. M. A. González Gallego
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  4. F. Martínez Sagasti
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Correspondence to M. Sánchez García .

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Editors and Affiliations

  1. , Institute of Aging and Chronic Diseases, University Liverpool, Daulby Street, Liverpool, L69 3GA, United Kingdom

    Hendrick K.F. van Saene

  2. , Dept. Emergency, Hospital Gorizia, Via Vittorio Veneto 171, Gorizia, 34170, Italy

    Luciano Silvestri

  3. , Department of Intensive Care Medicine, Hospital Universitario de Getafe, Carretera de Toledo km 12.5, Getafe, 28045, Spain

    Miguel A. de la Cal

  4. Policlinico di Catania, UCO di Anestesia e Rianimazione, Azienda Ospedaliero-Universitaria, Via Santa Sofia 78, Catania, 95100, Italy

    Antonino Gullo

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Sánchez García, M., Nieto Cabrera, M., González Gallego, M., Martínez Sagasti, F. (2011). Enteral Antimicrobials. In: van Saene, H., Silvestri, L., de la Cal, M., Gullo, A. (eds) Infection Control in the Intensive Care Unit. Springer, Milano. https://doi.org/10.1007/978-88-470-1601-9_8

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