Riassunto
L’angiogenesi è il processo di crescita di nuovi vasi intorno a un tessuto. La formazione di un neosubstrato vascolare assume un significato fisiologico nei processi di embriogenesi, di formazione di un corpo luteo e in molti altri che presuppongono la crescita di un neotessuto. La stessa assume un ruolo critico nella patogenesi di molte malattie, le più importanti delle quali sono senza dubbio i tumori solidi. Per quanto riguarda il cancro prostatico, il processo di angiogenesi è il principale responsabile della crescita rapida del neotessuto maligno e dell’acquisizione di capacità metastatiche del cancro. Con lo sviluppo contemporaneo di nuove strategie e di principi terapeutici che intervengano in modo specifico sul processo di angiogenesi, la possibilità di individuare e quantificare in modo accurato la crescita di neovasi passa dalla realtà dei laboratori alla pratica clinica routinaria.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Bibliografia
Folkman J (1990) What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82:4–6
Jain RK, Gerlowski LE (1986) Extravascular transport in normal and tumor tissues. Crit Rev Oncol Hematol 5:115–170
Weidner N (1995) Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol 147:9–19
Knopp MV, von Tengg-Koblingk H, Floemer F, Schoenberg SO (1999) Contrast agents for MRA: future directions. J Magn Reson Imaging 10:314–316
Saeed M, Wendland MF, Higgins CB (2000) Blood pool contrast agents for cardiovascular imaging. J Magn Reson Imaging 12:890–898
Aime S, Botta M, Fasano M et al (1996) Gd(III) complexes as contrast agents for magnetic resonance imaging: a proton relaxation enhancement study of the interaction with human serum albumin. J Biol Inorg Chem 1:312–319
Farooki A, Narra V, Brown J (2004) a. Curr Opin Investig Drugs 5:967–976
Anzidei M, Catalano C, Passariello R et al (2009) Gadofosveset-enhanced MR angiography of carotid arteries: does steady-state imaging improve accuracy of first-pass imaging? Comparison with selective digital subtraction angiography. Radiology 251(2):457–466
Caravan P, Cloutier NJ, Greenfield MT et al (2002) The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates. J Am Chem Soc 124:3152–3162
Rohrer M, Bauer H, Mintorovitch J et al (2005) Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths. Invest Radiol 40: 715–724
Grist TM, Korosec FR, Peters DC et al (1998) Steady-state and dynamic MR angiography with MS-325: initial experience in humans. Radiology 207:539–544
Preda A, Novikov V, Möglich M et al (2004) MRI monitoring of Avastin antiangiogenesis therapy using B22956/1, a new blood pool contrast agent, in an experimental model of human cancer. J Magn Reson Imaging 20:865–873
Stefanou D, Batistatou A, Kamina S et al (2004) Expression of vascular endothelial growth factor (VEGF) and association with microvessel density in benign prostatic hyperplasia and prostate cancer. In Vivo 18(2):155–160
Sinha AA, Quast BJ, Reddy PK et al (2004) Microvessel density as a molecular marker for identifying high-grade prostatic intraepithelial neoplasia precursors to prostate cancer. Exp Mol Pathol 77(2):153–159
Bono AV, Celato N, Cova V et al (2002) Microvessel density in prostate carcinoma. Prostate Cancer Prostatic Dis 5(2): 123–127
van Niekerk CG, van der Laak JA, Börger ME et al (2009) Computerized whole slide quantification shows increased microvascular density in pT2 prostate cancer as compared to normal prostate tissue. Prostate 69(1):62–69
Cheng HL, Wallis C, Shou Z, Farhat WA (2007) Quantifying angiogenesis in VEGF-enhanced tissue-engineered bladder constructs by dynamic contrast-enhanced MRI using contrast agents of different molecular weights. J Magn Reson Imaging 25(1):137–145
Roberts T, Schwickert H, Brasch R (1995) Quantitative estimation of contrast agent tissue accumulation: potential errors, Soc Magn Reson Proc, Nice, France, p 1129
Kaiser W, Reisner M (1992) False positive cases in dynamic MR mammography. RSNA, Chicago, p 934
Ostrowitzki S, Fick J, Roberts TP et al (1998) Comparison of gadopentetate dimeglumine and albumin-(Gd-DTPA)30 for microvessel characterization in an intracranial glioma model. J Magn Reson Imaging 8:799–806
Daldrup H, Shames D, Wendland M et al (1998) Correlation of dynamic contrast-enhanced magnetic resonance imaging with histologic tumor grade: comparison of macromolecular and small molecular contrast media. Am J Roentgen 171:941–949
Ocak I, Bernardo M, Metzger G et al (2007) Dynamic contrast-enhanced MRI of prostate cancer at 3 T: a study of pharmacokinetic parameters. AJR Am J Roentgenol 189(4): 849
Noworolski SM, Vigneron DB, Chen AP, Kurhanewicz J (2008) Dynamic contrast-enhanced MRI and MR diffusion imaging to distinguish between glandular and stromal prostatic tissues. Magn Reson Imaging 26:1071–1080. Epub 2008 May 27
Zakian KL, Shukla-Dave A, Ackerstaff E (2008) 1H magnetic resonance spectroscopy of prostate cancer: biomarkers for tumor characterization. Cancer Biomark 4(4–5): 263–276
Vilanova JC, Barceló J (2007) Prostate cancer detection: magnetic resonance (MR) spectroscopic imaging. Abdom Imaging 32(2):253–261
Taouli B (2006) MR spectroscopic imaging for evaluation of prostate cancer. J Radiol 87(2 Pt 2):222–227
Huzjan R, Sala E, Hricak H (2005) Magnetic resonance imaging and magnetic resonance spectroscopic imaging of prostate cancer. Nat Clin Pract Urol 2(9):434–442
Vogel-Claussen J, Gimi B, Artemov D, Bhujwalla ZM (2007) Diffusion-weighted and macromolecular contrast enhanced MRI of tumor response to antivascular therapy with ZD6126. Cancer Biol Ther 6(9):1469–1475
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Italia
About this chapter
Cite this chapter
Osimani, M., Ricci, P., Panebianco, V. (2010). Impiego dei mezzi di contrasto intravascolari. In: Passariello, R., Panebianco, V., Di Silverio, F., Sciarra, A. (eds) Imaging RM della prostata. Springer, Milano. https://doi.org/10.1007/978-88-470-1516-6_28
Download citation
DOI: https://doi.org/10.1007/978-88-470-1516-6_28
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-1515-9
Online ISBN: 978-88-470-1516-6
eBook Packages: MedicineMedicine (R0)