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Characterization of Acoustic Properties of PVA-Shelled Ultrasound Contrast Agents

  • Dmitry Grishenkov
  • Claudio Pecorari
  • Torkel B. Brismar
  • Gaio Paradossi

Abstract

This work examines the acoustic behavior of ultrasound contrast agents made of poly (vinyl alcohol) (PVA) shelled microbubbles manufactured at three different pH and temperature conditions. Backscattering amplitude, attenuation coefficient and phase velocity of ultrasonic waves propagating through suspensions of PVA contrast agents were measured at temperature values ranging from 24°C to 37°C in a frequency range from 3 MHz to 13 MHz. A significant enhancement of the backscattering amplitude and a weak dependence on temperature were observed. Attenuation and phase velocity, on the other hand, showed higher sensitivity to temperature variations. The dependence on system parameters such as the number of cycles, frequency, and exposure of the peak negative pressure, P thr , at which ultrasound contrast agents fracture was also investigated. The effects of temperature, blood, and, whenever data were available, of the dimension of the microbubbles on P thr are also considered. The large shell thickness notwithstanding, the results of this investigation show that at room temperature, PVA contrast agents fracture at negative peak pressure values within the recommended safety limit. Furthermore, P thr decreases with increasing temperature, radius of the microbubbles, and number of cycles of the incident wave. In conclusion, these results suggest that PVA-shelled microbubbles may offer a potentially viable system to be employed for both imaging and therapeutic purposes.

Keywords

Contrast Agent Phase Velocity Ultrasonic Wave Acoustic Property Pulse Repetition Frequency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Cavalieri F, El Hamassi A, Chiessi E and Paradossi G (2005) Stable Polymeric Microballoons as Multifunctional Device for Biomedical Uses: Synthesis and Characterization. Langmuir 21(19):8758–8764CrossRefGoogle Scholar
  2. 2.
    Chen WS, Matula TJ, Brayman AA and Crum LA (2003) A comparison of the fragmentation thresholds and inertial cavitation doses of different ultrasound contrast agents. J Acoust Soc Am 113:643–651CrossRefGoogle Scholar
  3. 3.
    Church C (1995) The effect of an elastic solid surface layer on the radial pulsations of gas bubbles. J Acoust Soc Am 97(3):1510–1521CrossRefGoogle Scholar
  4. 4.
    Grishenkov D, Pecorari C, Brismar TB and Paradossi G (2009) Characterization of acoustic properties of PVA-shelled ultrasound contrast agents: linear properties (Part I). Ultrasound Med Biol. In printGoogle Scholar
  5. 5.
    Lathia JD, Leodore L and Wheatley MA (2004) Polymeric contrast agent with targeting potential. Ultrasonics 42:763–768CrossRefGoogle Scholar
  6. 6.
    Lavisse S, Rouffiac V, Peronneau P, Paci A, Chaix C, Reb P, Roche A and Lassau N (2008) Acoustic characterization of a new trisacryl contact agent. Part I: In vitro study. Ultrasonics 48:16–25CrossRefGoogle Scholar
  7. 7.
    Pecorari C and Grishnkov D (2007) Characterization of ultrasound-induced fracture of polymer-shelled ultrasonic contrast agents by correlation analysis. J Acoust Soc Am 122:2425–2430CrossRefGoogle Scholar
  8. 8.
    Wheatley MA, Forsberg F, Oum K, Ro R and El-Sherif D (2006) Comparison of in vitro and in vivo acoustic response of a novel 50:50 PLGA contrast agents. Ultrasonics 44:360–367CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2010

Authors and Affiliations

  • Dmitry Grishenkov
    • 1
  • Claudio Pecorari
    • 2
  • Torkel B. Brismar
    • 3
  • Gaio Paradossi
    • 4
  1. 1.Marcus Wallenberg LaboratoryRoyal Institute of TechnologyStockholmSweden
  2. 2.VästeråsSweden
  3. 3.Department of RadiologyKarolinska InstitutetStockholmSweden
  4. 4.Dipartimento di Scienze e Tecnologie ChimicheUniversità di Roma Tor VergataRomaItaly

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