A Comparative Analysis of Contrast Enhanced Ultrasound Imaging Techniques

  • Andrea Trucco
  • Marco Crocco
  • Anastasis Kounoudes
  • Claudia Sciallero


One of the most important issues in the field of ultrasound medical imaging using contrast agents is the development of techniques able to separate the response of contrast media from the response of biological tissues. In the literature, one can find various solutions concerning the use of multiple transmitted signals and the combination of the related echoes. Moreover, such multi-pulse techniques can be combined with a coded excitation in order to increase both the contrast to tissue ratio and the signal to noise ratio. The effectiveness of these techniques depends on many parameters concerning the medical ultrasound device and the physical scenario involved. In particular, some undesired effects always present in real conditions, like the signal distortion caused by the hardware equipment and by non-linear tissue propagation, the thermal noise, and the tissue movements can significantly reduce the theoretical performance. In this chapter a simulation tool is proposed that allows one to calculate the backscattered echo from a population of contrast agents immersed in a biological tissue, considering all the mentioned effects. With this tool, an assessment of the performance of a set of multi-pulse techniques has been carried out under realistic working conditions, showing that sharp differences occur among the techniques, depending on the specific setup considered.


Simulation Tool Thermal Noise Beam Signal Ultrasound Contrast Agent Pulse Inversion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia 2010

Authors and Affiliations

  • Andrea Trucco
    • 1
  • Marco Crocco
    • 1
  • Anastasis Kounoudes
    • 2
  • Claudia Sciallero
    • 1
  1. 1.Dept. of Biophysical and Electronic EngineeringUniversity of GenoaGenoaItaly
  2. 2.SignalGeneriX LtdLimassolCyprus

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