Locoregional Therapies and Surgical Oncology

  • Carlo Riccardo Rossi
  • Alessandro Comandone
  • Andrea Veltri
Part of the Updates in Surgery book series (UPDATESSURG)


The natural history of solid neoplasms starts as a confined disease in a specific anatomical area. This period varies greatly in length and involves carcinoma in situ as well as the stage I–II of the disease. In localized disease surgery is the mainstay. Radiotherapy can play a curative role in specific situations, but in general, together with chemotherapy it is an adjuvant treatment.


Cytoreductive Surgery Isolate Limb Perfusion Hepatic Arterial Infusion Microwave Ablation Locoregional Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ensminger WD (2001) Intraarterial therapy. In: Perry CM (ed) The chemotherapy source book, 3rd edn: Lippincott Williams & Wilkins, Philadelphia, pp 163–174Google Scholar
  2. 2.
    Rossi CR, Foletto M, Pilati P et al (2002) Isolated limb perfusion in locally advanced cutaneous melanoma. Semin Oncol 29:400–409CrossRefPubMedGoogle Scholar
  3. 3.
    Markman M (1998) Intraperitoneal therapy in ovarian cancer. Semin Oncol 25:356–360PubMedGoogle Scholar
  4. 4.
    Alexander HR, Kemeny NE, Lawrence TS (2005) Metastatic cancer to the liver. In: De Vita VT, Hellmann S, Rosenberg SA (eds) Cancer principles & practice of oncology. 7th edn. Lippincott Williams & Wilkins, Philadelphia, pp 2352–2367Google Scholar
  5. 5.
    Lise M, Pilati P, Da Pian P et al (2003) Treatment options for liver metastases from colorectal cancer. J Exp Clin Cancer Res 22:149–156PubMedGoogle Scholar
  6. 6.
    Kemeny N (2007) Presurgical chemotherapy in patients being considered for liver resection. Oncologist 12:825–839CrossRefPubMedGoogle Scholar
  7. 7.
    Vadeyar HJ (2007) Current therapeutic options for colorectal liver metastases. Indian J Gastroenterol 26:26–29PubMedGoogle Scholar
  8. 8.
    Rossi CR, Foletto M, Pilati P et al (2002) Isolated limb perfusion in locally advanced cutaneous melanoma. Semin Oncol 29:400–409CrossRefPubMedGoogle Scholar
  9. 9.
    Rossi CR, Foletto M, Mocellin S (2004) Hyperthermic isolated limb perfusion with low-dose tumor necrosis factor-alpha and melphalan for bulky in-transit melanoma metastases. Ann Surg Oncol 11:173–177CrossRefPubMedGoogle Scholar
  10. 10.
    Di Filippo F, Rossi CR, Santinami M et al (2006) Hyperthermic isolation limb perfusion with TNFalpha in the treatment of in-transit melanoma metastasis. In Vivo 20:739–742PubMedGoogle Scholar
  11. 11.
    Hayes AJ, Neuhaus SJ, Clark MA, Thomas JM (2007) Isolated limb perfusion with melphalan and tumor necrosis factor alpha for advanced melanoma and soft-tissue sarcoma. Ann Surg Oncol 14:230–238CrossRefPubMedGoogle Scholar
  12. 12.
    Eggermont AM, Schraffordt Koops H, Klausner JM et al (1996) Isolated limb perfusion with tumor necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas. The cumulative multicenter European experience. Ann Surg 224:756–764CrossRefPubMedGoogle Scholar
  13. 13.
    Noorda EM, Vrouenraets BC, Nieweg OE et al (2003) Isolated limb perfusion with tumor necrosis factor-alpha and melphalan for patients with unresectable soft tissue sarcoma of the extremities. Cancer 98:1483–1490CrossRefPubMedGoogle Scholar
  14. 14.
    Gutman M, Inbar M, Lev-Shlush D et al (1997) High dose tumor necrosis factor-alpha and melphalan administered via isolated limb perfusion for advanced limb soft tissue sarcoma results in a <90% response rate and limb preservation. Cancer 79:1129–1137CrossRefPubMedGoogle Scholar
  15. 15.
    Cherix S, Speiser M, Matter M et al (2008) Isolated limb perfusion with tumor necrosis factor and melphalan for non-resectable soft tissue sarcomas: long-term results on efficacy and limb salvage in a selected group of patients. J Surg Oncol 98:148–155CrossRefPubMedGoogle Scholar
  16. 16.
    Hess LM, Benham-Hutchins M, Herzog TJ et al (2007) A meta-analysis of the efficacy of intraperitoneal cisplatin for the front-line treatment of ovarian cancer. Int J Gynecol Cancer 17:561–570CrossRefPubMedGoogle Scholar
  17. 17.
    Noma J, Yoshida N (2008) Intraperitoneal chemotherapy for ovarian cancer. Gan To Kagaku Ryoho 35:885–890PubMedGoogle Scholar
  18. 18.
    Xu DZ, Zhan YQ, Sun XW et al (2004) Meta-analysis of intraperitoneal chemotherapy for gastric cancer. World J Gastroenterol 10):2727–2730PubMedGoogle Scholar
  19. 19.
    Moran B, Baratti D, Yan TD et al (2008) Consensus statement on the loco-regional treatment of appendiceal mucinous neoplasms with peritoneal dissemination (pseudomyxoma peritonei). J Surg Oncol 98:277–282CrossRefPubMedGoogle Scholar
  20. 20.
    Deraco M, Bartlett D, Kusamura S, Baratti D (2008) Consensus statement on peritoneal mesothelioma. J Surg Oncol 98:268–272CrossRefPubMedGoogle Scholar
  21. 21.
    Esquivel J, Elias D, Baratti D et al (2008) Consensus statement on the loco regional treatment of colorectal cancer with peritoneal dissemination. J Surg Oncol 98:263–267CrossRefPubMedGoogle Scholar
  22. 22.
    Helm CW, Bristow RE, Kusamura S et al (2008) Hyperthermic intraperitoneal chemotherapy with and without cytoreductive surgery for epithelial ovarian cancer. J Surg Oncol 98:283–290CrossRefPubMedGoogle Scholar
  23. 23.
    Bozzetti F, Yu W, Baratti D et al (2008) Locoregional treatment of peritoneal carcinomatosis from gastric cancer. J Surg Oncol 98:273–276CrossRefPubMedGoogle Scholar
  24. 24.
    Mir LM, Orlowski S (1999) Mechanisms of electrochemotherapy. Adv Drug Del Rev 35:107–118CrossRefGoogle Scholar
  25. 25.
    Marty M, Sersa G, Garbay JR et al (2006) Electrochemotherapy—An easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: results of ESOPE study. EJC[Suppl] 4:3–13Google Scholar
  26. 26.
    Campana LG, Mocellin S, Basso M et al (2009) Bleomycin-based electrochemotherapy: clinical outcome from a single institution’s experience with 52 patients. Ann Surg Oncol 16:191–199CrossRefPubMedGoogle Scholar
  27. 27.
    Goldberg SN, Grassi CJ, Cardella JF et al (2005) Image-guided tumor ablation: standardization of terminology and reporting criteria. Radiology 235:728–739CrossRefPubMedGoogle Scholar
  28. 28.
    Bruix J, Sherman M (2005) Management of hepatocellular carcinoma. Hepatology 42:1208–1236CrossRefPubMedGoogle Scholar
  29. 29.
    Brunello F, Veltri A, Carucci P et al (2008) Radiofrequency ablation versus ethanol injection for early hepatocellular carcinoma: a randomized controlled trial. Scand J Gastroenterol 43:727–735CrossRefPubMedGoogle Scholar
  30. 30.
    Veltri A, Moretto P, Doriguzzi A et al (2006) Radiofrequency thermal ablation (RFA) after transarterial chemoembolization (TACE) as a combined therapy for unresectable non-early hepatocellular carcinoma (HCC). Eur Radiol 16:661–669CrossRefPubMedGoogle Scholar
  31. 31.
    Veltri A, Sacchetto P, Tosetti I et al (2008) Radiofrequency ablation of colorectal liver metastases: small size favorably predicts technique effectiveness and survival. Cardiovasc Intervent Radiol 31:948–956CrossRefPubMedGoogle Scholar
  32. 32.
    Lencioni R, Crocetti L, Cioni R et al (2008) Response to radiofrequency ablation of pulmonary tumors: a prospective, intention-to-treat, multicentre clinical trial (the RAPTURE study). Lancet Oncol 9:621–628CrossRefPubMedGoogle Scholar
  33. 33.
    Veltri A, Garetto I, Pagano E et al (2009) Percutaneous RF thermal ablation of renal tumors: is US guidance really less favorable than other imaging guidance techniques? Cardiovasc Intervent Radiol 32:76–85CrossRefPubMedGoogle Scholar
  34. 34.
    Veltri A, Calvo A, Tosetti I et al (2006) Experiences in US-guided percutaneous radio frequency ablation of 44 renal tumors in 31 patients: analysis of predictors for complications and technical success. Cardiovasc Intervent Radiol 29:811–818CrossRefPubMedGoogle Scholar
  35. 35.
    Goetz MP, Callstrom MR, Charboneau JW et al (2004) Percutaneous image-guided radio frequency ablation of painful metastases involving bone: a multicenter study. J Clin Oncol 22:300–306CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia 2010

Authors and Affiliations

  • Carlo Riccardo Rossi
    • 1
  • Alessandro Comandone
    • 2
  • Andrea Veltri
    • 3
  1. 1.Sarcoma and Melanoma Unit, Clinica Chirurgica IIUniversity of PaduaPaduaItaly
  2. 2.Department of Medical OncologyGradenigo HospitalTurinItaly
  3. 3.Institute of RadiologyS. Luigi Hospital University of TurinTurinItaly

Personalised recommendations