Advertisement

Transplants in Surgical Oncology

  • Mauro Salizzoni
  • Giulia Carbonaro
  • Lorenzo Repetto
Part of the Updates in Surgery book series (UPDATESSURG)

Abstract

In 1967 Thomas Starzl performed the first orthotopic liver transplant (OLT) in Denver. Since 1990 OLT has been the main therapy for every form of terminal liver failure, including hepatocellular carcinoma (HCC). In 1996 Mazzaferro published the results obtained on selected patients affected with HCC. He showed a 4 year survival rate of 75%, comparable to the rate obtained on patients who were transplanted for non tumoral pathology (78.3%) [1].

Keywords

Liver Transplantation Live Donor Liver Transplantation Bladder Carcinoma Hilar Cholangiocarcinoma Milan Criterion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Mazzaferro V, Regalia E, Doci R et al (1996) Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrosi. N Engl J Med 334:693CrossRefPubMedGoogle Scholar
  2. 2.
    Yao FY, Ferrel L, Bass NM et al (2001) Liver transplantation for hepatocellular carcinoma: expansion of tumor size limits does not adversely impact survival. Hepatology 33:1394CrossRefPubMedGoogle Scholar
  3. 3.
    Llovet JM, Bruix J (2008) Molecular targeted therapies in hepatocellular carcinoma. Hepatology 48:1312–1327CrossRefPubMedGoogle Scholar
  4. 4.
    Ringe B, Wittekind C, Weimann A et al (1992) Results of hepatic resection and transplantation for fibrolamellar carcinoma. Surg Gynecol Obstet 175:299–305PubMedGoogle Scholar
  5. 5.
    El Gazzaz G, Wong W, El Hadary MK et al (2000) Outcome of liver resection and transplantation for fibrolamellar hepatocellular carcinoma. Transpl Int 13[Suppl 1]:S406–S409CrossRefPubMedGoogle Scholar
  6. 6.
    Schlitt HJ, Neipp M, Weimann A et al (1999) Recurrence patterns of hepatocellular and fibrolamellar carcinoma after liver transplantation. J Clin Oncol 17:324–331PubMedGoogle Scholar
  7. 7.
    Otte JB, de Ville de Goyet J (2005) The contribution of transplantation to the treatment of liver tumors in children. Semin Pediat Surg 14:233–238CrossRefGoogle Scholar
  8. 8.
    Otte JB, Prichard J, Arason DC et al (2004) Liver transplantation for hepatoblastoma: results from the International Society of Pediatric Oncology (SIOP) study SIOPEL 1 and review of the world experience. Pediatr Blood Cancer 452:74–83CrossRefGoogle Scholar
  9. 9.
    Jonas S, Benckert C, Thelen A et al (2008) Radical surgery for hilar cholangiocarcinoma. Eur J Surg Oncol 34:263–271PubMedGoogle Scholar
  10. 10.
    De Vreede I, Steers JL, Burch PA et al (2000) Prolonged disease-free survival after orthotopic liver transplantation plus adjuvant chemoirradiation for cholangiocarcinoma. Liver Transpl 6:309–316CrossRefPubMedGoogle Scholar
  11. 11.
    Rosenau J, Bahr MJ, von Wasielewski R et al (2002) Ki67, E-cadherin, and p53 as prognostic indicators of long-term outcome after liver transplantation for metastatic neuroendocrine tumors. Transplantation 73:386–394CrossRefPubMedGoogle Scholar
  12. 12.
    Coppa J, Pulvirenti A, Schiavo M et al (2001) Resection versus transplantation for liver metastases from neuroendocrine tumors. Transplant Proc 33:1537–1539CrossRefPubMedGoogle Scholar
  13. 13.
    Cahlin C, Friman S, Ahlman H et al (2003) Liver transplantation for metastatic neuroendocrine tumor disease. Transpl Proc 35:809–810CrossRefGoogle Scholar
  14. 14.
    Cameron S, Ramadori G, Fuzesi L et al (2005) Successful liver transplantation in two cases of metastatic gastrointestinal stromal tumor. Transplantation 2005:80 283–284Google Scholar
  15. 15.
    Monaco AP (2009) The role of mTOR inhibitors in the management of posttransplant malignancy. Transplantation 87:157–163CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia 2010

Authors and Affiliations

  • Mauro Salizzoni
    • 1
  • Giulia Carbonaro
    • 1
  • Lorenzo Repetto
    • 2
  1. 1.Liver Translantation Unit-General Surgery 8S. Giovanni Battista University HospitalTurinItaly
  2. 2.Urology Unit IIIS. Giovanni Battista University HospitalTurinItaly

Personalised recommendations