• Marina Rizzi
Part of the Updates in Surgery book series (UPDATESSURG)


Epidemiology studies the frequency of illness and in some cases can suggest causes and mechanisms for chronic idiopathic diseases, including Crohn’s disease (CD). One well-received current hypothesis for the etiology of inflammatory bowel diseases (IBD) is a genetic predisposition to dysregulation of the gastrointestinal immune system. This possibility is supported by studies of monozygotic twins, in which the concordance of CD is 50–60%. However, the remaining 50% are discordant for CD, suggesting that environmental factors also play an important role in disease development.


Inflammatory Bowel Disease Ulcerative Colitis Mycobacterium Avium Subspecies Paratuberculosis Olmsted County Passive Cigarette Smoke 
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  1. 1.
    Loftus EV Jr, Sandborn WJ (2002) Epidemiology of inflammatory bowel disease. Gastroenterol Clin North Am 31:1–20CrossRefPubMedGoogle Scholar
  2. 2.
    Shivananda S, Lennard-Jones J, Logan R et al (1996) Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD). Gut 39:690–697CrossRefPubMedGoogle Scholar
  3. 3.
    Bjornsson S, Johannsson JH (2000) Inflammatory bowel disease in Iceland, 1990–1994: a prospective, nationwide, epidemiological study. Eur J Gastroenterol Hepatol 12:31–33CrossRefPubMedGoogle Scholar
  4. 4.
    Yapp TR, Stenson R, Thomas GAO et al (2000) Crohn’s disease incidence in Cardiff from 1930: an update for 1991–1995. Eur J Gastroenterol Hepatol 12:907–911CrossRefPubMedGoogle Scholar
  5. 5.
    Rubin GP, Hungin APS, Kelly PJ, Ling J (2000) Inflammatory bowel disease: epidemiology and management in an English general practice population. Aliment Pharmacol Ther 14:1553–1559CrossRefPubMedGoogle Scholar
  6. 6.
    Kurata JH, Kantor-Fish S, Frankl H et al (1992) Crohn’s disease among ethnic groups in a large health maintenance organization. Gastroenterology 102:1940–8194.PubMedGoogle Scholar
  7. 7.
    Loftus EV Jr, Silverstein MD, Sandborn WJ et al (1998) Crohn’s disease in Olmsted County. Minnesota, 1940–1993: incidence, prevalence, and survival [published erratum appears in Gastroenterology (1999) 116:1507. Gastroenterology 114:1161–1168CrossRefPubMedGoogle Scholar
  8. 8.
    Bernstein CN, Blanchard JF, Rawsthorne P, Wajda A (1999) Epidemiology of Crohn’s disease and ulcerative colitis in a central Canadian province: a population-based study. Am J Epidemiol 149:916–924PubMedGoogle Scholar
  9. 9.
    Loftus EV Jr, Silverstein MD, Sandborn WJ et al (2000) Ulcerative colitis in Olmsted County, Minnesota, 1940–1993: incidence, prevalence, and survival. Gut 46:336–343CrossRefPubMedGoogle Scholar
  10. 10.
    Loftus CG, Loftus EV, Sandborn WJ et al (2003) Update on incidence and prevalence of Crohn’s disease and ulcerative colitis in Olmsted County, Minnesota (abstr) Gastroenterology 124:A36Google Scholar
  11. 11.
    Manousos ON, Koutroubakis I, Potamianos S et al (1996) A prospective epidemiologic study of Crohn’s disease in Heraklion, Crete. Incidence over a 5-year period. Scand J Gastroenterol 31:599–603CrossRefPubMedGoogle Scholar
  12. 12.
    Trallori G, Palli D, Saieva C et al (1996) A population-based study of inflammatory bowel disease in Florence over 15 years (1978–92). Scand J Gastroenterol 31:892–899CrossRefPubMedGoogle Scholar
  13. 13.
    Tragnone A, Corrao G, Miglio F et al (1996) Incidence of inflammatory bowel disease in Italy: a nationwide population-based study. Intl J Epidemiol 25:1044–1052CrossRefGoogle Scholar
  14. 14.
    Lee YM, Fock KM, See SJ et al (2000) Racial differences in the prevalence of ulcerative colitis and Crohn’s disease in Singapore J Gastroenterol Hepatol 15:622–625CrossRefPubMedGoogle Scholar
  15. 15.
    Linares de la Cal JA, Canton C, Hermida C et al (1999) Estimated incidence of inflammatory bowel disease in Argentina and Panama (1987–1993). Rev Esp Enferm Dig 91:277–286PubMedGoogle Scholar
  16. 16.
    Ekborn A (2003) The changing faces of Crohn’s disease and ulcerative colitis. In: Targan SR, Shanahan F, Karp LC et al (eds) Inflammatory bowel disease, from bench to bedside. Dordrecht: Kluwer Academic, pp. 5–21Google Scholar
  17. 17.
    Lakatos L, Lakatos PL (2006) Is the incidence and prevalence of inflammatory bowel disease increasing in Western Europe? Postgrad Med J 82:332–337CrossRefPubMedGoogle Scholar
  18. 18.
    Yang SK, Loftus EV, Sandborn WJ (2001) Epidemiology of Inflammatory Bowel Disease in Asia. Inflammatory Bowel Diseases 7(3):260–270CrossRefPubMedGoogle Scholar
  19. 19.
    Loftus CG, Loftus EV, Harmsen WS et al (2007) Update on the incidence and prevalence of Crohn’s disease and ulcerative colitis in Olmsted County, Minnesota, 1940–2000. Inflamm Bowel Dis 14:254–261CrossRefGoogle Scholar
  20. 20.
    Blanchard JF, Bernstein CN, Wajda A, Rawsthorne P (2001) Small-area variations and sociodemographic correlates for the incidence of Crohn’s disease and ulcerative colitis. Am J Epidemiol 154:328–335CrossRefPubMedGoogle Scholar
  21. 21.
    Sawczenko A, Sandhu BK, Logan RFA et al (2001) Prospective survey of childhood inflammatory bowel disease in the British Isles. Lancet 357:1093–1094CrossRefPubMedGoogle Scholar
  22. 22.
    Fellows IW, Freeman JG, Holmes GK (1990) Crohn’s disease in the city of Derby, 1951–85. Gut 31:1262–1265CrossRefPubMedGoogle Scholar
  23. 23.
    Ramcharan S (1981) The Walnut Creek Contraceptive Drug Study: a prospective study of the side effects of oral contraceptives. DHEW Publication No. 74-562. US Government Printing Office, Washington DCGoogle Scholar
  24. 24.
    Vessey M, Jewell D, Smith A et al (1986) Chronic inflammatory bowel disease, cigarette smoking, and use of oral contraceptives: findings in a large cohort study of women of childbearing age. BMJ 292:1101–1103CrossRefPubMedGoogle Scholar
  25. 25.
    Godet PG, May GR, Sutherland LR (1995) Meta-analysis of the role of oral contraceptive agents in inflammatory bowel disease. Gut 37:668–673CrossRefPubMedGoogle Scholar
  26. 26.
    Boyko EJ, Theis MK, Vaughan TL, Nicol-Blades B (1994) Increased risk of inflammatory bowel disease associated with oral contraceptive use. Am J Epidemiol 140:268–278PubMedGoogle Scholar
  27. 27.
    Timmer A, Sutherland LR, Martin F (1998) Oral contraceptive use and smoking are risk factors for relapse in Crohn’s disease. Gastroenterology 114:1143–115CrossRefPubMedGoogle Scholar
  28. 28.
    Cosnes J, Carbonnel F, Carrat F et al (1999) Oral contraceptive use and the clinical course of Crohn’s disease: a prospective cohort study. Gut 45:218–222CrossRefPubMedGoogle Scholar
  29. 30.
    Lacut K, Mottier D, Pottier P (2008) Drugs and venous thromboembolism. Rev Pneumol Clin 64(6):290–297CrossRefPubMedGoogle Scholar
  30. 31.
    Loftus EV Jr, choenfeld P, Sandborn WJ (2002) The epidemiology and natural history of Crohn’s disease in population-based patient cohorts from North America: a systematic review. Aliment Pharmacol Ther 16:51–60CrossRefPubMedGoogle Scholar
  31. 32.
    Calkins BM (1989) A meta-analysis of the role of smoking in inflammatory bowel disease. Dig Dis Sci 34:1841–1854CrossRefPubMedGoogle Scholar
  32. 33.
    Reif S, Lavy A, Keter D et al (2000) Lack of association between smoking and Crohn’s disease but the usual association with ulcerative colitis in Jewish patients in Israel: a multicenter study. Am J Gastroenterol 95:474–478CrossRefPubMedGoogle Scholar
  33. 34.
    Russel MG, Volovics A, Schoon EJ et al (1998) Inflammatory bowel disease: is there any relation between smoking status and disease presentation? Inflamm Bowel Dis 4:182–186PubMedGoogle Scholar
  34. 35.
    Picco MF, Bayless TM (2003) Tobacco consumption and disease duration are associated with fistulizing and stricturing behaviors in the first 8 years of Crohn’s disease. Am J Gastroenterol 98:363–368CrossRefPubMedGoogle Scholar
  35. 36.
    Sutherland LR, Ramcharan S, Bryan H, Fick G (1990) Effect of cigarette smoking on recurrence of Crohn’s disease. Gastroenterology 98:1123–1128PubMedGoogle Scholar
  36. 37.
    Cosnes J, Carbonnel F, Carrat F et al (1999) Effect of current and former cigarette smoking on the clinical course of Crohn’s disease. Aliment Pharmacol Ther 13:1403–1411CrossRefPubMedGoogle Scholar
  37. 38.
    Cosnes J, Beaugerie L, Carbonnel F, Gendre JP (2001) Smoking cessation and the course of Crohn’s disease: an intervention study. Gastroenterology 120:1093–1099CrossRefPubMedGoogle Scholar
  38. 39.
    Lindberg E, Jarnerot G, Huitfeldt B (1992) Smoking in Crohn’s disease: effect on localisation and clinical course. Gut 33:779–782CrossRefPubMedGoogle Scholar
  39. 40.
    Radford-Smith GL (2003) The role of the appendix and appendectomy in patients with IBD. IBD Monitor 4:120–128Google Scholar
  40. 41.
    Martini GA, Brandes JW (1976) Increased consumption of refined carohydrates in patients with Crohn’s disease. Klin Wochen 54:367–371CrossRefGoogle Scholar
  41. 42.
    Riordan AM, Ruxton CH, Hunter JO (1998) A review of associations between Crohn’s disease and consumtpion of sugars. Eur J Clin Nutr 52:229–338CrossRefPubMedGoogle Scholar
  42. 43.
    Ekbom A, Adami HO, Helmick CG et al (1990) Perinatal risk factors for inflammatory bowel disease: a case-control study. Am J Epidemiol 132:1111–1119PubMedGoogle Scholar
  43. 44.
    Greenstein RJ (2003) Is Crohn’s disease caused by a mycobacterium? Comparisons with leprosy, tuberculosis, and Johne’s disease. Lancet Infect Dis 3:507–514CrossRefPubMedGoogle Scholar
  44. 45.
    Chiodini RJ, Van Kruingngen HJ, Merkal RS et al (1984) Characteristics of an unclassified Mycobacterium species isolated from patients with Crohn’s disease. J Clin Microbiol 20:966–971PubMedGoogle Scholar
  45. 46.
    Van Kruiningen HJ (1999) Lack of support for a common etiology in Johne’s disease of animals and Crohn’s disease in humans. Inflamm Bowel Dis 5:183–191PubMedCrossRefGoogle Scholar
  46. 47.
    Shafran I, Kugler L, El-Zaatari FA et al (2002) Open clinical trial of rifabutin and clarithromycin therapy in Crohn’s disease. Dig Liver Dis 34:22–28CrossRefPubMedGoogle Scholar
  47. 48.
    Borody TJ, Leis S, Warren EF, Surace R (2002) Treatment of severe Crohn’s disease using antimycobacterial triple therapy—approaching a cure? Dig Liver Dis 34:29–38CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia 2010

Authors and Affiliations

  • Marina Rizzi
    • 1
  1. 1.Gastroenterology UnitUniversity Campus Bio MedicoRomeItaly

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