Crohn’s Disease in Children

  • Salvatore Cucchiara
  • Laura Stronati
Part of the Updates in Surgery book series (UPDATESSURG)


Although Crohn’s disease occurring in adults and in childhood share the same immuno-pathogenetic mechanism and genetic background, as well as diagnostic modalities and therapeutic strategies, aspects pertaining to all these variables make the disorder in children a peculiar entity. Children with Crohn’s disease represent a unique patient population to investigate the initial intestinal immune response and to characterize the genotype-phenotype relationship, the natural history of the disease, the intervention of environmental factors, and the early introduction of therapeutic immunomodulators and biologicals to alter the natural course of the disease.


Inflammatory Bowel Disease Ulcerative Colitis Patient Perianal Disease Indeterminate Colitis Pediatric Inflammatory Bowel Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia 2010

Authors and Affiliations

  • Salvatore Cucchiara
    • 1
  • Laura Stronati
    • 2
  1. 1.Pediatric Gastroenterology and Liver UnitSapienza UniversityRomeItaly
  2. 2.Section of Toxicology and Biomedical SciencesENEARomeItaly

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