Abstract
After demonstration of a positive correlation between sodium intake and arterial pressure in large population studies, the effect of rather short-term reduction in sodium intake demonstrated the efficacy of this nonpharmacological therapy. In addition, a positive relationship between urinary sodium (the most reliable estimate of salt intake) and left ventricular mass was found in normotensive and hypertensive cohorts independent of blood pressure. In recent years, cardiovascular morbidity has been positively correlated with increasing sodium intake, despite one contradictory study. The role of nonpressure- related effects of dietary sodium is discussed to bring additional and convincing arguments to support a large-scale attempt to reduce sodium intake by 30–50%.
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References
Law MR, Frost CD, Wald NJ (1991) By how much does dietary salt reduction lower blood pressure? I Analysis of observational data among populations. BMJ 302:811–815
Sacks FM, Svetkey LP, Vollmer WM et al DASH — Sodium Collaborative Research Group (2001) Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH — Sodium Collaborative Research Group. N Engl J Med 344:3–10
Hooper L, Bartlett C, Smith GD, Ebrahim S (2002) Systematic review of long-term effects of advice to reduce dietary salt in adults. BMJ 325:628–637
du Cailar G, Ribstein J, Daures JP, Mimran A (1992) Sodium and left ventricular mass in untreated hypertensive and normotensive subjects. Am J Physiol 263:H177–H181
Schmieder RE, Messerli FH, Garavaglia GE, Nunez BS (1988) Salt intake as a determinant of cardiac involvement in essential hypertension. Circulation 78:951–956
du Cailar G, Ribstein J, Mimran A. (2002) Dietary sodium and target organ damage in essential hypertension. Am J Hypertens 15:222–229
Hillege HL, Fidler V, Diercks GF et al Prevention of Renal and Vascular End Stage Disease (PREVEND) Study Group (2002) Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population. Circulation 106:1777–1782
Olsen MH, Wachtell K, Ibsen H et al LIFE Study Investigators (2006) Reductions in albuminuria and in electrocardiographic left ventricular hypertrophy independently improve prognosis in hypertension: the LIFE study. J Hypertens 24:775–781
Wang TJ, Evans JC, Meigs JB et al (2005) Low-grade albuminuria and the risks of hypertension and blood pressure progression. Circulation 111:1370–1376
Dhingra R, Pencina M, Benjamin E et al (2004) Cross-sectional relations of urinary sodium excretion to cardiac structure and hypertrophy. The Framingham Heart Study. Am J Hypertens 17:891–896
Safar ME (2000) Pulse pressure, arterial stiffness, and cardiovascular risk. Curr Opin Cardiol 15:258–263
Morito A, Uzu T, Fujii T et al (1997) Sodium sensitivity and cardiovascular events in patients with essential hypertension. Lancet 350:1734–1737
Weinberger MH, Fineberg NS, Fineberg SE, Weinberger M (2001) Salt sensitivity, pulse pressure, and death in normal and hypertensive humans. Hypertension 37(Part 2):429–432
Alderman MH, Madhavan S, Cohen H et al (1995) Low urinary sodium is associated with greater risk of myocardial infarction among treated hypertensive men. Hypertension 25:1144–1152
He J, Ogden LG, Vupputuri S et al (1999) Dietary sodium intake and subsequent risk of cardiovascular disease in overweight adults. JAMA 282:2027–2034
Tuomilehto J, Jousilahti P, Rastenyte D et al (2001) Urinary sodium excretion and cardiovascular mortality in Finland: a prospective study. Lancet 357:848–851
Strazzullo P, D’Elia L, Kandala NB, Cappuccio FP (2009) Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies. BMJ 339:b4567
Jula AM, Karanko KM (1994) Effects on left ventricular hypertrophy of long-term nonpharmacological treatment with sodium restriction in mild-to-moderate essential hypertension. Circulation 89:1023–1031
Gates PE, Tanaka H, Hiatt WR, Seals DR (2004) Dietary sodium restriction rapidly improves large elastic artery compliance in older adults with systolic hypertension. Hypertension 44:35–41
Appel LJ, Espeland MA, Easter L et al (2001) Effects of reduced sodium intake on hypertension control in older individuals: results from the Trial of Nonpharmacologic Interventions in the Elderly (TONE). Arch Intern Med 161:685–693
Rugale C, Delbosc S, Cristol JP et al (2003) Sodium restriction prevents cardiac hypertrophy and oxidative stress in ANG II hypertension. Am J Physiol Heart 284:H1744–H1750
Takeda Y, Yoneda T, Demura M et al (2000) Sodium-induced cardiac aldosterone synthesis causes cardiac hypertrophy. Endocrinology 141:1901–1904
Cordaillat M, Rugale C, Casellas D et al (2005) Cardiorenal abnormalities associated with high sodium intake: correction by spironolactone in rats. Am J Physiol 289:R1137–R1143
Yu HCM, Burrell LM, Black MJ et al (1998) Salt induces myocardial and renal fibrosis in normotensive and hypertensive rats. Circulation 98:2621–2628
Lax DS, Benstein JA, Tolbert E, Dworkin LD (1990) Superiority of salt restriction over diuretics in reducing renal hypertrophy and injury in uninephrectomized SHR. Am J Physiol 258:F1675–F1681
Allen TJ, Waldron MJ, Casley D et al (1997) Salt restriction reduces hyperfiltration, renal enlargement, and albuminuria in experimental diabetes. Diabetes 46:19–24
He FJ, Markandu ND, Sagnella GA et al (2005) Plasma sodium: ignored and underestimated. Hypertension 45:98–102
Gu JW, Anand V, Shek EW et al (1998) Sodium induces hypertrophy of cultured myocardial myoblasts and vascular smooth muscle cells. Hypertension 31:1083–1087
Oberleithner H, Callies C, Kusche-Vihrog K et al (2009) Potassium softens vascular endothelium and increases nitric oxide release. Proc Natl Acad Sci U S A 106:2829–2834
Nickenig G, Strehlow K, Roeling J et al (1998) Salt induces vascular AT1 receptor overexpression in vitro and in vivo. Hypertension 31:1272–1277
Leenen FHH, Yuan B (1998) Dietary-sodium-induced cardiac remodeling in spontaneously hypertensive rats versus Wistar-Kyoto rat. J Hypertens 16:885–892
Kreutz R, Fernandez-Alfonso MS, Liu Y et al (1995) Induction of cardiac angiotensin I-converting enzyme with dietary NaCl-loading in genetically hypertensive and normotensive rats. J Mol Med 73:243–248
Gonzalez M, Lobos L, Castillo F et al (2005) High-salt diet inhibits expression of angiotensin type 2 receptor in resistance arteries. Hypertension 45:853–859
Brilla CG, Weber KT (1992) Mineralocorticoid excess, dietary sodium, and myocardial fibrosis. J Lab Clin Med 120:893–901
Pimenta E, Gaddam KK, Pratt-Ubunama MN et al (2008) Relation of dietary salt and aldosterone to urinary protein excretion in subjects with resistant hypertension. Hypertension 51:339–344
Laffer CL, Bolterman RJ, Romero JC, Elijovich F (2006) Effect of Salt on Isoprostanes in Salt-Sensitive Essential Hypertension. Hypertension 47:434–440
Fang Y, Mu JJ, He LC et al (2006) Salt loading on plasma asymmetrical dimethylarginine and the protective role of potassium supplement in normotensive salt-sensitive Asians. Hypertension 48:724–729
Williams JM, Pollock JS, Pollock DM (2004) Arterial pressure response to the antioxidant Tempol and ETB receptor blockade in rats on a high-salt diet. Hypertension 44:770–775
Yu L, Noble NA, Border WA (2002) Therapeutic strategies to halt renal fibrosis. Curr Opin Pharmacol 2:177–181
Ying WZ, Sanders PW (1998) Dietary salt enhances glomerular endothelial nitric oxide synthase through TGF-beta-1. Am J Physiol 275:F18–F24
Bibbins-Domingo K, Chertow GM, Coxson PG et al (2010) Projected effect of dietary salt reductions on future cardiovascular disease. N Engl J Med 20:1–10
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Mimran, A. (2010). Non-Pressure-Related Deleterious Effects of Excessive Dietary Sodium. In: Berbari, A.E., Mancia, G. (eds) Cardiorenal Syndrome. Springer, Milano. https://doi.org/10.1007/978-88-470-1463-3_3
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DOI: https://doi.org/10.1007/978-88-470-1463-3_3
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-1462-6
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