Abstract
Renalase, a novel, secreted flavin-adenine-dinucleotidedependent amine oxidase regulates cardiac function and blood pressure. The enzyme is rapidly activated in plasma by either modest increases in blood pressure or catecholamines. Protein expression in kidney and heart and its activation in plasma are markedly reduced in chronic kidney disease. The renalase knockout mouse is mildly hypertensive and more likely to develop severe ischemic renal and cardiac injury. Administration of recombinant renalase protects against myocardial injury and improves cardiac function. Preliminary data suggest that renalase may serve as an early biomarker for acute kidney injury. Single nucleotide polymorphisms of the renalase gene are reported to be associated with essential hypertension and more severe cardiovascular complications. The molecular mechanisms that underlie renalase’s action and its therapeutic utility are being examined.
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Desir, G.V. (2010). Role of Novel Biomarkers in Chronic Kidney Disease: Renalase. In: Berbari, A.E., Mancia, G. (eds) Cardiorenal Syndrome. Springer, Milano. https://doi.org/10.1007/978-88-470-1463-3_24
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DOI: https://doi.org/10.1007/978-88-470-1463-3_24
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-1462-6
Online ISBN: 978-88-470-1463-3
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