Skip to main content

Intra-Abdominal Infections: Diagnostic and Surgical Strategies

  • Chapter

Abstract

Intra-abdominal infections (IAIs) are defined as an inflammatory response of the peritoneum to micro-organisms and their toxins, which results in purulent exudate in the abdominal cavity [15]. They have two major manifestations: generalized peritonitis and IA abscess. Peritonitis remains a potentially fatal disease and still represents a challenge for surgeons [3]. Although greater understanding of the pathophysiology of IAIs, improvement in critical care, and timely surgical and/or radiological intervention have reduced the mortality associated with severe peritonitis, the rate remains unacceptably high, ranging from 3% in localized abscess to 10% in localized peritonitis, 32% in diffuse suppurative peritonitis, and 70–80% in complicated mixed infections [15]. In an effort to improve the results of treatment of severe IAIs, especially of those resulting from anastomotic leakage or perforation of the gastrointestinal tract (GIT), new surgical techniques have been introduced.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bosscha K, van Vroonhoven JMV, van der Werken C (1999) Surgical management of severe secondary peritonitis. Br J Surg 86:1371–1377

    Article  CAS  PubMed  Google Scholar 

  2. Sganga G, Brisinda G, Castagneto M (2001) Peritonitis: Priorities and management strategies. In: van Saene HKF, Sganga G, Silvestri L (eds) Infection in the critically ill: An ongoing challenge. Springer-Verlag, Berlin Heidelberg New York, pp 23–33

    Google Scholar 

  3. Sganga G (2000) Sepsi addominali chirurgiche e insufficienza multiorgano (MOFS). Edizioni Systems Comunicazioni, Milan

    Google Scholar 

  4. Bone RG, Balk RA, Cerra FB et al (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101:1644–1655

    Article  CAS  PubMed  Google Scholar 

  5. Pieracci FM, Barie PS (2007) Intra-abdominal infections. Curr Opin Crit Care 13:440–449

    Article  PubMed  Google Scholar 

  6. Solomkin JS, Mazuski JE, Baron EJ et al (2003) Guidelines for the selection of anti-infective agents for complicated intra-abdominal infections. Clin Infect Dis 37:997–1005

    Article  PubMed  Google Scholar 

  7. Brook I (2008) Microbiology and management of abdominal infections. Dig Dis Sci 53:2585–2591

    Article  PubMed  Google Scholar 

  8. Krepel CJ, Gohr CM, Edmiston CE, Condon RE (1995) Surgical sepsis: Constancy of antibiotic susceptibility of causative organisms. Surgery 117:505–509

    Article  CAS  PubMed  Google Scholar 

  9. Sganga G, Brisinda G, Castagneto M (2000) Nosocomial fungal infections in surgical patients: Risk factors and treatment. Minerva Anestesiol 66(Suppl 1):71–77

    Google Scholar 

  10. Wheeler AP, Bernard GR (1999) Treating patients with severe sepsis. N Engl J Med 340:207–214

    Article  CAS  PubMed  Google Scholar 

  11. Mannick JA, Rodrick ML, Lederer JA (2001) The immunologic response to injury. J Am Coll Surg 193:237–244

    Article  CAS  PubMed  Google Scholar 

  12. Knoferl MW, Angele MK, Diodato MD et al (2002) Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsis. Ann Surg 235:105–112

    Article  PubMed  Google Scholar 

  13. Sganga G, van Saene HKF, Brisinda G, Castagneto M (2001) Bacterial translocation. In: van Saene HKF, Sganga G, Silvestri L (eds) Infection in the critically ill: An ongoing challenge. Springer-Verlag, Berlin Heidelberg New York, pp 35–45

    Google Scholar 

  14. Gregor P, Prodger JD (1988) Mead Johnson Critical Care Symposium for the Practicing Surgeon. 4. Abdominal crisis in the intensive care unit. Can J Surg 31:331–332

    CAS  PubMed  Google Scholar 

  15. Gajic O, Errutia LE, Sewan H et al (2002) Acute abdomen in the medical intensive care unit. Crit Care Med 30:1187–1190

    Article  PubMed  Google Scholar 

  16. Kollef MH, Allen BT (1994) Determinants of outcome for patients in the medical intensive care unit requiring abdominal surgery: A prospective, single-center study. Chest 106:1822–1828

    Article  CAS  PubMed  Google Scholar 

  17. Velmahos GC, Kamel E, Berne TV et al (1999) Abdominal computed tomography for the diagnosis of intra-abdominal sepsis in critically injured patients: Fishing in murky waters. Arch Surg 134:831–836

    Article  CAS  PubMed  Google Scholar 

  18. Mokart D, Merlin M, Sannini A et al (2005) Procalcitonin, interleukin 6 and systemic inflammatory response syndrome (SIRS): Early markers of postoperative sepsis after major surgery. Br J Anaesthesiol 94:767–773

    Article  CAS  Google Scholar 

  19. Wickel DJ, Cheadle WG, Mercer-Jones MA, Garrison RN (1997) Poor outcome from peritonitis is caused by disease acuity and organ failure, not recurrent peritoneal infection. Ann Surg 225:744–756

    Article  CAS  PubMed  Google Scholar 

  20. Anbidge AE, Lynch D, Wison SR (2003) US of the peritoneum. Radiographics 23:663–684

    Article  Google Scholar 

  21. Go HL, Baarslag HJ, Vermeulen H et al (2005) A comparative study to validate the use of ultrasonography and computed tomography in patients with post-operative intra-abdominal sepsis. Eur J Radiol 54:383–387

    Article  CAS  PubMed  Google Scholar 

  22. Lin WY, Chao TH, Wang SJ (2002) Clinical features and gallium scan in the detection of postsurgical infection in the elderly. Eur J Nucl Med 29:371–375

    Article  Google Scholar 

  23. Shih-Chuan T, Te-Hsin C, Lin WY, Shyh-Jen W (2001) Abdominal abscesses in patients having surgery an application of Ga-67 scintigraphic and computed tomographic scanning. Clin Nucl Med 26:761–776

    Article  Google Scholar 

  24. Noone TC, Semelka RC, Wora Wattanakul S, Marcos H (1998) Intraperitoneal abscesses: Diagnostic accuracy of and appearances at MR imaging. Radiology 208:525–528

    CAS  PubMed  Google Scholar 

  25. Marshall J, Maier RV, Jimenez M, Dellinger EP (2004) Source control in the management of severe sepsis and septic shock: An evidence-based review. Crit Care Med 32(11 Suppl):S513–S526

    Article  PubMed  Google Scholar 

  26. Soares-Weiser K, Paul M, Brezis M, Leibovici L (2002) Antibiotic treatment for spontaneous bacterial peritonitis. BMJ 324:100–102

    Article  CAS  PubMed  Google Scholar 

  27. Solomkin JS, Wilson SE, Christou NV et al (2001) Results of a clinical trial of clinafloxacin versus imipenem/cilastatin for intraabdominal infections. Ann Surg 233:79–87

    Article  CAS  PubMed  Google Scholar 

  28. Mazuski JE (2007) Antimicrobial treatment for intra-abdominal infections. Expert Opin Pharmacother 8(17):2933–2945

    Article  CAS  PubMed  Google Scholar 

  29. Laterre PF (2008) Progress in medical management of intra-abdominal infection. Curr Opin Infect Dis 21(4):393–398

    Article  PubMed  Google Scholar 

  30. Cohen J (2000) Combination antibiotic therapy for severe peritonitis. Lancet 356:1539–1540

    Article  CAS  PubMed  Google Scholar 

  31. Holzheimer RG, Dralle H (2001) Paradigm change in 30 years peritonitis treatment. A review on source control. Eur J Med Res 6:161–168

    CAS  PubMed  Google Scholar 

  32. Schein M, Marshall J (2004) Source control for surgical infections. World J Surg 28(7):638–645

    Article  PubMed  Google Scholar 

  33. Rivers E, Nguyen B, Havstad S et al (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368–1377

    Article  CAS  PubMed  Google Scholar 

  34. Platell C, Papadimitriou JM, Hall JC (2000) The influence of lavage on peritonitis. J Am Coll Surg 191:672–680

    Article  CAS  PubMed  Google Scholar 

  35. Sganga G, Brisinda G, Castagneto M (2002) Trauma operative procedures: Timing of surgery and priorities. In: Gullo A (ed) Critical care medicine. Springer-Verlag, Berlin Heidelberg New York, pp 447–467

    Google Scholar 

  36. Levison MA, Zeigler D (1991) Correlation of APACHE II score, drainage technique and outcome in postoperative intra-abdominal abscess. Surg Gynecol Obstet 172:89–94

    CAS  PubMed  Google Scholar 

  37. Baril NB, Ralls PW, Wren SM et al (2000) Does an infected peripancreatic fluid collection or abscess mandate operation? Ann Surg 231:361–367

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag Italia

About this chapter

Cite this chapter

Sganga, G., Cozza, V. (2009). Intra-Abdominal Infections: Diagnostic and Surgical Strategies. In: Gullo, A., Lumb, P.D., Besso, J., Williams, G.F. (eds) Intensive and Critical Care Medicine. Springer, Milano. https://doi.org/10.1007/978-88-470-1436-7_26

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-1436-7_26

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1435-0

  • Online ISBN: 978-88-470-1436-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics