Abstract
Intra-abdominal infections (IAIs) are defined as an inflammatory response of the peritoneum to micro-organisms and their toxins, which results in purulent exudate in the abdominal cavity [1–5]. They have two major manifestations: generalized peritonitis and IA abscess. Peritonitis remains a potentially fatal disease and still represents a challenge for surgeons [3]. Although greater understanding of the pathophysiology of IAIs, improvement in critical care, and timely surgical and/or radiological intervention have reduced the mortality associated with severe peritonitis, the rate remains unacceptably high, ranging from 3% in localized abscess to 10% in localized peritonitis, 32% in diffuse suppurative peritonitis, and 70–80% in complicated mixed infections [1–5]. In an effort to improve the results of treatment of severe IAIs, especially of those resulting from anastomotic leakage or perforation of the gastrointestinal tract (GIT), new surgical techniques have been introduced.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Bosscha K, van Vroonhoven JMV, van der Werken C (1999) Surgical management of severe secondary peritonitis. Br J Surg 86:1371–1377
Sganga G, Brisinda G, Castagneto M (2001) Peritonitis: Priorities and management strategies. In: van Saene HKF, Sganga G, Silvestri L (eds) Infection in the critically ill: An ongoing challenge. Springer-Verlag, Berlin Heidelberg New York, pp 23–33
Sganga G (2000) Sepsi addominali chirurgiche e insufficienza multiorgano (MOFS). Edizioni Systems Comunicazioni, Milan
Bone RG, Balk RA, Cerra FB et al (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101:1644–1655
Pieracci FM, Barie PS (2007) Intra-abdominal infections. Curr Opin Crit Care 13:440–449
Solomkin JS, Mazuski JE, Baron EJ et al (2003) Guidelines for the selection of anti-infective agents for complicated intra-abdominal infections. Clin Infect Dis 37:997–1005
Brook I (2008) Microbiology and management of abdominal infections. Dig Dis Sci 53:2585–2591
Krepel CJ, Gohr CM, Edmiston CE, Condon RE (1995) Surgical sepsis: Constancy of antibiotic susceptibility of causative organisms. Surgery 117:505–509
Sganga G, Brisinda G, Castagneto M (2000) Nosocomial fungal infections in surgical patients: Risk factors and treatment. Minerva Anestesiol 66(Suppl 1):71–77
Wheeler AP, Bernard GR (1999) Treating patients with severe sepsis. N Engl J Med 340:207–214
Mannick JA, Rodrick ML, Lederer JA (2001) The immunologic response to injury. J Am Coll Surg 193:237–244
Knoferl MW, Angele MK, Diodato MD et al (2002) Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsis. Ann Surg 235:105–112
Sganga G, van Saene HKF, Brisinda G, Castagneto M (2001) Bacterial translocation. In: van Saene HKF, Sganga G, Silvestri L (eds) Infection in the critically ill: An ongoing challenge. Springer-Verlag, Berlin Heidelberg New York, pp 35–45
Gregor P, Prodger JD (1988) Mead Johnson Critical Care Symposium for the Practicing Surgeon. 4. Abdominal crisis in the intensive care unit. Can J Surg 31:331–332
Gajic O, Errutia LE, Sewan H et al (2002) Acute abdomen in the medical intensive care unit. Crit Care Med 30:1187–1190
Kollef MH, Allen BT (1994) Determinants of outcome for patients in the medical intensive care unit requiring abdominal surgery: A prospective, single-center study. Chest 106:1822–1828
Velmahos GC, Kamel E, Berne TV et al (1999) Abdominal computed tomography for the diagnosis of intra-abdominal sepsis in critically injured patients: Fishing in murky waters. Arch Surg 134:831–836
Mokart D, Merlin M, Sannini A et al (2005) Procalcitonin, interleukin 6 and systemic inflammatory response syndrome (SIRS): Early markers of postoperative sepsis after major surgery. Br J Anaesthesiol 94:767–773
Wickel DJ, Cheadle WG, Mercer-Jones MA, Garrison RN (1997) Poor outcome from peritonitis is caused by disease acuity and organ failure, not recurrent peritoneal infection. Ann Surg 225:744–756
Anbidge AE, Lynch D, Wison SR (2003) US of the peritoneum. Radiographics 23:663–684
Go HL, Baarslag HJ, Vermeulen H et al (2005) A comparative study to validate the use of ultrasonography and computed tomography in patients with post-operative intra-abdominal sepsis. Eur J Radiol 54:383–387
Lin WY, Chao TH, Wang SJ (2002) Clinical features and gallium scan in the detection of postsurgical infection in the elderly. Eur J Nucl Med 29:371–375
Shih-Chuan T, Te-Hsin C, Lin WY, Shyh-Jen W (2001) Abdominal abscesses in patients having surgery an application of Ga-67 scintigraphic and computed tomographic scanning. Clin Nucl Med 26:761–776
Noone TC, Semelka RC, Wora Wattanakul S, Marcos H (1998) Intraperitoneal abscesses: Diagnostic accuracy of and appearances at MR imaging. Radiology 208:525–528
Marshall J, Maier RV, Jimenez M, Dellinger EP (2004) Source control in the management of severe sepsis and septic shock: An evidence-based review. Crit Care Med 32(11 Suppl):S513–S526
Soares-Weiser K, Paul M, Brezis M, Leibovici L (2002) Antibiotic treatment for spontaneous bacterial peritonitis. BMJ 324:100–102
Solomkin JS, Wilson SE, Christou NV et al (2001) Results of a clinical trial of clinafloxacin versus imipenem/cilastatin for intraabdominal infections. Ann Surg 233:79–87
Mazuski JE (2007) Antimicrobial treatment for intra-abdominal infections. Expert Opin Pharmacother 8(17):2933–2945
Laterre PF (2008) Progress in medical management of intra-abdominal infection. Curr Opin Infect Dis 21(4):393–398
Cohen J (2000) Combination antibiotic therapy for severe peritonitis. Lancet 356:1539–1540
Holzheimer RG, Dralle H (2001) Paradigm change in 30 years peritonitis treatment. A review on source control. Eur J Med Res 6:161–168
Schein M, Marshall J (2004) Source control for surgical infections. World J Surg 28(7):638–645
Rivers E, Nguyen B, Havstad S et al (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368–1377
Platell C, Papadimitriou JM, Hall JC (2000) The influence of lavage on peritonitis. J Am Coll Surg 191:672–680
Sganga G, Brisinda G, Castagneto M (2002) Trauma operative procedures: Timing of surgery and priorities. In: Gullo A (ed) Critical care medicine. Springer-Verlag, Berlin Heidelberg New York, pp 447–467
Levison MA, Zeigler D (1991) Correlation of APACHE II score, drainage technique and outcome in postoperative intra-abdominal abscess. Surg Gynecol Obstet 172:89–94
Baril NB, Ralls PW, Wren SM et al (2000) Does an infected peripancreatic fluid collection or abscess mandate operation? Ann Surg 231:361–367
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Italia
About this chapter
Cite this chapter
Sganga, G., Cozza, V. (2009). Intra-Abdominal Infections: Diagnostic and Surgical Strategies. In: Gullo, A., Lumb, P.D., Besso, J., Williams, G.F. (eds) Intensive and Critical Care Medicine. Springer, Milano. https://doi.org/10.1007/978-88-470-1436-7_26
Download citation
DOI: https://doi.org/10.1007/978-88-470-1436-7_26
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-1435-0
Online ISBN: 978-88-470-1436-7
eBook Packages: MedicineMedicine (R0)