Cytological Pattern Profiling of Tumors from Different Visceral Sites
The cytological findings in FNB samples from the large majority of primary and secondary tumors detected in visceral sites, as well as those of metastatic tumors appearing in lymph nodes or soft tissues, can be classified according to the principles of pattern analysis. In the given case, this approach first requires identifying the specific category that the constituent cells belong to and then, if possible, classifying the set of observed morphological changes according to distinctive cytological patterns. The description of cytological features should be reproducibly standardized. At least nine major cytomorphological cell types can be identified. These are listed in Table 5.1. Each category includes a variable number of possible distinctive patterns. Once the major pattern has been identified, the diagnostic possibilities are dramatically reduced. The next step is to reach a conclusive diagnosis by prudent deductive reasoning based on additional ancillary data and/or clinical findings. Although a definitive diagnosis is not always possible, the identification of a specific pattern is nonetheless of importance for further clinical management of the case.
KeywordsRenal Oncoc Ytoma Chromatin Texture Cellular Dissociation Ymph Node Drenal Cortex
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