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Abstract

Fine-needle biopsy (FNB) is the most effective and efficient diagnostic procedure to study thyroid nodular lesions [1, 2, 3, 4, 5, 6, 7, 8, 9]. It is inexpensive, rapidly performed, very well-tolerated by the patient in any context, and immediately repeatable. In experienced hands, FNB is highly reliable in the diagnosis of benign lesions and in the identification and typing of a significant number of malignant tumors. Since the predictive value of a negative diagnosis is very high, the patient can be confidently assured and followed up unless other clinical conditions or risk factors warrant a more aggressive approach. The positive predictive value of the procedure is similarly high and the most appropriate oncological therapy can be started immediately after a FNB diagnosis of malignancy. There are, however, a few cases in which the diagnosis remains inevitably indeterminate in terms of possible malignancy [2,10]. These fall into the diagnostic category “follicular proliferation” and account for about 10–30% of cases in most series [2,10,11, 12, 13, 14].

Keywords

Follicular Carcinoma Follicular Adenoma Nuclear Change Follicular Lesion Nuclear Groof 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Italia 2009

Authors and Affiliations

  • Giorgio Gherardi
    • 1
    • 2
  1. 1.Institute of Anatomic Pathology and CytopathologyFatebenefratelli HospitalMilanItaly
  2. 2.Postgraduate School of Anatomic PathologyUniversity of MilanItaly

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