Despite the alarming worldwide increase in the incidence of breast cancer in the last 30 years, especially in highly developed countries, we have witnessed a parallel decrease in mortality and a longer disease-free survival of breast-cancer patients, both of which can be ascribed to increasingly early diagnosis and the use of drugs that are highly effective in large subgroups of patients.


Breast Lesion Minor Criterion Lobular Neoplasia Ithelial Cell Cellular Dissociation 
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  1. 1.
    Silverstein MJ (2000) The Van Nuys Breast Center: the first free-standing multidisciplinary breast center. Surg Oncol Clin North Am 9:159–175.Google Scholar
  2. 2.
    Tubiana M, Koscielny S (1999) The rationale for early diagnosis of cancer-the example of breast cancer. Acta Oncol 38:295–303.CrossRefPubMedGoogle Scholar
  3. 3.
    Abner AL, Collins L, Peiro G et al (1998) Correlation of tumor size and axillary lymph node involvement with prognosis in patients with T1 breast carcinoma. Cancer 83:2502–2508.CrossRefPubMedGoogle Scholar
  4. 4.
    Zarbo RJ, Howanitz PJ, Bachner P (1991) Interinstitutional comparison of performance in breast fine-needle aspiration cytology. A Q-probe quality indicator study. Arch Pathol Lab Med 115:743–750.PubMedGoogle Scholar
  5. 5.
    Ciatto S, Bonardi R, Cariaggi MP (1995) Performance of fine-needle aspiration cytology of the breast-multicenter study of 23,063 aspirates in ten Italian laboratories. Tumori 81:13–17.PubMedGoogle Scholar
  6. 6.
    Arisio R, Cuccorese C, Accinelli G et al (1998) Role of fineneedle aspiration biopsy in breast lesions: analysis of a series of 4,110 cases. Diagn Cytopathol 18:462–467.CrossRefPubMedGoogle Scholar
  7. 7.
    Ingram DM, Sterrett GF, Sheiner HJ, Shilkin KB (1998) Fine-needle aspiration cytology in the management of breast disease. Med J Aust 2:170–173.Google Scholar
  8. 8.
    Patel JJ, Gartell PC, Smallwood J et al (1987) Fine needle aspiration cytology of breast masses: an evaluation of its accuracy and reasons for diagnostic failure. Ann R Coll Surg Engl 69:156–159.PubMedGoogle Scholar
  9. 9.
    Elston CW, Cotton RE, Davies CJ, Blamey RW (1978) A comparison of the use of the “Tru-Cut” needle and fine needle aspiration cytology in the pre-operative diagnosis of carcinoma of the breast. Histopathology 2:239–254.CrossRefPubMedGoogle Scholar
  10. 10.
    Ballo MS, Sneige N (1996) Can core needle biopsy replace fine-needle aspiration cytology in the diagnosis of palpable breast carcinoma. A comparative study of 124 women. Cancer 78:773–777.CrossRefPubMedGoogle Scholar
  11. 11.
    Sun W, Li A, Abreo F, Turbat-Herrera E, Grafton WD (2001) Comparison of fine-needle aspiration cytology and core biopsy for diagnosis of breast cancer. Diagn Cytopathol 24:421–425.CrossRefPubMedGoogle Scholar
  12. 12.
    Westenend PJ, Sever AR, Beekman-De Volder HJ, Liem SJ (2001) A comparison of aspiration cytology and core needle biopsy in the evaluation of breast lesions. Cancer 93:146–150.CrossRefPubMedGoogle Scholar
  13. 13.
    Houssami N, Ciatto S, Ellis I, Ambrogetti D (2007) Underestimation of malignancy of breast core-needle biopsy: concepts and precise overall and category-specific estimates. Cancer 109:487–495.CrossRefPubMedGoogle Scholar
  14. 14.
    Kumaroswamy V, Liston J, Shaaban AM (2008) Vacuum assisted stereotactic guided mammotome biopsies in the management of screen detected microcalcifications: experience of a large breast screening centre. J Clin Pathol 61:766–769.CrossRefPubMedGoogle Scholar
  15. 15.
    Kikuchi M, Tsunoda-Shimizu H, Kawasaki T et al (2007) Indications for stereotactically-guided vacuum-assisted breast biopsy for patients with category 3 microcalcifications. Breast Cancer 14:285–291.CrossRefPubMedGoogle Scholar
  16. 16.
    Cobb CJ, Raza AS Obituary (2005) Alas poor FNA of breast-we knew thee well!. Diagn Cytopathol 32:1–4.CrossRefPubMedGoogle Scholar
  17. 17.
    Levine T (2004) Breast cytology-is there still a role? Cytopathology 15:293–296.CrossRefPubMedGoogle Scholar
  18. 18.
    Dray M, Mayall F, Darlington A (2000) Improved fine needle aspiration (FNA) cytology results with a near patient diagnosis service for breast lesions. Cytopathology 11:32–37.CrossRefPubMedGoogle Scholar
  19. 19.
    Brown LA, Coghill SB (1992) Cost effectiveness of a fine needle aspiration clinic. Cytopathology 3:275–280.CrossRefPubMedGoogle Scholar
  20. 20.
    Masood S, Frykberg ER, McLellan GL et al (1991) Cytologic differentiation between proliferative and nonproliferative breast disease in mammographically guided fine-needle aspirates. Diagn Cytopathol 7:581–590.CrossRefPubMedGoogle Scholar
  21. 21.
    Sneige N, Staerkel GA, Caraway NP et al (1994) A plea for uniform terminology and reporting of breast fine needle aspirates. M.D. Anderson Cancer Center proposal. Acta Cytol 38:971–972.PubMedGoogle Scholar
  22. 22.
    Perry N, Broeders M, de Wolf C, Törnberg S (eds) (2001) Pathology in mammography screening-non-operative diagnosis. European Guidelines for Quality Assurance in Mammographic Screening, 3rd Ed. Luxembourg: European Commission, pp 162–172.Google Scholar
  23. 23.
    Wilson ARM, Asbury D, Cooke J et al (2001) Clinical Guidelines For Breast Cancer Screening Assessment. Sheffield, NHS Breast Screening Programme (NHSBSP Publication No 49).Google Scholar
  24. 24.
    Ellis IO, Humphreys S, Michell M et al (2001) Cytology Sub-group of the National Coordinating Group for Breast Screening Pathology. Guidelines for Non-operative Diagnostic Procedures and Reporting in Breast Cancer Screening. Sheffield, NHS Cancer Screening Programmes 2001 (NHSBSP Publication No 50).Google Scholar
  25. 25.
    Brancato B, Bonardi R, Crocetti E et al (2004) Clinical significance and optimal management of patients with an “atypia, probably benign” (C3) report at FNAC of the breast. Breast J 10:458–489.CrossRefPubMedGoogle Scholar
  26. 26.
    Zhao C, Raza A, Martin SE et al (2009) Breast fine-needle aspiration samples reported as “proliferative breast lesion”: clinical utility of the subcategory “proliferative breast lesion with atypia”. Cancer Cytopathol 117:137–147.CrossRefPubMedGoogle Scholar
  27. 27.
    Martelli G, Pilotti S, Coopmans de Yoldi G et al (1990). Diagnostic efficacy of physical examination, mammography, fine needle aspiration cytology (triple-test) in solid breast lumps: an analysis of 1708 consecutive cases Tumori 76:476–479.Google Scholar
  28. 28.
    Irwig L, Macaskill P, Houssami N (2002) Evidence relevant to the investigation of breast symptoms: the triple test. Breast 11:215–220.CrossRefPubMedGoogle Scholar
  29. 29.
    Rosai J (2004). Breast. In: Rosai and Ackerman’s Surgical Pathology. 9th Ed, Vol 2. Mosby, Edinburgh, pp. 1787–1838.Google Scholar
  30. 30.
    Foxcroft LM, Evans EB, Porter AJ (2007) Difficulties in the pre-operative diagnosis of phyllodes tumours of the breast: a study of 84 cases. Breast 16:27–37.CrossRefPubMedGoogle Scholar
  31. 31.
    Ibarra JA (2006) Papillary Lesions of the Breast. The Breast Journal 12:237–251.CrossRefPubMedGoogle Scholar
  32. 32.
    Dawson AE, Mulford DK(1994) Benign versus malignant papillary neoplasms of the breast. Diagnostic clues in fine needle aspiration cytology. Acta Cytol 38:23–28.PubMedGoogle Scholar
  33. 33.
    Tavassoli FA, Hoefler H. Rosai J et al (2003) Intraductal proliferative lesions. In: Tavassoli FA, Devilee P (eds) Pathology and Genetics of Tumours of the Breast and Female Genital Organs. World Health Organization Classification of Tumours. IARC Press, Lyon, pp 60–75.Google Scholar
  34. 34.
    Burstein HJ, Polyak K, Wong JS et al (2004) Ductal carcinoma in situ of the breast. N Engl J Med 350:1430–1441.CrossRefPubMedGoogle Scholar
  35. 35.
    Gherardi G, Marveggio C (1999) Cytologic score and DNA-image analysis in the classification of borderline breast lesions: a prospective study on 47 fine-needle aspirates. Diagn Cytopathol 20:212–218.CrossRefPubMedGoogle Scholar
  36. 36.
    Haji BE, Das DK, Al-Ayadhy B et al (2007) Fine-needle aspiration cytologic features of four special types of breast cancers: mucinous, medullary, apocrine, and papillary. Diagn Cytopathol 35:408–416.CrossRefPubMedGoogle Scholar
  37. 37.
    Cheng L, Lee WY, Chang TW (2004) Benign mucocelelike lesion of the breast: how to differentiate from mucinous carcinoma before surgery. Cytopathology 15:104–108.CrossRefPubMedGoogle Scholar
  38. 38.
    Carder PJ, Murphy CE, Liston JC (2004) Surgical excision is warranted following a core biopsy diagnosis of mucocoele-like lesion of the breast. Histopathology 45:148–154.CrossRefPubMedGoogle Scholar
  39. 39.
    de la Torre M, Lindholm K, Lindgren A (1994) Fine needle aspiration cytology of tubular breast carcinoma and radial scar. Acta Cytol 38:884–890.PubMedGoogle Scholar
  40. 40.
    Lamb J, McGoogan E (1994) Fine needle aspiration cytology of breast in invasive carcinoma of tubular type and in radial scar/complex sclerosing lesions. Cytopathology 5:17–26.CrossRefPubMedGoogle Scholar
  41. 41.
    Fadare O, Tavassoli FA (2008) Clinical and pathologic aspects of basal-like breast cancers. Nat Clin Pract Oncol 5:149–159.CrossRefPubMedGoogle Scholar
  42. 42.
    Chen L, Fan Y, Lang RG et al (2008) Breast carcinoma with micropapillary features: clinicopathologic study and longterm follow-up of 100 cases. Int J Surg Pathol 16:155–163.CrossRefPubMedGoogle Scholar
  43. 43.
    Lui PC, Lau PP, Tse GM et al (2007) Fine needle aspiration cytology of invasive micropapillary carcinoma of the breast. Pathology 39:401–405.CrossRefPubMedGoogle Scholar
  44. 44.
    Ng WK, Poon CS, Kong JH (2001) Fine needle aspiration cytology of invasive micropapillary carcinoma of the breast: review of cases in a three-year period. Acta Cytol 45:973–979.PubMedGoogle Scholar
  45. 45.
    Tanaka K, Imoto S, Wada N et al (2008). Invasive apocrine carcinoma of the breast: clinicopathologic features of 57 patients. Breast J 14:164–168.CrossRefPubMedGoogle Scholar
  46. 46.
    Soon SR, Yong WS, Ho GH et al (2008) Adenoid cystic breast carcinoma: a salivary gland-type tumour with excellent prognosis and implications for management. Pathology 40:413–415.CrossRefPubMedGoogle Scholar
  47. 47.
    Tse GM, Tan PH, Lui PC, Putti TC (2008) Spindle cell lesions of the breast-the pathologic differential diagnosis. Breast Cancer Res Treat 109:199–207.CrossRefPubMedGoogle Scholar
  48. 48.
    Malberger E, Yerushalmi R, Tamir A, Keren R (1997) Diagnosis of fibroadenoma in breast fine needle aspirates devoid of typical stroma. Acta Cytol 41:1483–1438.PubMedGoogle Scholar
  49. 49.
    Ventura K, Cangiarella J, Lee I et al (2003) Aspiration biopsy of mammary lesions with abundant extracellular mucinous material. Review of 43 cases with surgical follow-up. Am J Clin Pathol 120:194–202.CrossRefPubMedGoogle Scholar
  50. 50.
    Simsir A, Tsang P, Greenebaum E (1998) Additional mimics of mucinous mammary carcinoma: fibroepithelial lesions. Am J Clin Pathol 109:169–172.PubMedGoogle Scholar
  51. 51.
    Dusenbery D, Frable WJ (1992) Fine needle aspiration cytology of phyllodes tumor. Potential diagnostic pitfalls. Acta Cytol 36:215–221.PubMedGoogle Scholar
  52. 52.
    Simsir A, Waisman J, Thorner K, Cangiarella J (2003) Mammary lesions diagnosed as “papillary” by aspiration biopsy: 70 cases with follow-up. Cancer 99:156–165.CrossRefPubMedGoogle Scholar
  53. 53.
    Kobayashi TK, Ueda M, Nishino T et al (1992) Spontaneous infarction of an intraductal papilloma of the breast: cytological presentation on fine needle aspiration. Cytopathology 3:379–384.PubMedGoogle Scholar
  54. 54.
    Shihara A, Kobayashi TK (2006). Infarcted intraductal papilloma of the breast: cytologic features with stage of infarction. Diagn Cytopathol 34:373–376.CrossRefGoogle Scholar
  55. 55.
    Ng WK, Kong JH (2003) Significance of squamous cells in fine needle aspiration cytology of the breast. A review of cases in a seven-year period. Acta Cytol 47:27–35.PubMedGoogle Scholar
  56. 56.
    Wong NL, Wan SK (2000) Comparative cytology of mucocele-like lesion and mucinous carcinoma of the breast in fine needle aspiration. Acta Cytol 44:765–770.PubMedGoogle Scholar
  57. 57.
    Yeoh GP, Cheung PS, Chan KW (1999) Fine-needle aspiration cytology of mucocele-like tumors of the breast. Am J Surg Pathol 23:552–559.CrossRefPubMedGoogle Scholar
  58. 58.
    Guadagni M, Nazzari G (2008) Zuska’s disease. G Ital Dermatol Venereol 143:157–160.PubMedGoogle Scholar
  59. 59.
    Gherardi G, Rossi S, Perrone S, Scanni A (2005) Angiosarcoma after breast-conserving therapy: fine-needle aspiration biopsy, immunocytochemistry, and clinicopathologic correlates. Cancer 105:145–151.CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia 2009

Authors and Affiliations

  • Giorgio Gherardi
    • 1
    • 2
  1. 1.Institute of Anatomic Pathology and CytopathologyFatebenefratelli HospitalMilanItaly
  2. 2.Postgraduate School of Anatomic PathologyUniversity of MilanItaly

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