An interventional approach by the pathologist is essential for the success of fine-needle biopsy (FNB) [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14]. FNB is a reliable, inexpensive, minimally invasive diagnostic procedure that is immediately repeatable and very well-tolerated by the patient. However, its success depends totally upon the capacity of the physician performing the procedure to reach the target, collect a representative sample, and, finally, optimally exploit the cellular sample for proper ancillary investigations. In other words, FNB is extremely operator-dependent, which represents a great limitation that has thus far negatively impacted potential diffusion of the procedure in many clinical contexts. In addition, inadequate or poor-quality samples have prevented pathologists from developing sufficient experience in the interpretation of cytological findings, thereby further undermining the popularity of FNB.


Samp Ling Circular Monolayer 
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  1. 1.
    Ljung BM, Drejet A, Chiampi N et al (2001) Diagnostic accuracy of fine-needle aspiration biopsy is determined by physician training in sampling technique. Cancer 93: 263–268.CrossRefPubMedGoogle Scholar
  2. 2.
    Dray M, Mayall F, Darlington A (2000) Improved fine needle aspiration (FNA) cytology results with a near patient diagnosis service for breast lesions. Cytopathology 11:32–37.CrossRefPubMedGoogle Scholar
  3. 3.
    Mayall F, Denford A, Chang B, Darlington A (1998) Improved FNA cytology results with a near patient diagnosis service for non-breast lesions. J Clin Pathol 51:541–544.CrossRefPubMedGoogle Scholar
  4. 4.
    Florentine BD, Staymates B, Rabadi M et al (2006) Cancer Committee of the Henry Mayo Newhall Memorial Hospital. The reliability of fine-needle aspiration biopsy as the initial diagnostic procedure for palpable masses: a 4-year experience of 730 patients from a community hospital-based outpatient aspiration biopsy clinic. Cancer 107:406–416.CrossRefPubMedGoogle Scholar
  5. 5.
    Florentine BD, Staymates B, Rabadi M et al (2006) Cancer Committee of the Henry Mayo Newhall Memorial Hospital. Cost savings associated with the use of fine-needle aspiration biopsy (FNAB) for the diagnosis of palpable masses in a community hospital-based FNAB clinic. Cancer 107: 2270–2281.CrossRefPubMedGoogle Scholar
  6. 6.
    Anne S, Teot LA, Mandell DL (2008) Fine needle aspiration biopsy: role in diagnosis of pediatric head and neck masses. Int J Pediatr Otorhinolaryngol 72:1547–1553.CrossRefPubMedGoogle Scholar
  7. 7.
    Abele JS (2008) The case for pathologist ultrasound-guided fine-needle aspiration biopsy. Cancer 114:463–468.CrossRefPubMedGoogle Scholar
  8. 8.
    Brown LA, Coghill SB (1991) Fine needle aspiration cytology of the breast: factors affecting sensitivity. Cytopathology 2:67–74.CrossRefPubMedGoogle Scholar
  9. 9.
    Brown LA, Coghill SB, Powis SA (1991) Audit of diagnostic accuracy of FNA cytology specimens taken by the histopathologist in a symptomatic breast clinic. Cytopathology 2:1–6.CrossRefPubMedGoogle Scholar
  10. 10.
    Bandyopadhyay S, Pansare V, Feng J et al (2007) Frequency and rationale of fine needle aspiration biopsy conversion to core biopsy as a result of onsite evaluation. Acta Cytol 51:161–167.PubMedGoogle Scholar
  11. 11.
    Suen KC (2002). Fine-needle aspiration biopsy of the thyroid. Can Med Ass J 167:491–495.Google Scholar
  12. 12.
    Brown LA, Coghill SB (1992) Cost effectiveness of a fine needle aspiration clinic. Cytopathology 3:275–280.CrossRefPubMedGoogle Scholar
  13. 13.
    Kim A, Lee J, Choi JS et al (2000) Fine needle aspiration cytology of the breast. Experience at an outpatient breast clinic. Acta Cytol 44:361–367.PubMedGoogle Scholar
  14. 14.
    Padel AF, Coghill SB, Powis SJ (1993) Evidence that the sensitivity is increased and the inadequacy rate decreased when pathologists take aspirates for cytodiagnosis. Cytopathology 4:161–165.CrossRefPubMedGoogle Scholar
  15. 15.
    Stanley MW, Lowhagen T (1993) Fine needle aspiration of palpable masses. Butterworth-Heinemann, Boston.Google Scholar
  16. 16.
    Jeffrey PB, Miller TR (1996) Fine-needle aspiration cytology of the thyroid. In: Ljung BM (ed) Pathology: State of the art reviews. Hanley and Belfus, Philadelphia, p 320.Google Scholar
  17. 17.
    Koss LG, Woyke S, Olszewski W (1996) Aspiration biopsy. Cytologic interpretation and histologic bases. 2nd Ed. Igaku-Shoin, New York.Google Scholar
  18. 18.
    Bishop Pitman M, Abele J, Ali SZ et al (2008) Techniques for Thyroid FNA: A Synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference. Diagn Cytopathol 36:407–424.CrossRefGoogle Scholar
  19. 19.
    Zajdela A, de Maublanc MA, Schlienger P, Haye C (1986) Cytologic diagnosis of orbital and periorbital palpable tumors using fine-needle sampling without aspiration. Diagn Cytopathol 2:17–20.CrossRefPubMedGoogle Scholar
  20. 20.
    Cajulis RS, Sneige N (1993) Objective comparison of cellular yield in fine-needle biopsy of lymph nodes with and without aspiration. Diagn Cytopathol 9:43–45.CrossRefPubMedGoogle Scholar
  21. 21.
    Haddadi-Nezhad S, Larijani B, Tavangar SM, Nouraei SM (2003) Comparison of fine-needle-nonaspiration with fineneedle-aspiration technique in the cytologic studies of thyroid nodules. Endocr Pathol 14:369–373.CrossRefPubMedGoogle Scholar
  22. 22.
    Rizvi SA, Husain M, Khan S, Mohsin M (2005) A comparative study of fine needle aspiration cytology versus non-aspiration technique in thyroid lesions. Surgeon 3:273–276.CrossRefPubMedGoogle Scholar
  23. 23.
    Pothier DD, Narula AA (2006) Should we apply suction during fine needle cytology of thyroid lesions? A systematic review and metaanalysis. Ann R Coll Surg Engl 88:643–645.CrossRefPubMedGoogle Scholar
  24. 24.
    Matalon TAS, Silver B (1999) US guidance of interventional procedures. Radiology 174:43–47.Google Scholar
  25. 25.
    Caturelli E, Giacobbe A, Facciorusso D et al (1996) Freehand technique with ordinary antisepsis in abdominal US-guided fine-needle punctures: three-year experience. Radiology 199:721–723.PubMedGoogle Scholar
  26. 26.
    Abele JS, Miller TR, King EB, Lowhagen T (1985) Smearing techniques for the concentration of particles from fine needle aspiration biopsy. Diagn Cytopathol 1:59–65.CrossRefPubMedGoogle Scholar
  27. 27.
    Koss LG (1992) Diagnostic Cytology and its histopathologic bases. Cytologic Techniques. Lippincott, Philadelphia, pp 1503–1504.Google Scholar
  28. 28.
    Kaminsky DB (1981) Aspiration Biopsy for the Community Hospital. In: Johnston WW (ed) Masson Monographs in Diagnostic Cytopathology, Masson Publishing USA, New York, pp 12–13.Google Scholar
  29. 30.
    Ackerman AB (1978) Histologic Diagnosis of Inflammatory Skin Diseases. A Method by Pattern Analysis. Lea & Febiger, Philadelphia, pp 157–168.Google Scholar

Copyright information

© Springer-Verlag Italia 2009

Authors and Affiliations

  • Giorgio Gherardi
    • 1
    • 2
  1. 1.Institute of Anatomic Pathology and CytopathologyFatebenefratelli HospitalMilanItaly
  2. 2.Postgraduate School of Anatomic PathologyUniversity of MilanItaly

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