Neonatology pp 724-730 | Cite as

Necrotizing Enterocolitis

  • Elvira Parravicini
  • Federica Fromm


The very first time Necrotizing Enterocolitis (NEC) appeared in medical literature was 1952, when two articles published in Z. Kinderheikd described a particularly severe form of enteritis, which the authors called Enterocolitis Ulcerosa Necroticans. Schmid described the pathology [1] and Quaiser the clinical aspect [2] of the diseases. The year after, the same authors named this condition Necrotizing Enterocolitis (NEC) [3]. It was only in 1964 that Berdon from the New York Babies Hospital described the clinical and radiological findings of the disease [4]. Since the first description of NEC, multiple etiologic factors have been identified, however many questions related to pathogenesis, early diagnosis, treatment and prevention, remain unanswered.


Premature Infant Enteral Feeding Bifidobacterium Infantis Enterobacter Sakazakii Abnormal Inflammatory Response 


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Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Elvira Parravicini
    • 1
  • Federica Fromm
  1. 1.Department of Pediatrics, Division of Neonatology, Morgan Stanley Children’s Hospital of New York-PresbyterianColumbia University Medical CenterNew YorkUSA

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