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Neonatology pp 650–658Cite as

Neonatal Cholestasis-Conjugated Hyperbilirubinemia

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Abstract

Jaundice during the first few weeks of life is a common finding. Frequently, such jaundice is due to elevation of the unconjugated, or indirect bilirubin, and is often the result of a benign process. More concerning is jaundice due to elevation of the conjugated bilirubin fraction. Neonatal cholestasis is defined as an accumulation of biliary substances, such as bilirubin and bile acids because of impaired canalicular bile flow. Neonatal cholestasis manifests with a conjugated hyperbilirubinemia and must be differentiated from unconjugated hyperbilirubinemia, as it is more often associated with a specific disease process. The incidence of neonatal cholestasis has been estimated at 1 in 2500 live births [1].

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Authors and Affiliations

  1. Department of Pediatrics, Division of Pediatric Gastroenterology, University of Minnesota, Minneapolis, Minnesota, USA

    Glenn R. Gourley

Authors
  1. Chad M. Best
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  2. Glenn R. Gourley
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  3. Vinod K. Bhutani
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Editor information

Editors and Affiliations

  1. Department of Pediatrics, Obstetrics and Reproductive Medicine, Division of Neonatology, University of Siena General Hospital S. Maria alle Scotte Azienda Ospedaliera Universitaria Senese, Siena, Italy

    Giuseppe Buonocore (Professor of Pediatrics and Neonatology, Head of School of Pediatrics) (Professor of Pediatrics and Neonatology, Head of School of Pediatrics)

  2. University of Siena, Siena, Italy

    Rodolfo Bracci (Formerly Professor of Pediatrics and Head of Department of Pediatrics, Obstetrics and Reproductive Medicine) (Formerly Professor of Pediatrics and Head of Department of Pediatrics, Obstetrics and Reproductive Medicine)

  3. University of Liverpool, UK

    Michael Weindling (Professor of Perinatal Medicine, Director of Postgraduate Research, Head of School of Paediatrics Mersey Deanery) (Professor of Perinatal Medicine, Director of Postgraduate Research, Head of School of Paediatrics Mersey Deanery)

  4. Department of Women’s and Children’s Health, Institute of Translational Medicine, Liverpool, UK

    Michael Weindling (Professor of Perinatal Medicine, Director of Postgraduate Research, Head of School of Paediatrics Mersey Deanery) (Professor of Perinatal Medicine, Director of Postgraduate Research, Head of School of Paediatrics Mersey Deanery)

  5. Liverpool Women’s Hospital, Liverpool, UK

    Michael Weindling (Professor of Perinatal Medicine, Director of Postgraduate Research, Head of School of Paediatrics Mersey Deanery) (Professor of Perinatal Medicine, Director of Postgraduate Research, Head of School of Paediatrics Mersey Deanery)

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© 2012 Springer-Verlag Italia

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Best, C.M., Gourley, G.R., Bhutani, V.K. (2012). Neonatal Cholestasis-Conjugated Hyperbilirubinemia. In: Buonocore, G., Bracci, R., Weindling, M. (eds) Neonatology. Springer, Milano. https://doi.org/10.1007/978-88-470-1405-3_86

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  • DOI: https://doi.org/10.1007/978-88-470-1405-3_86

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1404-6

  • Online ISBN: 978-88-470-1405-3

  • eBook Packages: MedicineMedicine (R0)

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