Neonatology pp 641-649 | Cite as

Pathology and Treatment of Liver Diseases

  • Giuseppe Maggiore
  • Silvia Riva


Liver disease in the newborn usually presents with two principal and distinct syndromes: neonatal cholestasis and neonatal liver failure.


Bile Acid Biliary Atresia Acute Liver Failure Bile Acid Synthesis Serum Bile Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Chardot C (2006) Biliary atresia. Orphanet J Rare Dis 26: 1–28Google Scholar
  2. 2.
    Serinet MO, Wildhaber BE, Broué P et al (2009) Impact of age at Kasai operation on its results in late childhood and adolescence: a rational basis for biliary atresia screening. Pediatrics 123: 1280–1286PubMedCrossRefGoogle Scholar
  3. 3.
    Hsiao CH, Chang MH, Chen HL et al (2008) Universal screening for biliary atresia using an infant stool color card in Taiwan. Hepatology 47: 1233–1240PubMedCrossRefGoogle Scholar
  4. 4.
    Davit-Spraul A, Gonzales E, Baussan C, Jacquemin E (2009) Progressive familial intrahepatic cholestasis. Orphanet J Rare Dis 8: 1CrossRefGoogle Scholar
  5. 5.
    Jacquemin E, Setchell KD, O’Connell NC et al (1994) A new cause of progressive intrahepatic cholestasis: 3 beta-hydroxy-C27-steroid dehydrogenase/isomerase deficiency. J Pediatr 125: 379–384PubMedCrossRefGoogle Scholar
  6. 6.
    Alagille D, Estrada A, Hadchouel M et al (1987) Syndromic paucity of interlobular bile ducts (Alagille syndrome or arteriohepatic dysplasia): review of 80 cases. J Pediatr 110: 195–200PubMedCrossRefGoogle Scholar
  7. 7.
    Primhak RA, Tanner MS (2001) Alpha-1-antitrypsin deficiency. Arch Dis Child 85: 2–5PubMedCrossRefGoogle Scholar
  8. 8.
    Bernard O (1998) Early diagnosis of neonatal cholestatic jaundice. Arch Pediatr 5: 1031–1035PubMedCrossRefGoogle Scholar
  9. 9.
    Maggiore G, Bernard O, Hadchouel M et al (1991) Diagnostic value of serum gamma-glutamyl transpeptidase activity in liver diseases in children. J Pediatr Gastroenterol Nutr 12: 21–26PubMedCrossRefGoogle Scholar
  10. 10.
    Moyer V, Freese DK, Whitington PF et al (2004) North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Guideline for the evaluation of cholestatic jaundice in infants: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 39: 115–128Google Scholar
  11. 11.
    Bucuvalas J, Yazigi N, Squires RH Jr (2006) Acute liver failure in children. Clin Liv Dis 10: 149–168CrossRefGoogle Scholar
  12. 12.
    Dhawan A, Mieli Vergani G (2005) Acute liver failure in neonates. Early Hum Dev 81: 1005–1010PubMedCrossRefGoogle Scholar
  13. 13.
    Durand P, Debray D, Mandel R et al (2001) Acute liver failure in infancy: a 14-year experience of a pediatric liver transplantation center. J Pediatr 139: 871–876PubMedCrossRefGoogle Scholar
  14. 14.
    McClean P, Davison S (2003) Neonatal liver failure. Semin Neonatol 8: 393–401PubMedCrossRefGoogle Scholar
  15. 15.
    Whitington PF (2006) Fetal and infantile hemocromatosis. Hepatology 43: 654–660PubMedCrossRefGoogle Scholar
  16. 16.
    Clayton PT (2002) Inborn errors presenting with liver dysfunction. Semin Neonatol 7: 49–63PubMedCrossRefGoogle Scholar
  17. 17.
    Bergounioux J, Franchi-Abella S, Monneret S et al (2004) Neonatal ischemic liver failure: potential role of the ductus venosus. J Pediatr Gastroenterol Nutr 38: 542–544PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Giuseppe Maggiore
    • 1
    • 2
  • Silvia Riva
  1. 1.Department of Reproductive Medicine and Child Development, Division of PediatricsUniversity of PisaItaly
  2. 2.Santa Chiara University HospitalPisaItaly

Personalised recommendations