Abstract
During the past 15 years, intrauterine inflammation has been identified as an etiologic key factor of fetal and neonatal morbidity and mortality, as well as an adverse long-term outcome of very immature preterm infants. Various microorganisms residing in the maternal recto-vaginal tract may invade the chorioamniotic membranes and eventually induce an inflammatory response in the amniotic cavity, the fetus and the mother [1].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Romero R, Garite TJ (2008) Twenty percent of very preterm neonates (23–32 weeks of gestation) are born with bacteremia caused by genital Mycoplasmas. Am J Obstet Gynecol 198:1–3
Lahra MM, Jeffery HE (2004) A fetal response to chorioamnionitis is associated with early survival after preterm birth. Am J Obstet Gynecol 190:147–151
Onderdonk AB, Delaney ML, DuBois AM et al (2008) Detection of bacteria in placental tissues obtained from extremely low gestational age neonates. Am J Obstet Gynecol 198:110.e1–7
Speer CP (2009) Chorioamnionitis, postnatal factors and proinflammatory response in the pathogenetic sequence of bronchopulmonary dysplasia. Neonatology 95:353–361
Speer CP (2006) Role of inflammation in the evolution of bronchopulmonary dysplasia. Drug Discovery Today: Disease Mechanisms 3:409–414
Speer CP (2006) Inflammation and bronchopulmonary dysplasia: A continuing story. Semin Fetal Neonatal Med 11:354–362
Speer CP (2008) Role of inflammation in the pathogenesis of acute and chronic neonatal lung disease. In: Bancalari E (ed) The newborn lung: Questions and controversies in neonatology series. Pulmonary volume, 1st edn. Saunders WB, Philadelphia, pp 166–186
Kramer BW (2008) Antenatal inflammation and lung injury: Prenatal origin of neonatal disease. J Perinatol 28:S21–27
Kramer BW, Kramer S, Ikegami M, Jobe AH (2002) Injury, inflammation, and remodelling in fetal sheep lung after intra-amniotic endotoxin. Am J Physiol Lung Cell Mol Physiol 283:L452–459
Buhimschi CS, Dulay AT, Abdel-Razeq S et al (2009) Fetal inflammatory response in women with proteomic biomarkers characteristic of intra-amniotic inflammation and preterm birth. BJOG 116:257–267
Dammann O, O’Shea TM (2008) Cytokines and perinatal brain damage. Clin Perinatol 35:643–663
Malaeb S, Dammann O (2009) Fetal inflammatory response and brain injury in the preterm newborn. J Child Neurol 24:1119–1126
Goldenberg RL, Andrews WW, Goepfert AR et al (2008) The Alabama Preterm Birth Study: umbilical cord blood Ureaplasma urealyticum and Mycoplasma hominis cultures in very preterm newborn infants. Am J Obstet Gynecol 198:43.e1–5
Viscardi RM, Atamas SP, Luzina IG et al (2006) Antenatal Ureaplasma urealyticum respiratory tract infection stimulates proinflammatory, profibrotic responses in the preterm baboon lung. Pediatr Res 60:141–146
Paananen R, Husa AK, Vuolteenaho R et al (2009) Blood cytokines during the perinatal period in very preterm infants: Relationship of inflammatory response and bronchopulmonary dysplsia. J Pediatr 154:39–43
Saugstad OD (2005) Oxidative stress in the newborn-a 30-year perspective. Biol Neonate 88:228–236
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Italia
About this chapter
Cite this chapter
Speer, C.P. (2012). Prenatal and Postnatal Inflammatory Mechanisms. In: Buonocore, G., Bracci, R., Weindling, M. (eds) Neonatology. Springer, Milano. https://doi.org/10.1007/978-88-470-1405-3_7
Download citation
DOI: https://doi.org/10.1007/978-88-470-1405-3_7
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-1404-6
Online ISBN: 978-88-470-1405-3
eBook Packages: MedicineMedicine (R0)