Neonatology pp 31-45 | Cite as

Congenital Malformations and Syndromes: Early Diagnosis and Prognosis

  • Giovanni Corsello
  • Mario Giuffrè


Congenital malformations are defects of the morphogenesis of organs or body regions identified during intrauterine development or at birth. They may be isolated and single, or multiple. Their global birth prevalence is about 2–3%. Congenital defects may be caused by genetic and/or environmental factors, acting singly or in combination. Diagnostic and therapeutic tools have allowed better identification of congenital malformations and have reduced long-term morbidity and mortality in affected patients. Because of increased life expectancy, congenital malformations today represent a major issue in health care because of the resources needed for multidisciplinary care.


Turner Syndrome Cleft Palate Noonan Syndrome Palpebral Fissure Frontal Boss 


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Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Giovanni Corsello
    • 1
  • Mario Giuffrè
  1. 1.Mother and Child DepartmentUniversity of PalermoPalermoItaly

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