Abstract
Developmental pharmacology and therapeutics is a broad field that includes the study of drugs during growth and development and the effect of these drugs on development itself. Development is a continuum that includes periods of conception, fetal stages and the neonatal and childhood phases of development. This chapter focuses on pharmacology and therapeutics in the newborn infant.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Clark RH, Bloom BT, Spitzer AR, Gerstmann DR (2006) Reported medication use in the neonatal intensive care unit: data from a large national data set. Pediatrics 117: 1979–1987
Conroy S, McIntyre JM, Choonara I (1999) Unlicensed and off-label drug use in neonates. Arch Dis Child Fetal Neonatal Ed 80: F142–F144
Aranda JV, Cohen S, Neims AH (1976) Drug utilization in a newborn intensive care unit. J Pediatr 89: 315–317
American Academy of Pediatrics, Committee on Drugs (2002) Uses of drugs not described in the package insert (off-label uses). Pediatrics 110: 181–183
t Jong GW, Vulto AG, de Hoog M et al (2000) Unapproved and offlabel use of drugs in a children’s hospital. N Engl J Med 343: 1125
Avenel S, Bomkratz A, Dassieu G et al (2000) The incidence of prescriptions without marketing product license in a neonatal intensive care unit. Arch Pediatr 7: 143–147
Guerrini R (2006) Valproate as a mainstay of therapy for paediatric epilepsy. Paediatr Drugs 8113–129
Heresi GP, Gerstmann DR, Reed MD et al (2006) The pharmaco- kinetics and safety of micafungin, a novel echinocandin, in premature infants. Pediatr Infect Dis J 25: 1110–1115
Hope WW, Mickiene D, Petraitis V et al (2008) The pharmacokinetics and pharmacodynamics of micafungin in experimental hematogenous Candida meningoencephalitis: implications for echinocandin therapy in neonates. J Infect Dis 197: 163–171
Benjamin DK Jr, Smith PB, Arrieta A (2010) Safety and pharma-cokinetics of repeat-dose micafungin in young infants. Clin Pharmacol Ther 87: 93–99
Taketomo CK, Hodding JH, Kraus DM (2008) Pediatric Dosage Handbook, 15th edn. Lexicomp, Hudson, Ohio, pp 1765–1768
Kearns GL, Abdel-Rahman SM, Alander SW et al (2003) Developmental pharmacology - drug disposition, action and therapy in infants and children. N Engl J Med 349: 1157–1167
Koren G (1997) Therapeutic drug monitoring principles in the neonate. Clin Chem 43: 222–227
Yaffe SJ, Aranda JV (2004) Neonatal and pediatric pharmacology, 3rd edn. Lippincott, Williams & Wilkins, Philadelphia
Rutter N (1996) The immature skin. Eur J Pediatr 155: S18–S20
Hoath SB, Narendran V (2000) Adhesives and emollients in the preterm infant. Semin Neonatol 5: 289–296
Campbell JM, Banta-Wright SA (2000) Neonatal skin disorders: a review of selected dermatologic abnormalities. J Perinatal Neonatal Nurs 14: 63–83
Shwayder T, Akland T (2006) Neonatal skin barrier: structure, function, and disorders. Dermatologic Ther 18: 87–103
Blake MJ, Castro L, Leeder JS, Kearns GL (2005) Ontogeny of drug metabolizing enzymes in the neonate. Semin Fetal Neonatal Med 10: 123–138
Pinto N, Halachmi N, Zulfikarali V et al (2005) Ontogeny of renal P-glycoprotein expression in mice: correlation with digoxin renal clearance. Pediatr Res 58: 1284–1289
Marquet P (1999) Therapeutic monitoring: analytic, pharmacokinetic and clinical aspects. Acta Clin Belg Supp 1: 1–12
Von Winckelmann SL, Spriet I, Willems L (2008) Therapeutic monitoring of phenytoin in critically ill patients. Pharmacotherapy 28: 1391–1400
Soldin OP, Soldin JP (2002) Review: Therapeutic drug monitoring in pediatrics. Ther Drug Monit 24: 1–8
Johannessen SI, Tomson I (2006) Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed? Clin Phar- macokinet 45: 1061–1075
Boreus LO (1989) The role of therapeutic drug monitoring in children. Clin Pharmacokinet 17 (Suppl 1): 4–12
Bartelink IH, Rademaker CM, Schobben AF, van den Anker JN (2006) Guidelines on paediatric dosing on the basis of develop-mental physiology and pharmacokinetic considerations. Clin Phar- macokinet 45: 1077–1097
Begg EJ, Barclay ML, Kirkpatrick CJ (1999) The therapeutic monitoring of antimicrobial agents. Br J Clin Pharmacol 47: 23–30
Nestas E, Bangstad HJ, Sandvik L, Wathane KO (2005) Amino- glycoside extended interval dosing in neonates is safe and effective: a meta-analysis. Arch Dis Child Fetal Neonatal Ed 90: F294–F300
de Hoog M, Mouton JW, Schoemaker RC et al (2002) Extended- interval dosing of tobramycin in neonates: Implications for therapeutic monitoring. Clin Pharmacol Ther 71: 349–358
Aust G (2001) Vestibulotoxicity and otoxicity of gentamicin in newborns at risk. Int Tinnitis J 7: 27–29
Moore RD, Lietman PS, Smith CR (1987) Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration. J Infectious Dis 155: 93–99
de Hoog M, Schoemaker RC, Mouton JW, van den Anker JN (1997) Tobramycin population pharmacokinetics in neonates. Clin Pharmacol Ther 62: 392–399
de Hoog M, Mouton JW, van den Anker JN (2004) Vancomycin: pharmacokinetics and administration regimens in neonates. Clin Pharmacokinet 43: 417–440
Grohskopf LA, Huskins WC, Sinkowitz-Cochran RL et al (2005) Use of antimicrobial agents in United States neonatal and pediatric intensive care patients. Pediatr Infect Dis J 24: 766–773
Bizzarro MJ Gallagher PG (2007) Antibiotic-resistant organisms in the neonatal intensive care unit. Semin Perinatol 31: 26–32
Capparelli EV, Lane JR, Romanowski GL et al (2001) The influences of renal function and maturation on vancomycin elimination in newborns and infants. J Clin Pharmacol 41: 927–934
Guilano C, Haase KK, Hall R (2010) Use of vanco PK-PD properties in the treatment of MRSA infections in newborns. Expert Rev Anti Ther 8: 95–106
Christensen ML, Helms RA, Chesney RW (1999) Is pediatric labeling really necessary? Pediatrics 104: 593–597
Hutchinson DJ, Liou Y, Best R, Zhao F (2010) Stability of extemporaneously prepared rufinamide oral suspensions. Ann Pharma- cother 44: 462–465
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Italia
About this chapter
Cite this chapter
Crane, E., Tutag Lehr, V., Mathew, M., Aranda, J.V. (2012). Developmental Pharmacology and Therapeutics. In: Buonocore, G., Bracci, R., Weindling, M. (eds) Neonatology. Springer, Milano. https://doi.org/10.1007/978-88-470-1405-3_52
Download citation
DOI: https://doi.org/10.1007/978-88-470-1405-3_52
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-1404-6
Online ISBN: 978-88-470-1405-3
eBook Packages: MedicineMedicine (R0)