Skip to main content

Developmental Pharmacology and Therapeutics

  • Chapter
Neonatology

Abstract

Developmental pharmacology and therapeutics is a broad field that includes the study of drugs during growth and development and the effect of these drugs on development itself. Development is a continuum that includes periods of conception, fetal stages and the neonatal and childhood phases of development. This chapter focuses on pharmacology and therapeutics in the newborn infant.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Clark RH, Bloom BT, Spitzer AR, Gerstmann DR (2006) Reported medication use in the neonatal intensive care unit: data from a large national data set. Pediatrics 117: 1979–1987

    Article  PubMed  Google Scholar 

  2. Conroy S, McIntyre JM, Choonara I (1999) Unlicensed and off-label drug use in neonates. Arch Dis Child Fetal Neonatal Ed 80: F142–F144

    Article  PubMed  CAS  Google Scholar 

  3. Aranda JV, Cohen S, Neims AH (1976) Drug utilization in a newborn intensive care unit. J Pediatr 89: 315–317

    Article  PubMed  CAS  Google Scholar 

  4. American Academy of Pediatrics, Committee on Drugs (2002) Uses of drugs not described in the package insert (off-label uses). Pediatrics 110: 181–183

    Article  Google Scholar 

  5. t Jong GW, Vulto AG, de Hoog M et al (2000) Unapproved and offlabel use of drugs in a children’s hospital. N Engl J Med 343: 1125

    Article  PubMed  Google Scholar 

  6. Avenel S, Bomkratz A, Dassieu G et al (2000) The incidence of prescriptions without marketing product license in a neonatal intensive care unit. Arch Pediatr 7: 143–147

    Article  PubMed  CAS  Google Scholar 

  7. Guerrini R (2006) Valproate as a mainstay of therapy for paediatric epilepsy. Paediatr Drugs 8113–129

    Google Scholar 

  8. Heresi GP, Gerstmann DR, Reed MD et al (2006) The pharmaco- kinetics and safety of micafungin, a novel echinocandin, in premature infants. Pediatr Infect Dis J 25: 1110–1115

    Article  PubMed  Google Scholar 

  9. Hope WW, Mickiene D, Petraitis V et al (2008) The pharmacokinetics and pharmacodynamics of micafungin in experimental hematogenous Candida meningoencephalitis: implications for echinocandin therapy in neonates. J Infect Dis 197: 163–171

    Article  PubMed  CAS  Google Scholar 

  10. Benjamin DK Jr, Smith PB, Arrieta A (2010) Safety and pharma-cokinetics of repeat-dose micafungin in young infants. Clin Pharmacol Ther 87: 93–99

    Article  PubMed  Google Scholar 

  11. Taketomo CK, Hodding JH, Kraus DM (2008) Pediatric Dosage Handbook, 15th edn. Lexicomp, Hudson, Ohio, pp 1765–1768

    Google Scholar 

  12. Kearns GL, Abdel-Rahman SM, Alander SW et al (2003) Developmental pharmacology - drug disposition, action and therapy in infants and children. N Engl J Med 349: 1157–1167

    Article  PubMed  CAS  Google Scholar 

  13. Koren G (1997) Therapeutic drug monitoring principles in the neonate. Clin Chem 43: 222–227

    PubMed  CAS  Google Scholar 

  14. Yaffe SJ, Aranda JV (2004) Neonatal and pediatric pharmacology, 3rd edn. Lippincott, Williams & Wilkins, Philadelphia

    Google Scholar 

  15. Rutter N (1996) The immature skin. Eur J Pediatr 155: S18–S20

    Article  PubMed  Google Scholar 

  16. Hoath SB, Narendran V (2000) Adhesives and emollients in the preterm infant. Semin Neonatol 5: 289–296

    Article  PubMed  CAS  Google Scholar 

  17. Campbell JM, Banta-Wright SA (2000) Neonatal skin disorders: a review of selected dermatologic abnormalities. J Perinatal Neonatal Nurs 14: 63–83

    CAS  Google Scholar 

  18. Shwayder T, Akland T (2006) Neonatal skin barrier: structure, function, and disorders. Dermatologic Ther 18: 87–103

    Article  Google Scholar 

  19. Blake MJ, Castro L, Leeder JS, Kearns GL (2005) Ontogeny of drug metabolizing enzymes in the neonate. Semin Fetal Neonatal Med 10: 123–138

    Article  PubMed  Google Scholar 

  20. Pinto N, Halachmi N, Zulfikarali V et al (2005) Ontogeny of renal P-glycoprotein expression in mice: correlation with digoxin renal clearance. Pediatr Res 58: 1284–1289

    Article  PubMed  CAS  Google Scholar 

  21. Marquet P (1999) Therapeutic monitoring: analytic, pharmacokinetic and clinical aspects. Acta Clin Belg Supp 1: 1–12

    Google Scholar 

  22. Von Winckelmann SL, Spriet I, Willems L (2008) Therapeutic monitoring of phenytoin in critically ill patients. Pharmacotherapy 28: 1391–1400

    Article  Google Scholar 

  23. Soldin OP, Soldin JP (2002) Review: Therapeutic drug monitoring in pediatrics. Ther Drug Monit 24: 1–8

    Google Scholar 

  24. Johannessen SI, Tomson I (2006) Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed? Clin Phar- macokinet 45: 1061–1075

    Article  CAS  Google Scholar 

  25. Boreus LO (1989) The role of therapeutic drug monitoring in children. Clin Pharmacokinet 17 (Suppl 1): 4–12

    Article  PubMed  Google Scholar 

  26. Bartelink IH, Rademaker CM, Schobben AF, van den Anker JN (2006) Guidelines on paediatric dosing on the basis of develop-mental physiology and pharmacokinetic considerations. Clin Phar- macokinet 45: 1077–1097

    Article  CAS  Google Scholar 

  27. Begg EJ, Barclay ML, Kirkpatrick CJ (1999) The therapeutic monitoring of antimicrobial agents. Br J Clin Pharmacol 47: 23–30

    Article  PubMed  CAS  Google Scholar 

  28. Nestas E, Bangstad HJ, Sandvik L, Wathane KO (2005) Amino- glycoside extended interval dosing in neonates is safe and effective: a meta-analysis. Arch Dis Child Fetal Neonatal Ed 90: F294–F300

    Article  Google Scholar 

  29. de Hoog M, Mouton JW, Schoemaker RC et al (2002) Extended- interval dosing of tobramycin in neonates: Implications for therapeutic monitoring. Clin Pharmacol Ther 71: 349–358

    Article  PubMed  Google Scholar 

  30. Aust G (2001) Vestibulotoxicity and otoxicity of gentamicin in newborns at risk. Int Tinnitis J 7: 27–29

    CAS  Google Scholar 

  31. Moore RD, Lietman PS, Smith CR (1987) Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration. J Infectious Dis 155: 93–99

    Article  CAS  Google Scholar 

  32. de Hoog M, Schoemaker RC, Mouton JW, van den Anker JN (1997) Tobramycin population pharmacokinetics in neonates. Clin Pharmacol Ther 62: 392–399

    Article  PubMed  Google Scholar 

  33. de Hoog M, Mouton JW, van den Anker JN (2004) Vancomycin: pharmacokinetics and administration regimens in neonates. Clin Pharmacokinet 43: 417–440

    Article  PubMed  Google Scholar 

  34. Grohskopf LA, Huskins WC, Sinkowitz-Cochran RL et al (2005) Use of antimicrobial agents in United States neonatal and pediatric intensive care patients. Pediatr Infect Dis J 24: 766–773

    Article  PubMed  Google Scholar 

  35. Bizzarro MJ Gallagher PG (2007) Antibiotic-resistant organisms in the neonatal intensive care unit. Semin Perinatol 31: 26–32

    Article  PubMed  Google Scholar 

  36. Capparelli EV, Lane JR, Romanowski GL et al (2001) The influences of renal function and maturation on vancomycin elimination in newborns and infants. J Clin Pharmacol 41: 927–934

    Article  PubMed  CAS  Google Scholar 

  37. Guilano C, Haase KK, Hall R (2010) Use of vanco PK-PD properties in the treatment of MRSA infections in newborns. Expert Rev Anti Ther 8: 95–106

    Article  Google Scholar 

  38. Christensen ML, Helms RA, Chesney RW (1999) Is pediatric labeling really necessary? Pediatrics 104: 593–597

    PubMed  CAS  Google Scholar 

  39. Hutchinson DJ, Liou Y, Best R, Zhao F (2010) Stability of extemporaneously prepared rufinamide oral suspensions. Ann Pharma- cother 44: 462–465

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Italia

About this chapter

Cite this chapter

Crane, E., Tutag Lehr, V., Mathew, M., Aranda, J.V. (2012). Developmental Pharmacology and Therapeutics. In: Buonocore, G., Bracci, R., Weindling, M. (eds) Neonatology. Springer, Milano. https://doi.org/10.1007/978-88-470-1405-3_52

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-1405-3_52

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1404-6

  • Online ISBN: 978-88-470-1405-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics