Neonatology pp 1199-1207 | Cite as

Neonatal Seizures

  • Malcolm Levene


Seizures are more common during the neonatal period than at any other time of life. This is because the neonatal brain is in a hyper-excitable state with an imbalance between the activities of neurotransmitters. During the early neonatal period, immature neurons express mainly GABA-nergic activity and paradoxically at this age GABA exerts a neuroexcitatory action. This appears to change in the early weeks of life when GABA receptors develop a more inhibitory effect [1]. As a result of this the neonatal brain is more likely to seize as a result of a variety of causes.


Status Epilepticus Seizure Activity Neonatal Brain Neonatal Seizure Clinical Seizure 
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Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Malcolm Levene
    • 1
    • 2
  1. 1.Academic Unit of Paediatrics and Child HealthUniversity of LeedsLeedsUK
  2. 2.Department of Neonatal MedicineLeeds Teaching Hospitals TrustLeedsUK

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