Neonatology pp 1147-1159 | Cite as

Biochemical Basis of Hypoxic-Ischemic Encephalopathy

  • Maria Delivoria-Papadopoulos
  • Endla Anday


Perinatal hypoxia ischemia is the most common cause of neurologic disease during the neonatal period. Hypoxic ischemic encephalopathy (HIE), is associated with a high mortality and morbidity rate, including cerebral palsy, mental retardation, and seizures [1]. The incidence of perinatal asphyxia is about 1.0–1.5% in most centers and is usually related to gestational age and birth weight. It occurs in 9.0% of infants less than 36 weeks’ gestation and in 0.5% of infants more than 36 weeks’ gestation [2, 3]. The etiology of perinatal HIE includes those circumstances that can affect the cerebral blood flow in the fetus and newborn compromising the supply of oxygen to the brain. They may develop antepartum (20%), intrapartum (30%), antepartum and intrapartum (35%), or postpartum (10%) [4].


NMDA Receptor Cerebral Palsy Hypoplastic Left Heart Syndrome Free Radical Generation Perinatal Asphyxia 
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Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Maria Delivoria-Papadopoulos
    • 1
  • Endla Anday
  1. 1.Department of Pediatrics, Drexel University College of MedicineSt. Christopher’s Hospital for ChildrenPhiladelphiaUSA

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