Neonatology pp 940-943 | Cite as

Neonatal Viral Infections: Enteroviruses, and Respiratory Syncytial Virus

  • Paolo Manzoni
  • Elisa Antonielli d’Oulx
  • Pier-Angelo Tovo


The detection and identification of viral infections in newborns has been greatly improved by the recent development of rapid and highly sensitive diagnostic methods, particularly polymerase chain reaction (PCR) techniques. Data from a retrospective analysis of neonates admitted to a Neonatal Intensive Care Unit (NICU) in the Netherlands during a 12 year period confirmed viral infection in about 1% of cases. Enterovirus or parechovirus (EV/PeV) were the most frequent causes (39% of cases), followed by respiratory syncytial virus (RSV) at 29% (Table 118.1). EVs caused the highest mortality rate and serious sequelae [1].


Respiratory Syncytial Virus Coxsackie Virus Severe Respiratory Syncytial Virus Respiratory Syncytial Virus Bronchiolitis Respiratory Syncytial Virus Disease 
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  1. 1.
    Verboon-Maciolek MA, Krediet TG, Gerards LJ et al (2005) Clinical and epidemiologic characteristics of viral infections in a neonatal intensive care unit during a 12-year period. Pediatr Infect Dis J 24: 901–904PubMedCrossRefGoogle Scholar
  2. 2.
    Verboon-Maciolek MA, Krediet TG, Gerards LJ et al (2008) Severe neonatal parechovirus infection and similarity with enterovirus infection. Pediatr Infect Dis J 27: 241–245PubMedCrossRefGoogle Scholar
  3. 3.
    Abzug MJ (2004) Presentation, diagnosis, and management of enterovirus infections in neonates. Paediatr Drugs 6: 1–10PubMedCrossRefGoogle Scholar
  4. 4.
    Cherry JD (2006) Enterovirus and Parechovirus Infections. In: Remington JS, Klein JO, Wilson CD et al (eds) Infectious diseases of the fetus and newborn infant. Saunders, Philadelphia, pp 783–822CrossRefGoogle Scholar
  5. 5.
    Verboon-Maciolek MA, Groenendaal F, Cowan F et al (2006) White matter damage in neonatal enterovirus meningoencephalitis. Neurology 66: 1267–1269PubMedCrossRefGoogle Scholar
  6. 6.
    Rasch G, Schreier E, Kiehl W et al (2001) Worldwide eradication of poliomyelitis. Wien Klin Wochenschr 113: 839–845PubMedGoogle Scholar
  7. 7.
    Fjaerli HO, Farstad T, Rød G et al (2005) Acute bronchiolitis in infancy as risk factor for wheezing and reduced pulmonary function by seven years in Akershus County, Norway. BMC Pediatr 5: 31Google Scholar
  8. 8.
    Guerguerian AM, Gauthier M, Lebel MH et al (1999) Ribavirin in ventilated respiratory syncytial virus bronchiolitis. A randomized, placebo-controlled trial. Am J Respir Crit Care Med 160: 829–834Google Scholar
  9. 9.
    Chávez-Bueno S, Mejías A, Merryman RA et al (2007) Intravenous palivizumab and ribavirin combination for respiratory syncytial virus disease in high-risk pediatric patients. Pediatr Infect Dis J 26: 1089–1093PubMedCrossRefGoogle Scholar
  10. 10.
    Simões EA, Carbonell-Estrany X, Fullarton JR et al (2008) A predictive model for respiratory syncytial virus (RSV) hospitalisation of premature infants born at 33-35 weeks of gestational age, based on data from the Spanish FLIP Study. Respir Res 9: 7810CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Paolo Manzoni
  • Elisa Antonielli d’Oulx
  • Pier-Angelo Tovo
    • 1
  1. 1.Department of PediatricsUniversity of TurinTurinItaly

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