In the developed world, human toxoplasmosis is considered a benign self-limiting disease mostly detectable by specific antibody Toxoplasma gondii-immunoglobulin (Tg-Ig) testing. Patent and sometimes devastating disease may be appreciated in immune-compromised hosts and congenitally infected infants . Congenital toxoplasmosis (CT) occurs almost exclusively when primary maternal infection occurs during gestation. As more than half of mothers giving birth to infected offspring could not recall an infection-related illness and no test reliably marks off infection time, there is pressure for screening. Alternative strategies include prenatal surveillance in Tg-Ig negative pregnant women and prophylaxis of fetal infection/damage in seroconverters, and newborn Tg-IgM testing on filter paper blood spots and sequelae prophylaxis in the Tg-IgM positive infant. Monthly or quarterly re-testing of unprotected pregnant women has been widely practised in the EU since the ’70s, whereas newborn testing has been included in the New England Neonatal Screening Program (NENSP) since 1986, and feasibility confirmed across the globe.
KeywordsMaternal Infection Tissue Cyst Congenital Toxoplasmosis Infected Infant Ocular Lesion
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