Neonatology pp 804-818 | Cite as

Physiology and Abnormalities of Leukocytes

  • Kurt R. Schibler


The circulating pool of neutrophils reflect a dynamic equilibrium between neutrophil precursors and mature neutrophils in the bone marrow, circulating neutrophils and activated neutrophils that have migrated into the tissues. The bone marrow is the predominant hematopoietic organ after birth. Within the bone marrow, pluripotential hematopoietic stem and progenitor cells give rise to lineage committed neutrophil precursors. These precursors mature under the influence of growth factors such as granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF). The bone marrow thus contains pools of immature neutrophils and of stored mature neutrophils. After leaving the bone marrow, neutrophils are transiently in the circulation for a brief period of hours after which they translocate into the tissues.


Hematopoietic Stem Cell Transplantation Chronic Granulomatous Disease Dyskeratosis Congenita Leukocyte Adhesion Deficiency Congenital Neutropenia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Kurt R. Schibler
    • 1
  1. 1.Department of Pediatrics, Division of NeonatologyCincinnati Children’s Hospital Medical CenterCincinnatiUSA

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