Neonatology pp 775-783 | Cite as

Coagulation Disorders: Clinical Aspects of Platelet Disorders

  • Antonio Del Vecchio


Platelets contribute to primary hemostasis and their function is affected by their number and condition. Platelets arise from the fragmentation of megakaryocytes in the bone marrow, and circulate in the blood as disk-shaped non-nucleated particles, with a lifespan of 7–10 days. Their average diameter is about 1.5 µm, 20% of the diameter of erythrocytes. Once released from the bone marrow, young platelets enter the circulation, where a large proportion pool in the spleen. It has been suggested that this splenic sequestration of young platelets is the result of a longer transit time of large platelets through the splenic cords. The spleen serves as a reservoir for platelets, containing about one-third, which are then able to enter the circulation after exercise or epinephrine administration. In addition to the spleen, the lungs also contain a small pool of platelets, perhaps 10–15% of the total number, and these are also able to enter the circulation after exercise or epinephrine administration [1].


Platelet Function Disseminate Intravascular Coagulation Congenital Adrenal Hyperplasia Platelet Transfusion Idiopathic Thrombocytopenic Purpura 
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Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Antonio Del Vecchio
    • 1
  1. 1.Division of Neonatology, Neonatal Intensive Care UnitDi Venere HospitalBariItaly

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