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Coagulation Disorders: Inflammation and Thrombosis

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Abstract

With a fifteen-fold increase in rate compared with infants and children, thrombosis is an important problem in the neonate. Most neonatal thromboses are diagnosed in the intensive care nursery in association with myriad underlying disorders, many of which are inflammatory. Clinically, most cases of neonatal thrombosis occur in two discrete populations: spontaneous perinatal events (primarily stroke and renal vein thrombosis) or catheter-related thrombosis related to neonatal intensive supportive care. The relationship of inflammation to these two categories of thrombosis is currently unknown.

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References

  1. Esmon CT (2005) The interactions between inflammation and coagulation. Brit J Haematol 131: 417–430

    Article  CAS  Google Scholar 

  2. Martorell L, Martínez-González J, Rodríguez C et al (2008) Thrombin and protease-activated receptors ( PARs) in atherothrombosis. Thromb Haemost 99: 305–315

    Google Scholar 

  3. Ridker PM, Cushman M, Stampfer MJ et al (1997) Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 336: 973–979

    Article  PubMed  CAS  Google Scholar 

  4. Fox EA, Kahn SR (2005) The relationship between inflammation and venous thrombosis. A systematic review of clinical studies. Thromb Haemost 94: 362–365

    Google Scholar 

  5. Redline RW (2006) Inflammatory responses in the placenta and umbilical cord. Semin Fetal Neonat Med 11: 296–301

    Article  Google Scholar 

  6. Redline RW (2005) Severe fetal placental vascular lesions in term infants with neurologic impairment. Am J Obstet Gynecol 192: 452–457

    Article  PubMed  Google Scholar 

  7. Ramaswarmy V, Horton J, Vandermeer B et al (2009) Systematic review of biomarkers of brain injury in term neonatal encephalopathy. Pediatr Neurol 40: 215–226

    Article  Google Scholar 

  8. Polydorides AD, Kalish RB, Witkin SS, Baergen RN (2007) A fetal cyclooxygenase-2 gene polymorphism is associated with placental malperfusion. Int J Gynecol Pathol 26: 284–290

    Article  PubMed  Google Scholar 

  9. Hausman N, Beharry K, Nishihara K et al (2003) Antenatal administration of celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, appears to improve placental perfusion in the pregnant rabbit. Prostaglandins Other Lipid Mediat 70: 303–315

    Article  PubMed  CAS  Google Scholar 

  10. Papafili A, Hill MR, Brull DJ et al (2002) Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response. Arterioscler Thromb Vasc Biol 22: 1631–1636

    Article  PubMed  CAS  Google Scholar 

  11. Cipollone F, Toniato E, Martinotti S et al (2004) A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke. JAMA 291: 2221–2228

    Article  PubMed  CAS  Google Scholar 

  12. Reddy S, Jia S, Geoffrey R (2009) An autoinflammatory disease due to homozygous deletion of the IL1RN locus. N Engl J Med 360: 2438–2444

    Article  PubMed  CAS  Google Scholar 

  13. Härtel C, König I, Köster S et al (2006) Genetic polymorphisms of hemostasis genes and primary outcome of very low birth weight infants. Pediatrics 118: 683–689

    Article  PubMed  Google Scholar 

  14. Lee J, Croen LA, Backstrand KH et al (2005) Maternal and infant characteristics associated with perinatal arterial stroke in the infant. JAMA 293: 723–729

    Article  PubMed  CAS  Google Scholar 

  15. Wu YW, Escobar GJ, Grether JK et al (2003) Chorioamnionitis and cerebral palsy in term and near-term infants. JAMA 290: 2677–2684

    Article  PubMed  CAS  Google Scholar 

  16. Golomb MR (2003) The contribution of prothrombotic disorders to peri- and neonatal ischemic stroke. Semin Thromb Hemost 29: 415–424

    Article  PubMed  Google Scholar 

  17. Armstrong-Wells J, Johnston SC, Wu YW (2009) Prevalence and Predictors of Perinatal Hemorrhagic Stroke. Pediatrics 123: 823–828

    Article  PubMed  Google Scholar 

  18. Wu YW (2002) Systematic review of chorioamnionitis and cerebral palsy. Ment Retard Dev Disabil Res Rev 8: 25–29

    Article  PubMed  Google Scholar 

  19. Nelson KB (2006) Thrombophilias, perinatal stroke, and cerebral palsy. Clin Obstet Gynecol 49: 875–884

    Article  PubMed  Google Scholar 

  20. Tincani A, Bazzani C, Zingarelli S, Lojacono A (2008) Lupus and the antiphospholipid antibody syndrome in pregnancy and obstetrics: clinical charcteristics, diagnosis, pathogenesis and treatment. Semin Thromb Hemost 34: 267–272

    Article  PubMed  CAS  Google Scholar 

  21. Ruffatti A, Tonello M, Cavazzana A et al (2009) Laboratory classification categories and pregnancy outcome in patients with primary antiphospholipid syndrome prescribed antithrombotic therapy. Thromb Res 123: 482–487

    Article  PubMed  CAS  Google Scholar 

  22. Silver RK, MacGregor SN, Pasternak JF, Neely SE (1992) Fetal stroke associated with elevated maternal anticardiolipin antibodies. Obstet Gynecol 80: 497–499

    PubMed  CAS  Google Scholar 

  23. Boffa MC, Lachassinne E (2007) Infant perinatal thrombosis and antiphospholipid antibodies: a review. Lupus 16: 634–641

    Article  PubMed  Google Scholar 

  24. Pober JS, Cotran RS (1990) Cytokines and endothelial cell biology. Physiol Rev 70: 427–451

    PubMed  CAS  Google Scholar 

  25. Wheeler RD, Boutin H, Touzani O et al (2003) No role for interleukin- 18 in acute murine stroke-induced brain injury. J Cereb Blood Flow Metab 23: 531–535

    Article  PubMed  CAS  Google Scholar 

  26. Wheeler RD, Brough D, LeFeuvre RA et al (2003) Interleukin-18 induces expression and release of cytokines from murine glial cells: interactions with interleukin-1 beta. J Neurochem 85: 1412–1420

    Article  PubMed  CAS  Google Scholar 

  27. Conrad KP, Benyo DF (1997) Placental cytokines and the pathogenesis of preeclampsia. Am J Reprod Immunol 37: 240–249

    Article  PubMed  CAS  Google Scholar 

  28. Conrad KP, Miles TM, Benyo DF (1998) Circulating levels of immunoreactive cytokines in women with preeclampsia. Am J Reprod Immunol 40: 102–111

    Article  PubMed  CAS  Google Scholar 

  29. Ramaswamy V, Horton J, Vendermeer B et al (2009) Systematic review of biomarkers of brain injury in term neonatal encephalopathy. Pediatr Neurol 40: 215–226

    Article  PubMed  Google Scholar 

  30. Girard S, Kadhim H, Roy M et al (2009) Role of perinatal inflammation in cerebral palsy. Pediatr Neurol 40: 168–174

    Article  PubMed  Google Scholar 

  31. Dammann O, O’Shea TM (2008) Cytokines and perinatal brain damage. Clin Perinatol 35: 643–663

    Article  PubMed  Google Scholar 

  32. Cholette JM, Ruberstein JS, Alfieris GM et al (2007) Elevated risk of thrombosis in neonates undergoing initial palliative cardiac surgery. Ann Thorac Surg 84: 1320–1325

    Article  PubMed  Google Scholar 

  33. Thornburg CD, Smith PB, Smithwick ML et al (2008) Association between thrombosis and bloodstream infection in neonates with peripherally inserted catheters. Thromb Res 122: 782–785

    Article  PubMed  CAS  Google Scholar 

  34. Manco-Johnson MJ (2006) How I treat venous thrombosis in children. Blood 107: 1–9

    Article  Google Scholar 

  35. Monagle P, Chalmers E, Chan A et al (2008) Antithrombotic therapy in neonates and children. Chest 133: 887S–968S

    Article  PubMed  CAS  Google Scholar 

  36. Kosch A, Kuwertz-Bröking E, Heller C et al (2004) Renal venous thrombosis in neonates: prothrombotic risk factors and long-term follow-up. Blood 104: 1356–1360

    Article  PubMed  CAS  Google Scholar 

  37. Nuss R, Hays T, Manco-Johnson M (1994) Efficacy and safety of heparin anticoagulation for neonatal renal vein thrombosis. Am J Pediatr Hematol Oncol 16: 127–131

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Section of Hematology/Oncology/Bone Marrow Transplant, and Hemophilia and Thrombosis Center, University of Colorado, Children’s Hospital Colorado, Aurora, Colorado, USA

    Marilyn J. Manco-Johnson

Authors
  1. Jennifer L. Armstrong-Wells
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  2. Marilyn J. Manco-Johnson
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Editor information

Editors and Affiliations

  1. Department of Pediatrics, Obstetrics and Reproductive Medicine, Division of Neonatology, University of Siena General Hospital S. Maria alle Scotte Azienda Ospedaliera Universitaria Senese, Siena, Italy

    Giuseppe Buonocore (Professor of Pediatrics and Neonatology, Head of School of Pediatrics) (Professor of Pediatrics and Neonatology, Head of School of Pediatrics)

  2. University of Siena, Siena, Italy

    Rodolfo Bracci (Formerly Professor of Pediatrics and Head of Department of Pediatrics, Obstetrics and Reproductive Medicine) (Formerly Professor of Pediatrics and Head of Department of Pediatrics, Obstetrics and Reproductive Medicine)

  3. University of Liverpool, UK

    Michael Weindling (Professor of Perinatal Medicine, Director of Postgraduate Research, Head of School of Paediatrics Mersey Deanery) (Professor of Perinatal Medicine, Director of Postgraduate Research, Head of School of Paediatrics Mersey Deanery)

  4. Department of Women’s and Children’s Health, Institute of Translational Medicine, Liverpool, UK

    Michael Weindling (Professor of Perinatal Medicine, Director of Postgraduate Research, Head of School of Paediatrics Mersey Deanery) (Professor of Perinatal Medicine, Director of Postgraduate Research, Head of School of Paediatrics Mersey Deanery)

  5. Liverpool Women’s Hospital, Liverpool, UK

    Michael Weindling (Professor of Perinatal Medicine, Director of Postgraduate Research, Head of School of Paediatrics Mersey Deanery) (Professor of Perinatal Medicine, Director of Postgraduate Research, Head of School of Paediatrics Mersey Deanery)

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© 2012 Springer-Verlag Italia

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Armstrong-Wells, J.L., Manco-Johnson, M.J. (2012). Coagulation Disorders: Inflammation and Thrombosis. In: Buonocore, G., Bracci, R., Weindling, M. (eds) Neonatology. Springer, Milano. https://doi.org/10.1007/978-88-470-1405-3_101

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  • DOI: https://doi.org/10.1007/978-88-470-1405-3_101

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1404-6

  • Online ISBN: 978-88-470-1405-3

  • eBook Packages: MedicineMedicine (R0)

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