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Neonatology pp 763-769 | Cite as

Coagulation Disorders: Risk of Thrombosis in the Newborn

  • Angelo C. Molinari
  • Paola Saracco

Abstract

Newborns comprise the largest group of children developing thromboembolism (TE), due to the peculiarities of their developmental hemostatic systems.

Keywords

Portal Vein Thrombosis MTHFR C677T Central Venous Line Renal Vein Thrombosis Healthy Neonate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Andrew M (1995) Developmental hemostasis: relevance to hemostatic problems during childhood. Semin Thromb Hemost 21: 341–356PubMedCrossRefGoogle Scholar
  2. 2.
    Stein PD, Kayali F, Olson RE (2004) Incidence of venous thromboembolism in infants and children: data from the National Hospital Discharge Survey. J Pediatr 145: 563–565PubMedCrossRefGoogle Scholar
  3. 3.
    Chalmers EA (2006) Epidemiology of venous thromboembolism in neonates and children. Thromb Res 118: 3–12PubMedCrossRefGoogle Scholar
  4. 4.
    Andrew M, David M, Adams M et al (1994) Venous thromboembolic complications (VTE) in children: first analyses of the Canadian Registry of VTE. Blood 83: 1251–1257PubMedGoogle Scholar
  5. 5.
    Nowak-Gottl U, von KR, Gobel U (1997) Neonatal symptomatic thromboembolism in Germany: two year survey. Arch Dis Child Fetal Neonatal Ed 76: F163–F167PubMedCrossRefGoogle Scholar
  6. 6.
    Schmidt B, Andrew M (1995) Neonatal thrombosis: report of a prospective Canadian and international registry. Pediatrics 96: 939–943PubMedGoogle Scholar
  7. 7.
    van Ommen CH, Heijboer H, Buller HR et al (2001) Venous thromboembolism in childhood: a prospective two-year registry in The Netherlands. J Pediatr 139: 676–681PubMedCrossRefGoogle Scholar
  8. 8.
    Monagle P, Barnes C, Ignjatovic V et al (2006) Developmental haemostasis. Impact for clinical haemostasis laboratories. Thromb Haemost 95: 362–372Google Scholar
  9. 9.
    Andrew M, Paes B, Milner R et al (1987) Development of the human coagulation system in the full-term infant. Blood 70: 165–172PubMedGoogle Scholar
  10. 10.
    Andrew M, Paes B, Milner R et al (1988) Development of the human coagulation system in the healthy premature infant. Blood 72: 1651–1657PubMedGoogle Scholar
  11. 11.
    Andrew M, Paes B, Johnston M (1990) Development of the hemostatic system in the neonate and young infant. Am J Pediatr Hematol Oncol 12: 95–104PubMedCrossRefGoogle Scholar
  12. 12.
    Khan S, Dickerman JD (2006) Hereditary thrombophilia. Thromb J 4: 15PubMedCrossRefGoogle Scholar
  13. 13.
    Saracco P, Parodi E, Fabris C et al (2009) Management and investigation of neonatal thromboembolic events: Genetic and acquired risk factors. Thromb Res 123: 805–809Google Scholar
  14. 14.
    Nowak-Gottl U, Debus O, Findeisen M et al (1997) Lipoprotein (a): its role in childhood thromboembolism. Pediatrics 99: E11PubMedCrossRefGoogle Scholar
  15. 15.
    Nowak-Gottl U, Junker R, Hartmeier M et al (1999) Increased lipoprotein (a) is an important risk factor for venous thromboembolism in childhood. Circulation 100: 743–748PubMedGoogle Scholar
  16. 16.
    von Depka M, Nowak-Gottl U, Eisert R et al (2000) Increased lipoprotein (a) levels as an independent risk factor for venous thromboembolism. Blood 96: 3364–3368Google Scholar
  17. 17.
    Manco-Johnson MJ, Grabowski EF, Hellgreen M et al (2002) Laboratory testing for thrombophilia in pediatric patients. On behalf of the subcommittee for perinatal and pediatric thrombosis of the scientific and standardization committee of the International Society of Thrombosis and Haemostasis ( ISTH ). Thromb Haemost 88: 155–156Google Scholar
  18. 18.
    Williams MD, Chalmers EA, Gibson BE (2002) The investigation and management of neonatal haemostasis and thrombosis. Br J Haematol 119: 295–309PubMedCrossRefGoogle Scholar
  19. 19.
    Adams-Chapman I, Vaucher YE, Bejar RF et al (2002) Maternal floor infarction of the placenta: association with central nervous system injury and adverse neurodevelopmental outcome. J Perinatol 22: 236–241PubMedCrossRefGoogle Scholar
  20. 20.
    Burke CJ, Tannenberg AE (1995) Prenatal brain damage and placental infarction—an autopsy study. Dev Med Child Neurol 37: 555–562PubMedCrossRefGoogle Scholar
  21. 21.
    Redline RW, Wilson-Costello D, Borawski E et al (1998) Placental lesions associated with neurologic impairment and cerebral palsy in very low-birth-weight in-fants. Arch Pathol Lab Med 122: 1091–1098PubMedGoogle Scholar
  22. 22.
    Clark P (2003) Changes of hemostasis variables during pregnancy. Semin Vasc Med 3: 13–24PubMedCrossRefGoogle Scholar
  23. 23.
    Golomb MR (2003) The contribution of prothrombotic disorders to peri- and neonatal ischemic stroke. Semin Thromb Hemost 29: 415–424PubMedCrossRefGoogle Scholar
  24. 24.
    Heilmann L, von Tempelhoff GF, Pollow K (2003) Antiphospholipid syndrome in obstetrics. Clin Appl Thromb Hemost 9: 143–150PubMedCrossRefGoogle Scholar
  25. 25.
    Knofler R, Hofmann S, Weissbach G et al (1998) Molecular markers of the endothelium, the coagulation and the fibrinolytic systems in healthy newborns. Semin Thromb Hemost 24: 453–461PubMedCrossRefGoogle Scholar
  26. 26.
    Shah JK, Mitchell LG, Paes B et al (1992) Thrombin inhibition is impaired in plasma of sick neonates. Pediatr Res 31: 391–395PubMedCrossRefGoogle Scholar
  27. 27.
    Aronis S, Platokouki H, Photopoulos S et al (1998) Indications of coagulation and/or fibrinolytic system activation in healthy and sick very-low-birth-weight neo-nates. Biol Neonate 74: 337–344PubMedCrossRefGoogle Scholar
  28. 28.
    Franzoi M, Simioni P, Luni S et al (2002) Effect of delivery modalities on the physiologic inhibition system of coagulation of the neonate. Thromb Res 105: 15–18PubMedCrossRefGoogle Scholar
  29. 29.
    Schmugge M, Bang KW, Blanchette VS et al (2007) Platelet activation and von Willebrand factor binding to platelets in newborn infants with central venous lines. Acta Haematol 117: 145–148PubMedCrossRefGoogle Scholar
  30. 30.
    Bokenkamp A, von KR, Nowak-Gottl U et al (2000) Neonatal renal venous thrombosis in Germany between 1992 and 1994: epidemiology, treatment and outcome. Eur J Pediatr 159: 44–48PubMedCrossRefGoogle Scholar
  31. 31.
    Kuhle S, Massicotte P, Chan A, Mitchell L (2004) A case series of 72 neonates with renal vein thrombosis. Data from the 1-800-NOCLOTS Registry. Thromb Haemost 92: 729–733PubMedGoogle Scholar
  32. 32.
    Lau KK, Stoffman JM, Williams S et al (2007) Neonatal renal vein thrombosis: review of the English-language literature between 199 and 2006. Pediatrics 120: e1278–e1284PubMedCrossRefGoogle Scholar
  33. 33.
    Ross P Jr, Ehrenkranz R, Kleinman CS, Seashore JH (1989) Thrombus associated with central venous catheters in infants and children. J Pediatr Surg 24: 253–256PubMedCrossRefGoogle Scholar
  34. 34.
    Morag I, Epelman M, Daneman A et al (2006) Portal vein thrombosis in the neonate: risk factors, course, and outcome. J Pediatr 148: 735–739PubMedCrossRefGoogle Scholar
  35. 35.
    Sanerkin NG, Edwards P, Jacobs J (1966) Pulmonary thromboembolic phenomena in the newborn. J Pathol Bacteriol 91: 569–574PubMedCrossRefGoogle Scholar
  36. 36.
    Andrew M (2000) Arterial thromboembolic complication in pediatric patients. In: Andrew M, Monagle PT, Brooker LA (eds) Thromboembolic complications during infancy and childhood. BC Decker, Hamilton, Ontario, pp 165–199Google Scholar
  37. 37.
    Monagle P, Adams M, Mahoney M et al (2000) Outcome of pediatric thromboembolic disease: a report from the Canadian Childhood Thrombophilia Registry. Pediatr Res 47: 763–766PubMedCrossRefGoogle Scholar
  38. 38.
    Berman W Jr, Fripp RR, Yabek SM et al (1991) Great vein and right atrial thrombosis in critically ill infants and children with central venous lines. Chest 99: 963–967PubMedCrossRefGoogle Scholar
  39. 39.
    John JB, Cron SG, Kung GC, Mott AR (2007) Intracardiac thrombi in pediatric patients: presentation profiles and clinical outcomes. Pediatr Cardiol 28: 213–220PubMedCrossRefGoogle Scholar
  40. 40.
    Marsh D, Wilkerson SA, Cook LN, Pietsch JB (1988) Right atrial thrombus formation screening using two-dimensional echocardiograms in neonates with central venous catheters. Pediatrics 81: 284–286PubMedGoogle Scholar
  41. 41.
    Manco-Johnson MJ, Sifontes M, Nuss R (1999) Coagulation abnormalities in neonatal catheter related thrombosis. Thromb Haemost 82 (suppl): 384Google Scholar
  42. 42.
    Nowak-Gottl U, Dubbers A, Kececioglu D et al (1997) Factor V Leiden, protein C, and lipoprotein (a) in catheterrelated thrombosis in childhood: a prospective study. J Pediatr 131: 608–612PubMedCrossRefGoogle Scholar
  43. 43.
    Revel-Vilk S, Chan A, Bauman M, Massicotte P (2003) Prothrombotic conditions in an unselected cohort of children with venous thromboembolic disease. J Thromb Haemost 1: 915–921PubMedCrossRefGoogle Scholar
  44. 44.
    Kosch A, Kuwertz-Broking E, Heller C et al (2004) Renal venous thrombosis in neonates: prothrombotic risk factors and long-term follow-up. Bloo 104: 1356–1360CrossRefGoogle Scholar
  45. 45.
    Boo NY, Wong NC, Zulkifli SS, Lye MS (1999) Risk factors associated with umbilical vascular catheter-associated thrombosis in newborn infants. J Paediatr Child Health 35: 460–465PubMedCrossRefGoogle Scholar
  46. 46.
    Cohen RS, Ramachandran P, Kim EH, Glasscock GF (1995) Retrospective analysis of risks associated with an umbilical artery catheter system for continuous monitoring of arterial oxygen tension. J Perinatol 15: 195–198PubMedGoogle Scholar
  47. 47.
    Nowak-Gottl U, Kosch A, Schlegel N (2003) Neonatal thromboembolism. Semin Thromb Hemost 29: 227–234PubMedCrossRefGoogle Scholar
  48. 48.
    Kenny D, Tsai-Goodman B (2007) Neonatal arterial thrombus mimicking congenital heart disease. Arch Dis Child Fetal Neonatal Ed 92: F59–F61PubMedCrossRefGoogle Scholar
  49. 49.
    Moreno-Cabral RJ, Breitweser JA (1983) Pulmonary embolectomy in the neonate. Chest 84: 502–504PubMedCrossRefGoogle Scholar
  50. 50.
    Gamillscheg A, Nurnberg JH, exi-Meskishvili V et al (1997) Surgical emergency embolectomy for the treatment of fulminant pulmonary embolism in a preterm infant. J Pediatr Surg 32: 1516–1518PubMedCrossRefGoogle Scholar
  51. 51.
    Feldman JP, Feinstein JA, Lamberti JJ, Perry SB (2005) Angiojet catheter-based thrombectomy in a neonate with postoperative pulmonary embolism. Catheter Cardiovasc Interv 66: 442–445PubMedCrossRefGoogle Scholar
  52. 52.
    Roach ES, Golomb MR, Adams R et al (2008) Management of stroke in infants and children: a scientific statement from a special writing group of the American heart Association Stroke Council and the Council on Cardiovascular Disease in the Young. Stroke 39: 2644–2691PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Angelo C. Molinari
    • 1
  • Paola Saracco
  1. 1.Thrombosis and Hemostasis Unit, Department of Hematology and OncologyGiannina Gaslini Children’s HospitalGenoaItaly

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