Radionuclide Imaging of Musculoskeletal Infections

  • Katrin D. M. Stumpe


Conventional nuclear medicine offers a variety of different methods for the diagnosis of musculoskeletal infections, including three-phase bone scintigraphy, gallium imaging, and labeled leukocyte imaging with indium-111 (111In)-oxine or Tc-99-hexamethyl-propyleneamine oxime (HMPAO) and labeled antibodies against leukocyte surface antigens (antigranulocyte antibodies). However, most of the conventional radionuclide imaging techniques are of low specificity in the detection of low-grade and chronic infections, especially in the axial skeleton due to high physiological uptake in normal bone marrow of the spine.


Bone Scintigraphy Aseptic Loosening Chronic Osteomyelitis Musculoskeletal Infection Pyogenic Vertebral Osteomyelitis 


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Copyright information

© Springer-Verlag Italia 2009

Authors and Affiliations

  • Katrin D. M. Stumpe
    • 1
  1. 1.Nuclear Medicine, Department of Medical RadiologyUniversity HospitalZurichSwitzerland

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