Riassunto
Il magnesio è il catione intracellulare più abbondante dopo il potassio. Il contenuto corporeo in un uomo di 70 kg è di circa 1750 mEq. Di questo, l’1% è extracellulare, il 31% è contenuto nelle cellule e il 67% è presente nell’osso. Nel plasma il magnesio è presente in concentrazioni variabili tra 1,8 e 3 mg/dl, per il 30% legato alle proteine (soprattutto albumina) e per il rimanente sotto forma ionizzata [1]. Il magnesio svolge un ruolo essenziale in un gran numero di reazioni cellulari per la sua capacità di legarsi con enzimi e altre strutture cellulari come le proteine, gli acidi nucleici e le lipoproteine. Poiché gran parte del magnesio all’interno delle cellule è legato all’adenosina trifosfato (ATP), variazioni della concentrazione del magnesio libero ne possono alterare i depositi e compromettere la corretta funzione cellulare. Il magnesio partecipa all’attività di oltre 300 sistemi enzimatici.
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Martini, G., Salvadori, S., Nuti, R. (2009). Ipomagnesiemia e ipermagnesiemia. In: Osteoporosi e malattie metaboliche dell’osso. Springer, Milano. https://doi.org/10.1007/978-88-470-1357-5_21
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DOI: https://doi.org/10.1007/978-88-470-1357-5_21
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