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General Considerations

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Book cover Fundamentals in Oncologic Ultrasound

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Abstract

US has a number of characteristics which make it a very useful diagnostic technique both for general application and for oncology in particular. First of all, US is a simple technique. This simplicity, which is sometimes confused with ease of use, is related to the way the examination is performed. No preliminary analysis or special preparation is required and it can always be immediately carried out, making it much more accessible in any hospital setting than the “heavy” devices of CT and MR. The immediacy of the image is another advantage, whereby the clinical picture may be clarified at the very time the US transducer is placed on the skin in the anatomic area in question. In addition, the rapidity of the examination is an important characteristic, particularly in other areas, such as emergency medicine. In oncology, however, a careful and comprehensive study is recommended, which slowly and repeatedly explores all the anatomic areas involved in the examination in question. This is particularly important in the “positive” patient: a pathologic finding indicating malignancy in a particular organ should increase the level of attention of the US operator due to the elevated probability that there are other associated findings.

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References

  1. Belton AL et al (2003) Tumour size measurement in an oncology clinical trial: comparison between off-site and onsite measurements. Clin Radiol 58:311–314

    CAS  PubMed  Google Scholar 

  2. Catalano O et al (2004) Ethical, deontologic, social, and economic reflections on screening with helical CT. Part I: general aspects. Radiol Med 108:299–309

    PubMed  Google Scholar 

  3. Catalano O et al (2004) Ethic, deontologic, social, and economic reflections on screening with helical CT. Part II: specific aspects. Radiol Med 108:310–319

    PubMed  Google Scholar 

  4. Black WC et al (1997) Screening for disease. AJR Am J Roentgenol 168:3–11

    CAS  PubMed  Google Scholar 

  5. Herman CR et al (2002) Screening for preclinical disease. Test and disease characteristics. AJR Am J Roentgenol 179:825–831

    PubMed  Google Scholar 

  6. Stanley RJ (2001) Inhert dangers in radiologic screening. AJR Am J Roentgenol 177:989–992

    CAS  PubMed  Google Scholar 

  7. Obuchowski NA et al (2001) Ten criteria for effective screening: their application to multislice CT screening for pulmonary and colorectal cancers. AJR Am J Roentgenol 176:1357–1362

    CAS  PubMed  Google Scholar 

  8. Baker SR (2003) Abdominal CT screening: inflated promises, serious concerns. AJR Am J Roentgenol 180:27–30

    PubMed  Google Scholar 

  9. Berg WA (2004) Supplemental screening sonography in dense breasts. Radiol Clin North Am 42:845–851

    PubMed  Google Scholar 

  10. Eden K et al (2001) Screening high-risk populations for thyroid cancer. Med Pediatr 36:583–591

    CAS  Google Scholar 

  11. Suehiro F (2006) Thyroid cancer detected by mass screening over a period of 16 years at a health care center in Japan. Surg Today 36:947–953

    PubMed  Google Scholar 

  12. Park JS et al (2006) Sonographic screening for thyroid cancer in females undergoing breast sonography. AJR Am J Roentgenol 186:1025–1028

    PubMed  Google Scholar 

  13. Kane RA et al (2003) Ultrasound of the thyroid and parathyroid glands. Controversies in the diagnosis of thyroid cancer. Ultrasound Q 19:177–178

    PubMed  Google Scholar 

  14. Mihmanli I et al (2006) Concurrent routine breast and thyroid sonography for detection of thyroid tumors (letter). AJR Am J Roentgenol 187:W448

    PubMed  Google Scholar 

  15. Miki H et al (1998) Value of mass screening for thyroid cancer. World J Surg 22:99–102

    CAS  PubMed  Google Scholar 

  16. Clements R (2001) Ultrasound of prostate cancer. Eur Radiol 11:2119–2125

    CAS  PubMed  Google Scholar 

  17. Sharma A et al (2006) Screening for gynaecological cancers. Eur J Surg Oncol 32:818–824

    CAS  PubMed  Google Scholar 

  18. Ascher SM et al (2002) Cancer of the adnexal organs. In: Bragg DG et al (eds) Oncologic imaging. WB Saunders Company, Philadelphia, 549–574

    Google Scholar 

  19. Hensley ML et al (2004) Cancer screening: how good is good enough?. J Clin Oncol 22:4037–4039

    PubMed  Google Scholar 

  20. De Priest PD et al (1992) Transvaginal ultrasound screening for ovarian cancer. Clin Obstet Gynecol 35:40–44

    Google Scholar 

  21. Jeong et al (2000) Imaging evaluation of ovarian masses. Radiographics 20:1445–1470

    CAS  PubMed  Google Scholar 

  22. Jacobs I et al (1993) Prevalence screening for ovarian cancer in postmenopausal women by CA-125 measurement and ultrasonography. BMJ 306:1030–1034

    CAS  PubMed  Google Scholar 

  23. Valenzano M et al (2001) The role of transvaginal ultrasound and sonohysterography in the diagnosis and staging of endometrial adenocarcinoma. Radiol Med 101:365–370

    CAS  PubMed  Google Scholar 

  24. Vuento MH et al (1999) Screening for endometrial cancer in asymptomatic postmenopausal women with conventional and color Doppler sonography. Br J Obstet Gynaecol 106:14–20

    CAS  PubMed  Google Scholar 

  25. Fleischer AC (1997) Transvaginal sonography of endometrial cancer. In: Fleischer AC et al (eds) Ultrasound and the endometrium. Parthenon Publishing Group, New York, 69–74

    Google Scholar 

  26. Kim B et al (2003) Testicular microlithiasis: clinical significance and review of the literature. Eur Radiol 13:2567–2576

    PubMed  Google Scholar 

  27. de Leval J et al (1993) Testis tumor: the problem of the undescended testis. J Belge Radiol 76:100–101

    PubMed  Google Scholar 

  28. Giwercman A et al (1989) Prevalence of carcinoma in situ and other histopatological abnormalities in the testes of men with a history of cryptorchidism. J Urol 142:998–1002

    CAS  PubMed  Google Scholar 

  29. Miller FN et al (2007) Testicular calcification and microlithiasis: association with primary intra-testicular malignancy in 3,477 patients. Eur Radiol 17:363–369

    PubMed  Google Scholar 

  30. Rashid HH et al (2004) Testicular microlithiasis: a review and its association with testicular cancer. Urol Oncol 22:285–289

    PubMed  Google Scholar 

  31. Bruix J et al (2005) Management of hepatocellular carcinoma. Hepatology 42:1208–1236

    PubMed  Google Scholar 

  32. Colombo M (2005) Natural history of hepatocellular carcinoma. Cancer Imaging 5:85–88

    PubMed  Google Scholar 

  33. Rockall TA et al (2004) Multidisciplinary treatment for cancer: surgery, chemotherapy and radiotherapy. In: Husband JE et al (eds) Imaging in oncology. Taylor & Francis, London, 43–65

    Google Scholar 

  34. Sangiovanni A et al (2004) Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance. Gastroenterology 126:1005–1014

    PubMed  Google Scholar 

  35. Ren F-Y et al (2006) Efficacy of ultrasonography and alphafetoprotein on early detection of hepatocellular carcinoma. World J Gastroenterol 12:4656–4659

    PubMed  Google Scholar 

  36. Arguedas MR et al (2003) Screening for hepatocellular carcinoma in patients with hepatitis C cirrhosis: a costutility analysis. Am J Gastroenterol 98:679–690

    PubMed  Google Scholar 

  37. Peterson MS et al (2000) Pretransplantation surveillance for possible hepatocellular carcinoma in patients with cirrhosis: epidemiology and CT-based tumor detection rate in 430 cases with surgical-pathologic correlation. Radiology 217:743–749

    CAS  PubMed  Google Scholar 

  38. Federle MP (2002) Use of radiologic techniques to screen for hepatocellular carcinoma. J Clin Gastroenterol 35 (5 Suppl 2):92–100

    Google Scholar 

  39. Kubota K et al (2003) Growth rate of primary single hepatocellular carcinoma: determining optimal screening interval with contrast enhanced computed tomography. Dig Dis Sci 48:581–586

    PubMed  Google Scholar 

  40. Majima Y (1984) Growth rate of hepatocellular carcinoma by ultrasonography and its clinical significance. Acta Hepatol Jpn 25:754–765

    Google Scholar 

  41. Hirata K et al (1997) Mass screening for hepatocellular carcinoma by ultrasonography In: Gandolfi L et al (eds), Current trends in digestive ultrasonography. Karger, Basel, 17–27

    Google Scholar 

  42. Bennett GL et al (2002) Sonographic detection of hepatocellular carcinoma and dysplastic nodules in cirrhosis: correlation of pretransplantation sonography and liver explant pathology in 200 patients. AJR Am J Roentgenol 179:75–80

    PubMed  Google Scholar 

  43. Dodd GD et al (1992) Detection of malignant tumors in endstage cirrhosis livers: efficacy of sonography as a screening technique. AJR Am J Roentgenol 159:727–733

    PubMed  Google Scholar 

  44. Liu WC et al (2003) Poor sensitivity of sonography in detection of hepatocellular carcinoma in advanced liver cirrhosis: accuracy of pretransplantation sonography in 118 patients. Eur Radiol 13:1693–1698

    PubMed  Google Scholar 

  45. Bruix J et al (2001) Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 35:4214–30

    Google Scholar 

  46. Bosniak MA et al (1995) Small renal parenchymal neoplasms: further observations on growth. Radiology 197:589–597

    CAS  PubMed  Google Scholar 

  47. Jamis-Dow CA et al (1996) Small (≤3-cm) renal masses: detection with CT versus US and pathologic correlation. Radiology 198:785–788

    CAS  PubMed  Google Scholar 

  48. Mihara S et al (1998) Efficacy of ultrasonic mass survey for abdominal cancer. J Med Syst 22:55–62

    CAS  PubMed  Google Scholar 

  49. Mihara S et al (1999) Early detection of renal cell carcinoma by ultrasonographic screening. Based on the results of 13 years screening in Japan. Ultrasound Med Biol 25:1033–1039

    CAS  PubMed  Google Scholar 

  50. Jeswani T et al (2005) Imaging tumour angiogenesis. Cancer Imaging 5:131–138

    PubMed  Google Scholar 

  51. Nishida T (2005) Angiogenesis, which is essential for cancer growth, is a diagnostic and therapeutic target. J Gastroenterol 40:320–321

    PubMed  Google Scholar 

  52. Kelland LR (2005) Targeting established tumor vasculature: a novel approach to cancer treatment. Curr Cancer Ther Rev 1:1–9

    Google Scholar 

  53. Rehman S et al (2005) Molecular imaging of antiangiogenic agents. Oncologist 10:92–103

    CAS  PubMed  Google Scholar 

  54. Cuenod CA et al (2006) Tumor angiogenesis: pathophysiology and implications for contrast-enhanced MRI and CT assessment. Abdom Imaging 31:188–193

    CAS  PubMed  Google Scholar 

  55. Cosgrove D (2003) Angiogenesis imaging — ultrasound. Br J Radiol 76:S43–S49

    PubMed  Google Scholar 

  56. Anderson H et al (2001) Measuring changes in human tumour vasculature in response to therapy using functional imaging techniques. Br J Cancer 85:1085–1093

    CAS  PubMed  Google Scholar 

  57. Forsberg F et al (2002) Comparing contrast-enhanced ultrasound to immunohistochemical markers of angiogenesis in a human melanoma xenograft model: preliminary results. Ultrasound Med Biol 28:445–451

    PubMed  Google Scholar 

  58. Provenzale JM (2007) Imaging of angiogenesis: clinical techniques and novel imaging methods. AJR Am J Roentgenol 188:11–23

    PubMed  Google Scholar 

  59. Ferrara KW et al (2000) Evaluation of tumor angiogenesis with US: imaging, Doppler, and contrast agents. Acad Radiol 7:824–839

    CAS  PubMed  Google Scholar 

  60. Delorme S et al (2006) Contrast-enhanced ultrasound for examining tumor biology. Cancer Imaging 6:148–152

    PubMed  Google Scholar 

  61. Kruskal JB et al (2006) Will improved assessment of response to antiangiogenic therapies be achieved with contrast-enhanced gray-scale US?. Radiology 240:1–2

    PubMed  Google Scholar 

  62. Cosgrove D (2003) Angiogenesis imaging-ultrasound. Br J Radiol 76:S43–S49

    PubMed  Google Scholar 

  63. Blomley MJ et al (1998) Liver vascular transit time analyzed with dynamic hepatic venography with bolus injections of a US contrast agent: early experience in seven patients with metastases. Radiology 209:862–866

    CAS  PubMed  Google Scholar 

  64. Donnelly EF et al (2001) Quantified power Doppler US of tumor blood flow correlates with microscopic quantification of tumor blood vessels. Radiology 219:166–170

    CAS  PubMed  Google Scholar 

  65. Schroeder RJ et al (2001) Tumor vascularization in experimental melanomas: correlation between unenhanced and contrast enhanced power Doppler imaging and histological grading. Ultrasound Med Biol 27:761–771

    CAS  PubMed  Google Scholar 

  66. Lassau N et al (2006a) Gastrointestinal stromal tumors treated with Imatinib: monitoring response with contrast-enhanced sonography. AJR Am J Roentgenol 187:1267–1273

    PubMed  Google Scholar 

  67. Lucidarme O et al (2004) Angiogenesis model for ultrasound contrast research: exploratory study. Acad Radiol 11:4–12

    PubMed  Google Scholar 

  68. Pollard RE et al (2002) Contrast-assisted destruction-replenishment ultrasound for the assessment of tumor microvasculature in a rate model. Technol Cancer Res Treat 1:459–470

    PubMed  Google Scholar 

  69. Fleischer AC et al (2008) Contrast-enhanced transvaginal sonography of benign versus malignant ovarian masses: preliminary findings. J Ultrasound Med 27:1011–1018

    PubMed  Google Scholar 

  70. Li J et al (2005) Time-intensity-based quantification of vascularity with single-level dynamic contrast-enhanced ultrasonography. A pilot animal study. J Ultrasound Med 24:975–983

    PubMed  Google Scholar 

  71. Rubaltelli L et al (2007) Automated quantitative evaluation of lymph node perfusion on contrast-enhanced sonography. AJR Am J Roentgenol 188:977–983

    PubMed  Google Scholar 

  72. Du J et al (2008) Correlation of real-time gray scale contrast-enhanced ultrasonography with microvessel density and vascular endothelial growth factor expression for assessment of angiogenesis in breast lesions. J Ultrasound Med 27:821–831

    PubMed  Google Scholar 

  73. McCarville MB et al (2006) Angiogenesis inhibitors in a murine neuroblastoma model: quantitative assessment of intratumoral blood flow with contrast-enhanced gray-scale US. Radiology 240:73–81

    PubMed  Google Scholar 

  74. Krix M et al (2003) Sensitive noninvasive monitoring of tumor perfusion during antiangiogenic therapy by intermittent bolus-contrast power Doppler sonography. Cancer Res 63:8264–8270

    CAS  PubMed  Google Scholar 

  75. Galiè M et al (2005) Tumor vessel compression hinders perfusion of ultrasonographic contrast agents. Neoplasia 7:528–536

    PubMed  Google Scholar 

  76. Lindner JR (2004) Molecular imaging with contrast ultrasound and target microbubbles. J Nucl Cardiol 11:215–221

    PubMed  Google Scholar 

  77. Neal AJ (2004) Staging of cancer. In: Husband JE et al (eds) Imaging in oncology. Taylor & Francis, London, 31–41

    Google Scholar 

  78. Wittekind Ch et al (2005) TNM atlas. Springer-Verlag Berlin.

    Google Scholar 

  79. Ferrozzi F et al (2002) Structural changes induced by antineoplastic therapies: keys to evaluate tumor response to treatment. Eur Radiol 12:928–937

    CAS  PubMed  Google Scholar 

  80. Husband JE (1996) Monitoring tumor response. Eur Radiol 6:775–785

    CAS  PubMed  Google Scholar 

  81. Lagalla R et al (1998b) Monitoring treatment response with color and power Doppler Eur J Radiol 28:149–156

    Google Scholar 

  82. MacVicar D et al (1997) Assessment of response following treatment for malignant disease. Br J Radiol 70:41–49

    Google Scholar 

  83. Miller AB et al (1981) Reporting results of cancer treatment. Cancer 47:207–214

    CAS  PubMed  Google Scholar 

  84. Therasse P et al (2000) New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 92:205–216

    CAS  PubMed  Google Scholar 

  85. Therasse P et al (2006) RECIST revisited: a review of validation studies on tumour assessment. Eur J Cancer 42:1031–1039

    CAS  PubMed  Google Scholar 

  86. Park SH et al (2004) Volumetric tumor measurement using three-dimensional ultrasound: in vitro phantom study on measurement accuracy under various scanning condition. Ultrasound Med Biol 30:27–34

    PubMed  Google Scholar 

  87. Bellomi M et al (2004) Evaluation of the response to therapy of neoplastic lesions. Radiol Med 107:450–458

    PubMed  Google Scholar 

  88. Ollivier L et al (2002) Monitoring tumor response. Cancer Imaging 3:5–6

    Google Scholar 

  89. Prasad SR et al (2003a) Radiological evaluation of oncologic treatment response: current update. Cancer Imaging 3:93–95

    Google Scholar 

  90. Catalano O et al (1999) Hepatocellular carcinoma treated with chemoembolization: assessment with contrast-enhanced Doppler ultrasonography. Cardiovasc Intervent Radiol 22:486–492

    CAS  PubMed  Google Scholar 

  91. Gee MS et al (2001) Doppler ultrasound imaging detects changes in tumor perfusion during antivascular therapy associated with vascular anatomic alterations Cancer Res 61:2974–2982

    CAS  PubMed  Google Scholar 

  92. Miller JC et al (2005) Imaging angiogenesis: applications and potential for drug development. J Natl Cancer Inst 97:172–187

    CAS  PubMed  Google Scholar 

  93. De Giorgi U et al (2005) Effect of angiosonography to monitor response during Imatinib treatment in patients with metastatic gastrointestinal stromal tumors. Clin Cancer Res 11:6171–6176

    PubMed  Google Scholar 

  94. Krix M (2005) Quantification of enhancement in contrast ultrasound: a tool for monitoring of therapies in liver metastases. Eur Radiol 15(Suppl 5):104–108

    Google Scholar 

  95. giovagnoni A et al (2005) Evidence Based Medicine (EBM) and Evidence Based Radiology (EBR) in the follow-up of the patients after surgery for lung and colonrectal carcinoma. Radiol Med 109:345–357

    PubMed  Google Scholar 

  96. Liberati A et al (1997) Assessing the effectiveness of follow-up care for colorectal cancer: a great conceptual and methodological challenge for clinical oncology. Ann Oncol 8:1059–1062

    CAS  PubMed  Google Scholar 

  97. Puylaert JB (1986) Acute appendicitis: US evaluation using graded compression Radiology 158:355–360

    CAS  PubMed  Google Scholar 

  98. Testa AC et al (2005) The use of contrasted transvaginal sonography in the diagnosis of gynecologic diseases. A preliminary study. J Ultrasound Med 24:1267–1278

    PubMed  Google Scholar 

  99. Menzel J et al (2000) Gastrointestinal miniprobe sonography: the current status. Am J Gastroenterol 95:605–616

    CAS  PubMed  Google Scholar 

  100. Harvey CJ et al (2002) Advances in ultrasound. Clin Radiol 57:157–177

    PubMed  Google Scholar 

  101. Madrazo BL et al (2000) Doppler imaging. In: Shirkhoda A (eds) Variants and pitfalls in body imaging. Lippincott Williams & Wilkins, Philadelphia, 455–473

    Google Scholar 

  102. Lencioni R et al (2002) Tissue harmonic and contrast-specific imaging: back to gray scale in ultrasound. Eur Radiol 12:151–165

    PubMed  Google Scholar 

  103. Szopinski KT et al (2003) Tissue harmonic imaging. Utility in breast sonography. J Ultrasound Med 22:479–487

    PubMed  Google Scholar 

  104. Cha JH et al (2007) Characterization of benign and malignant solid breast masses: comparison of conventional US and tissue harmonic imaging. Radiology 242:63–69

    PubMed  Google Scholar 

  105. Desser TS et al (2000) Native tissue harmonic imaging: basic principles and clinical applications Ultrasound Q 16:40–48

    Google Scholar 

  106. Rosenthal SJ et al (2001) Phase inversion tissue harmonic sonographic imaging: a clinical utility study. AJR Am J Roentgenol 176:1393–1398

    CAS  PubMed  Google Scholar 

  107. Entrekin RR et al (2001) Real-time spatial compound imaging: application to breast, vascular, and musculoskeletal ultrasound. Semin Ultrasound CT MR 22:50–64

    CAS  PubMed  Google Scholar 

  108. Oktar SÖ et al (2003) Comparison of conventional sonography, real-time compound sonography, tissue harmonic sonography, and tissue harmonic compound sonography of abdominal and pelvic lesions. AJR Am J Roentgenol 181:1341–1347

    PubMed  Google Scholar 

  109. Mehta TS (2003) Current uses of ultrasound in the evaluation of the breast. Radiol Clin North Am 41:841–856

    PubMed  Google Scholar 

  110. Kim SE et al (2003) Extended field-of-view sonography. Advantages in abdominal applications. J Ultrasound Med 22:385–394

    PubMed  Google Scholar 

  111. Henrich W et al (2002) Transvaginal and transabdominal extended field-of-view (EFOV) and power Doppler EFOV sonography in gynecology. Advantages and applications J Ultrasound Med 21:1137–1144

    PubMed  Google Scholar 

  112. Ying M et al (2006) Reliability of 3-D ultrasound measurements of cervical lymph node volume. Ultrasound Med Biol 32:995–1001

    PubMed  Google Scholar 

  113. Bega G et al (2003) Three-dimensional ultrasonography in gynecology. Technical aspects and clinical applications J Ultrasound Med 22:1249–1269

    PubMed  Google Scholar 

  114. Lyshchik A et al (2004) Three-dimensional ultrasonography for volume measurement of thyroid nodules in children. J Ultrasound Med 23:247–254

    PubMed  Google Scholar 

  115. Alam F et al (2008) Accuracy of sonographic elastography in the differential diagnosis of enlarged cervical lymph nodes: comparison with conventional B-mode sonography AJR Am J Roentgenol 191:604–610

    PubMed  Google Scholar 

  116. Giuseppetti GM et al (2005) Elastosonography in the diagnosis of the nodular breast lesions: preliminary report. Radiol Med 110:69–76

    PubMed  Google Scholar 

  117. Zhi H et al (2007) Comparison of ultrasound elastography, mammography, and sonography in the diagnosis of solid breast lesions. J Ultrasound Med 26:807–815

    PubMed  Google Scholar 

  118. Wachsberg RH (2003) B-flow, a non-Doppler technology for flow mapping: early experience in the abdomen. Ultrasound Q 19:114–122

    PubMed  Google Scholar 

  119. Youk JK et al (2005) Focal fibrosis of the breast diagnosed by a sonographically guided core biopsy of nonpalpable lesions. Imaging findings and clinical relevance. J Ultrasound Med 24:1377–1384

    Google Scholar 

  120. Konno K et al (2001) Liver tumors in fatty liver: difficulty in ultrasonographic interpretation. Abdom Imaging 26:487–491

    CAS  PubMed  Google Scholar 

  121. Riccabona M et al (1995) Distance and volume measurement using three-dimensional ultrasonography. J Ultrasound Med 14:881–886

    CAS  PubMed  Google Scholar 

  122. Nishino M et al (2003) Primary retroperitoneal neoplasms: CT and MR imaging findings with anatomic and pathologic diagnostic clues. Radiographics 23:45–57

    PubMed  Google Scholar 

  123. Moody AR et al (1993) Atypical hepatic hemangioma: a suggestive sonographic morphology. Radiology 188:413–417

    CAS  PubMed  Google Scholar 

  124. Blachar A et al (2002) Hepatic capsular retraction: spectrum of benign and malignant etiologies. Abdom Imaging 27:690–699

    CAS  PubMed  Google Scholar 

  125. Middleton WD (1998) Color Doppler. Image interpretation and optimization. Ultrasound Q 14:194–208

    Google Scholar 

  126. Taylor KJ (1995) Fulse Doppler and color flow of tumors. In: Taylor KJW et al (eds) Clinical applications of Doppler ultrasound, Raven Press, New York, 355–366

    Google Scholar 

  127. Grenier N et al (2001) Interpretation of Doppler signals. Eur Radiol 11:1295–1307

    CAS  PubMed  Google Scholar 

  128. Hata K et al (2002) Prognostic significance of ultrasound derived peak systolic velocity in epithelial ovarian cancer. Ultrasound Obstet Gynecol 20:186–191

    CAS  PubMed  Google Scholar 

  129. Kaushik S et al (2003) Spectral Doppler sonography of musculoskeletal soft tissue masses. J Ultrasound Med 22:1333–1336

    PubMed  Google Scholar 

  130. del Cura JL et al (2005) The use of unenhanced Doppler sonography in the evaluation of solid breast lesions. AJR Am J Roentgenol 184:1788–1794

    PubMed  Google Scholar 

  131. Özdemir A et al (2001) Differential diagnosis of solid breast lesions J Ultrasound Med 20:1091–1101

    PubMed  Google Scholar 

  132. Bodner G et al (2002) Differentiation of malignant and benign musculoskeletal tumors: combined color and power Doppler US and spectral wave analysis. Radiology 223:410–416

    PubMed  Google Scholar 

  133. Schick S et al (1998) Differentiation of benign and malignant tumors of the parotid gland: value of pulsed Doppler and color Doppler sonography. Eur Radiol 8:1462–1467

    CAS  PubMed  Google Scholar 

  134. Hata K et al (1995) Intratumoral peak systolic velocity as a new possible predictor for detection of adnexal malignancy. Am J Obstet Gynecol 172:1496–1500

    CAS  PubMed  Google Scholar 

  135. Brniç Z et al (2003) Usefulness of Doppler waveform analysis in differential diagnosis of cervical lymphadenopathy. Eur Radiol 13:175–180

    PubMed  Google Scholar 

  136. Peters-Engl C et al (1999) Tumor flow in malignant breast tumors measured by Doppler ultrasound: an independent predictor of survival Breast Cancer Res Treat 54:65–71

    CAS  PubMed  Google Scholar 

  137. Kubota K et al (2000) Evaluation of the intratumoral vasculature of hepatocellular carcinoma by power Doppler sonography: advantages and disadvantages versus conventional color Doppler sonography. Abdom Imaging 25:172–178

    CAS  PubMed  Google Scholar 

  138. Schroeder RJ et al (2003) Role of power Doppler techniques and ultrasound contrast enhancement in the differential diagnosis of focal breast lesions. Eur Radiol 13:68–79

    PubMed  Google Scholar 

  139. Quaia E (2005) Contrast media in ultrasonography. Basic principles and clinical applications Springer, Berlin

    Google Scholar 

  140. Wilson WD et al (2006) Sonographic quantification of ovarian tumor vascularity. J Ultrasound Med 25:1577–1581

    PubMed  Google Scholar 

  141. Epstein E et al (2002) An algorithm including results of gray-scale and power Doppler ultrasound examination to predict endometrial malignancy in women with postmenopausal bleeding. Ultrasound Obstet Gynecol 20:370–376

    CAS  PubMed  Google Scholar 

  142. De Marchi A et al (2002) A preliminary experience in the study of soft tissue superficial masses: color Doppler US and wash-in and wash-out curves with contrast media compared to histological results. Radiol Med 104:451–458

    PubMed  Google Scholar 

  143. Numata K et al (1997) Use of hepatic tumor index on color Doppler sonography for differentiating large hepatic tumors. AJR Am J Roentgenol 168:991–995

    CAS  PubMed  Google Scholar 

  144. Jeffrey RB et al (1995) Sonography of the abdomen. Raven Press, New York

    Google Scholar 

  145. Tanaka S et al (1990) Color-Doppler imaging of liver tumors. AJR Am J Roentgenol 154:509–514

    CAS  PubMed  Google Scholar 

  146. Bartolozzi C et al (2001) contrast-specific ultrasound imaging of focal liver lesions. Prologue to a promising future. Eur Radiol 11(Suppl 3):13–14

    Google Scholar 

  147. Harvey CJ et al (2001) Developments in ultrasound contrast media. Eur Radiol 11:675–689

    CAS  PubMed  Google Scholar 

  148. Liu J-B et al (2008) Contrast-enhanced ultrasound imaging. In: McGahan JP et al (eds) Diagnostic ultrasound, II edition. Informa Healthcare, New York, 39–62

    Google Scholar 

  149. Correas J-M et al (2001) Ultrasound contrast agents: properties, principles of action, tolerance, and artifacts. Eur Radiol 11:1316–1328

    CAS  PubMed  Google Scholar 

  150. Piscaglia F et al (2006) The safety of Sono Vue® in abdominal applications: retrospective analysis of 23188 investigations. Ultrasound Med Biol 32:1369–1375

    PubMed  Google Scholar 

  151. Forsberg F et al (1999) Tissue-specific US contrast agent for evaluation of hepatic and splenic parenchyma. Radiology 210:125–132

    CAS  PubMed  Google Scholar 

  152. Numata K et al (2008) Ablation therapy guided by contrast-enhanced sonography with sonazoid for hepatocellular carcinoma lesions not detected by conventional sonography. J Ultrasound Med 27:395–406

    PubMed  Google Scholar 

  153. Catalano O et al (2007b) Terminology for contrast-enhanced sonography: a practical glossary. J. Ultrasound Med 26:717–730

    PubMed  Google Scholar 

  154. Bauer A et al (2002) Ultrasound imaging with Sono Vue: low mechanical index real-time imaging. Acad Radiol 9(Suppl 1): 282–284

    Google Scholar 

  155. Forsberg F et al (1994) Artifacts in ultrasonic contrast agent studies. J Ultrasound Med 13:357–365

    CAS  PubMed  Google Scholar 

  156. Chami L et al (2007) Benefits of contrast-enhaced sonography for the detection of liver lesions: comparison with histologic findings AJR Am J Roentgenol 190:683–690

    Google Scholar 

  157. Claudon M et al (2008) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS)-update 2008. Ultraschall Med 29:28–44

    CAS  PubMed  Google Scholar 

  158. Catalano O et al (2005a) Real-time harmonic contrast material-specific US of focal liver lesions. Radiographics 25:333–349

    PubMed  Google Scholar 

  159. Isozaki T et al (2003) Differential diagnosis of hepatic tumors by using contrast enhancement patterns at US. Radiology 229:798–805

    PubMed  Google Scholar 

  160. Minami Y et al (2004) Treatment of hepatocellular carcinoma with radiofrequency ablation: usefulness of contrast harmonic sonography for lesions poorly defined with B-mode sonography. AJR Am J Roentgenol 183:153–156

    PubMed  Google Scholar 

  161. Solbiati L et al (1997) Hepatic metastases: percutaneous radiofrequency ablation with cooled-tip electrodes. Radiology 205:367–373

    CAS  PubMed  Google Scholar 

  162. Quaia E et al (2007) Diagnostic value of hepatocellular nodule vascularity after microbubble injection for characterizing malignancy in patients with cirrhosis. AJR Am J Roentgenol 189:1474–1483

    PubMed  Google Scholar 

  163. Burns PN et al (2007) Focal liver masses: enhancement patterns of contrast-enhanced images-concordance of US scans with CT scans and MR images. Radiology 242:162–174

    PubMed  Google Scholar 

  164. Catalano O et al (2006a) Contrast-enhanced sonography of the spleen. Semin Ultrasound CT and MRI 27:426–433

    Google Scholar 

  165. Thorelius L (2003) Contrast-enhanced ultrasound: beyond the liver. Eur Radiol 13(Suppl 3): 91–108

    Google Scholar 

  166. Robbin ML et al (2003) Renal imaging with ultrasound contrast: current status. Radiol Clin North Am 41:963–978

    PubMed  Google Scholar 

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(2009). General Considerations. In: Fundamentals in Oncologic Ultrasound. Springer, Milano. https://doi.org/10.1007/978-88-470-1355-1_1

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  • DOI: https://doi.org/10.1007/978-88-470-1355-1_1

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