Skip to main content
SpringerLink
Log in

Surgical Options for Familial Adenomatous Polyposis

  • Chapter
Intestinal Polyps and Polyposis

  • 746 Accesses

Abstract

Familial adenomatous polyposis (FAP) is caused by a mutation of APC gene. The use of prophylactic surgery has significantly changed patients’ destiny, avoiding the development of colorectal cancer. It is now clear that the different patterns of FAP are based on different APC mutations. For this reason, it is important to offer a tailored approach, where the type of operation and the timing is based on aggressiveness of the disease and the risk of other manifestations such as desmoid tumors. Furthermore, it is also important to take into account the wishes and expectations of these patients. For example, we are increasingly coming across asymptomatic young women with FAP who want to have children and who are worried about the consequences of surgery for pregnancy. The decision process is not always easy, especially since there is often not a unique right answer. The final choice should often be taken by the patients, guided but not forced by the surgeon.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Vasen HFA, van Duijvendijk P, Buskens E, et al (2001) Decision analysis in the surgical treatment of patients with familial adenomatous polyposis: a Dutch-Scandinavian collaborative study including 659 patients. Gut 49:231–235.

    Article  PubMed  CAS  Google Scholar 

  2. Contessini-Avesani E, Botti F, Carrara A, et al (2006) Genetic mutations in FAP and conventional or laparoscopic surgical approach. In: Delaini GG (ed) Inflammatory bowel disease and familial adenomatous polyposis. Clinical management and patients’ quality of life. Springer, Milan Berlin Heidederlberg, New York, pp 329–344.

    Chapter  Google Scholar 

  3. Will OCC, Man RF, Phillips RKS, Tomlinson IP, Clark SK (2008) Familial adenomatous polyposis and the small bowel: a loco-regional review and current management strategies. Pathol Res Pract 204:449–458.

    Article  PubMed  CAS  Google Scholar 

  4. Ambrose WL Jr, Dozois RR, Pemberton JH, et al (1992) Familial adenomatous polyposis: results following ileal pouch-anal anastomosis and ileorectostomy. Dis Colon Rectum 35:12–15.

    Article  Google Scholar 

  5. Jagelman DG (1991) Choice of operation in familial adenomatous polyposis. World J Surg 15:47–49.

    Article  PubMed  CAS  Google Scholar 

  6. Kartheuser A (1997) Surgery, genetics and experimental models. PhD thesis, Université Catholique de Louvain, Brussels.

    Google Scholar 

  7. Kartheuser A, Stangherlin P, Brandt D, Remue C, Sempoux C (2006) Restorative proctocolectomy and ileal pouch-anal anastomosis for familial adenomatous polyposis revisited. Fam Cancer 5:241–260.

    Article  PubMed  Google Scholar 

  8. Möslein G, Pistorius S, Saeger HD, Schackert HK (2003) Preventive surgery for colon cancer in familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer syndrome. Langenbecks Arch Surg 388:9–16.

    PubMed  Google Scholar 

  9. Martin LW, LeCoultre C, Schubert WK (1977) Total colectomy and mucosal proctectomy with preservation of continence in ulcerative colitis. Ann Surg 186:477.

    Article  PubMed  CAS  Google Scholar 

  10. Fonkalsrud EW, Ament ME (1978) Endorectal mucosal resection without proctectomy as an adjunct to abdominoperineal resection for non-malignant conditions: clinical experience with five patients. Ann Surg 188:245.

    Article  PubMed  CAS  Google Scholar 

  11. Parks AG, Nicholls RJ, Belliveau P (1980) Proctocolectomy with ileal reservoir and anal anastomosis. Br J Surg 67:533.

    Article  PubMed  CAS  Google Scholar 

  12. Utsonomiya J, Iwama T, Imajo M, et al (1980) Total colectomy, mucosal proctectomy, and ileoanal anastomosis. Dis Colon Rectum 23:459.

    Article  Google Scholar 

  13. Parc YR, Radice E, Dozois RR (1999) Surgery for ulcerative colitis: historical perspective. A century of surgical innovations and refinements. Dis Colon Rectum 42:299–306.

    Article  PubMed  CAS  Google Scholar 

  14. Valiente MA, Bacon HE (1955) Construction of a pouch by using a “pantaloon ”technique for pull through of ileum following total colectomy. Am J Surg 90:742–750.

    Article  PubMed  CAS  Google Scholar 

  15. Dozois RR (1989) Technique of ileal pouch-anal anastomosis. Perspect Colon Rectal Surg 2:85–94.

    Google Scholar 

  16. Kartheuser A, Parc R, Penna C, et al (1996) Ileal pouchanal anastomosis as the first choice operation in patients with familial adenomatous polyposis. A ten year experience. Surgery 119:615–623.

    Article  PubMed  CAS  Google Scholar 

  17. Remzi F, Ooi B, Preen M, Bast J, et al (2002) Prospective evaluation of functional outcome and quality of life in over 2000 patients undergoing mucosectomy handsewn (MHS) versus stapled (STP) ileal pouch-anal anastomosis (IPAA). American Society of Colon and Rectal Surgeons: Annual Meeting 2002, poster P57

    Google Scholar 

  18. Tuckson WB, Lavery LC, Fazio VW, et al (1991) Manometric and functional comparison of ileal pouch-anal anastomosis with and without anal manipulation. Am J Surg 161:90–96.

    Article  PubMed  CAS  Google Scholar 

  19. Ooi BS, Remzi FH, Gramlich T, et al (2003) Anal transitional zone cancer after restorative proctocolectomy and ileoanal anastomosis in familial adenomatous polyposis. Dis Colon Rectum 46:1418–1423.

    Article  PubMed  Google Scholar 

  20. Deen KI, Williams JG, Grant EA, et al (1995) Randomized trial to determine the optimum level of pouch-anal anastomosis in stapled restorative proctocolectomy. Dis Colon Rectum 38:133–138.

    Article  PubMed  CAS  Google Scholar 

  21. Duff SE, O’Dwyer ST, Hulten L, et al (2002) Displasia in the ileo-anal pouch. Colorectal Dis 4:420–429.

    Article  PubMed  CAS  Google Scholar 

  22. Thompson-Fawcett MW, Mortensen NJ (1996) Anal transitional zone and columnar cuff in restorative proctocolectomy. Br J Surg 83;1947–1955.

    Article  Google Scholar 

  23. Wexner SD, Cera SM (2005) Laparoscopic surgery for ulcerative colitis. Surg Clin N Am 85:35–47.

    Article  PubMed  Google Scholar 

  24. Van Duijvendijk P, Vasen HF, Bertario L, et al (1999) Cumulative risk of developing polyps or malignancy at the ileal pouch-anal anasrtomosis in patients with familial adenomatous polyposis. J Gastrointestinal Surg 3:325–330.

    Article  Google Scholar 

  25. Dozois RR, Kelly KA, Welling DR, et al (1989) Ileal pouch-anal anastomosis: comparison of results in familial adenomatous polyposis and chronic ulcerative colitis. Ann Surg 210:268–273.

    Article  PubMed  CAS  Google Scholar 

  26. Becker JM, Stucchi AF (2004) Proctocolectomy with ileoanal anastomosis. J Gastrointestinal Surg 8:376–386.

    Article  Google Scholar 

  27. Nicholls RJ, Bartolo DC, Mortensen N (1993) Restorative proctocolectomy. Blackwell Scientific Publications, Oxford, p 166.

    Google Scholar 

  28. Gullberg K, Liljeqvist L (2001) Stapled ileoanal pouches without loop ileostomy: a prospective study in 86 patients. Int J Colorectal Dis 16:221–227.

    Article  PubMed  CAS  Google Scholar 

  29. Metcalf AM, Dozois RR, Beart RW, et al (1986) Temporary ileostomy for ileal pouch-anal anastomosis: function and complications. Dis Colon Rectum 29:30–33.

    Google Scholar 

  30. Kartheuser A, Brandt D, Detry R, et al (2003) Ileal pouchanal anstomosis: avoiding ileostomy by Riolan’s arcade preservation. Colorectal Dis 5:42.

    Google Scholar 

  31. Heuschen UA, Hinz U, Allemeyer EH, et al (2002) Risk factors for ileoanal J pouch-related septic complications in ulcerative colitis and familial adenomatous polyposis. Ann Surg 235:207–216.

    Article  PubMed  Google Scholar 

  32. Sugerman HJ, Newsome HH (1994) Stapled ileoanal anastomosis without a temporary ileostomy. Am J Surg 167:58–66.

    Article  PubMed  CAS  Google Scholar 

  33. Galandiuk S, Wolff BG, Dozois RR, Beart RW (1991) Ileal pouch-anal anastomosis without ileostomy. Dis Colon Rectum 34:870–873.

    Article  PubMed  CAS  Google Scholar 

  34. Gorfine SR, Gelernt IM, Bauer JJ, et al (1995) Restorative proctocolectomywithout diverting ileostomy. Dis Colon Rectum 38:18–94.

    Google Scholar 

  35. Grobler SP, Hosie KB, Keighley MR (1992) Randomized trial of loop ileostomy in restorative proctocolectomy. Br J Surg 79:903–906.

    Article  PubMed  CAS  Google Scholar 

  36. Cohen Z, MacLeod RS, Stephen W, et al (1992) Continuing evolution of the pelvic pouch procedure. Ann Surg 216:506–511.

    Article  PubMed  CAS  Google Scholar 

  37. Onaitis MW, Mantyh C (2003) Ileal pouch-anal anastomosis for ulcerative colitis and familial adenomatous polyposis. Historical development and current status. Ann Surg 65:S42–48.

    Google Scholar 

  38. Fazio VW, Ziv Y, Church JM, et al (1995) Ileal pouch-anal anastomosis complications and functions in 1005 patients. Ann Surg 222:120–127.

    Article  PubMed  CAS  Google Scholar 

  39. Smith L, Friend WG, Medwell SJ (1984) The superior mesenteric artery: the critical factor in the pouch pullthrough procedure. Dis Colon Rectum 27:741–744.

    Article  PubMed  CAS  Google Scholar 

  40. Martel P, Blanc P, Bothereau H, et al (2002) Comparative anatomicalstudy of division of the ileocolic pedicle or the superior mesenteric pedicle for mesenteric lengthening. Br J Surg 89:775–778.

    Article  PubMed  Google Scholar 

  41. Goes RN, Coy CS, Amaral CA, Fagundes JJ, Medeiros RR (1995) Superior mesenteric artery syndrome as a complication of ileal pouch-anal anastomosis. Dis Colon Rectum 38:543–544.

    Article  PubMed  CAS  Google Scholar 

  42. Gignoux BM, Parc R, Tiret E (2002) Ileal pouch-anal anastomosis without covering ileostomy. Gastroenterol Clin Biol 26:671–674.

    PubMed  Google Scholar 

  43. Church J, Simmang C (2003) Standards task force of the American Society of Colon and Rectal Surgeons. Practice parameters for treatment of patients with dominantly colorectal cancer (familial adenomatous polyposis and Hereditary nonpolyposis colorectal cancer). Dis Colon Rectum 46:1001–1012.

    Article  PubMed  Google Scholar 

  44. Ziv Y, Church JM, Oakley JR, McGannon E, Fazio VW (1995) Surgery for the teenager with familial adenomatous polyposis: ileorectal anastomosis or restorative proctocolectomy? Int J Colorectal Dis 10:6–9.

    Article  PubMed  CAS  Google Scholar 

  45. Church J, Burke C, MacGannon E, et al (2003) Risk of rectal cancer in patients after colectomy and ileorectal anastomosis for familial adenomatous polyposis. Dis Colon Rectum 46:1175–1181.

    Article  PubMed  Google Scholar 

  46. Bülow S, Bülow C, Vasen H, et al (2008) Colectomy and ileorectal anastomosis is still an option for selected patients with familial adenomatous polyposis. Dis Colon Rectum 51:1318–1323.

    Article  PubMed  Google Scholar 

  47. Bertario L, Sala P, Radice P, et al (2001) Ileorectal anastomosis in patients with familial adenomatous polyposis. Gastroenterology 121:502–503.

    Article  PubMed  CAS  Google Scholar 

  48. Bülow C, Vasen H, Jarvinen H, et al (2000) Ileorectal anastomosis is appropriate for a subset of patients with familial adenomatous polyposis. Gastroenterology 119:1454–1460.

    Article  PubMed  Google Scholar 

  49. Vasen HF, van der Luijt RB, Slors JF, et al (1996) Molecular genetic tests as a guide to surgical management of familial adenomatous polyposis. Lancet 348;433–435.

    Article  PubMed  CAS  Google Scholar 

  50. Nugent K, Phillips R (1992) Rectal cancer risk in older patients with familial adenomatous polyposis and an ileorectal anastomosis: a cause of concern. Br J Surg 79:1204–1206.

    Article  PubMed  CAS  Google Scholar 

  51. Friedl W, Caspari R, Sengteller M, et al (2001) Can APC mutation analysis contribute to therapeutic decision in familial adenomatous polyposis? Experience from 680 FAP families. Gut 48:515–521.

    Article  PubMed  CAS  Google Scholar 

  52. Aziz O, Athanasiou T, Fazio VW, et al (2006) Metaanalysis of observational studies of ileorectal versus ileal pouch-anal anastomosis for familial adenomatous polyposis. Br J Surg 93:407–417.

    Article  PubMed  CAS  Google Scholar 

  53. Wasmuth HH, Svinsås M, Tranø G, et al (2006) Surgical load and long-term outcome for patients with Kock continent ileostomy. Colorectal Dis 9:713–717.

    Article  Google Scholar 

  54. Boardman LA (2002) Heritable colorectal cancer syndromes: recognition and preventive management.

    Google Scholar 

  55. Wu JS, Paul P, MacGannon E, Church J (1998) APC genotype, polyp number, and the surgical options in familial adenomatous polyposis. Ann Surg 227:57–62.

    Article  PubMed  CAS  Google Scholar 

  56. Giardiello F, Krush A, Petersen G, et al (1994) Phenotypic variability of familial adenomatous polyposis in 11 unrelated families with identical APC gene mutation. Gastroenterology 106:1542–1547.

    PubMed  CAS  Google Scholar 

  57. Bertario L, Russo A, Sala P, et al (2004) APC genotype is not a prognostic factor in familial adenomatous polyposis patients with colorectal cancer. Dis Colon Rectum 47:1162–1169.

    Article  Google Scholar 

  58. Hernegger G, Harvey G, Guillem J (2002) Attenuated familial adenomatous polyposis an evolving an poorly understood entity. Dis Colon Rectum 45:127–136.

    Article  PubMed  Google Scholar 

  59. Spirio L, Olschwang S, Groden J, et al (1993) Alleles of the APC gene: an attenuated form of familial polyposis. Cell 75:951–957.

    Article  PubMed  CAS  Google Scholar 

  60. Soravia C, Berk T, Madlensky L (1998) Genotype-phenotype correlation in attenuated adenomatous polyposis coli. Am J Hum Genet 62:1290–1301.

    Article  PubMed  CAS  Google Scholar 

  61. Nieuwenhuis M, Mathus-Vliegen L, Slors F, et al (2007) Genotype-phenotype correlations as a guide in the management of familial adenomatous polyposis. Clin Gastroenterol Hepatol 374–378.

    Google Scholar 

  62. Valanzano R, Ficari F, Curia M, et al (2007) Balance between endoscopic and genetic information in the choice of ileorectal anastomosis for familial adenomatous polyposis. J Surg Oncol 95:28–33.

    Article  PubMed  CAS  Google Scholar 

  63. Church J, Burke C, MacGannon E, et al (2001) Predicting polyposis severity by proctoscopy: how reliable is it? Dis Colon Rectum 44:1249–1254.

    Article  PubMed  CAS  Google Scholar 

  64. Madden M, Neale K, Nicholls R, et al (1991) Comparison of morbidity and function after colectomy with ileorectal anastomosis or restorative proctocolectomy for familial adenomatous polyposis. Br J Surg 78:789–792.

    Article  PubMed  CAS  Google Scholar 

  65. Olsen KO, Juul S, BĂĽlow S, et al (2003) Female fecundity before and after operation for familial adenomatous polyposis. Br J Surg 90:890.

    Article  PubMed  CAS  Google Scholar 

  66. Gallagher MC, Sturt NJH, Phillipq RKS (2003) Female fecundity before and after operation for familial adenomatous polyposis. Br J Surg 90:227–231.

    Article  Google Scholar 

  67. Johansen C, Bitsch M, Bülow S (1990) Fertility and pregnancy in women with familial adenomatous polyposis. Int J Colorectal Dis 5:203–206

    Article  PubMed  CAS  Google Scholar 

  68. Gorgun E, Remzi FH, Goldberg JM, et al (2004) Fertility is reduced after restorative proctocolectomy with ileal pouch anal anastomosis: a study of 300 patients. Surgery 136:795–803.

    Article  PubMed  Google Scholar 

  69. Oresland T, Palmblad S, Ellstrom M, et al (1994) Gynaecological and sexual function related to anatomical changes in the female pelvis after restorative proctocolectomy. Int J Colorectal Dis 9:77–81.

    Article  PubMed  CAS  Google Scholar 

  70. Hahnloser D, Pemberton JH, Wolff BG, et al (2004) Pregnancy and delivery before and after ileal pouch-anal anastomosis for inflammatory bowel disease: immediate and longterm consequences and outcomes. Dis Colon Rectum 47:1127–1135.

    Article  PubMed  Google Scholar 

  71. Metcalf A, Dozois RR, Beart RW, Wolff BG (1985) Pregnancy following ileal pouch.anal anastomosis. Dis Colon Rectum 28:859–861.

    Article  PubMed  CAS  Google Scholar 

  72. Nelson H, Dozois RR, Kelly KA, et al (1989) The effect of pregnancy and delivery on the ileal-pouch-anal anastomosis functions. Dis Colon Rectum 32:384–388.

    Article  PubMed  CAS  Google Scholar 

  73. Wax JR, Pinette MG, Cartin A, Blackstone J (2003) Female reproductive health after ileal pouch anal anastomosis for ulcerative colitis. Obstet Gynecol Surv 58:270–274.

    Article  PubMed  Google Scholar 

  74. Ravid A, Richard CS, Spencer LM, et al (2002) Pregnancy, delivery and pouch function after ileal pouch-anal anastomosis for ulcerative colitis. Dis Colon Rectum 45:1283–1288.

    Article  PubMed  CAS  Google Scholar 

  75. Dozois RR, Nelson H, Metcalf AM (1993) Fonction sexuelle après anastomose iléo-anale. Ann Chir 47:1009–1013.

    PubMed  CAS  Google Scholar 

  76. Farouk R, Pemberton GH, Wolff BG, et al (2000) Functional outcomes after ileal pouch-anal anastomosis for chronic ulcerative colitis. Ann Surg 231:919–926.

    Article  PubMed  CAS  Google Scholar 

  77. Scott HJ, McLeod RS, Blair J, et al (1996) Ileal pouch-anal anastomosis: pregnancy, delivery and pouch function. Int J Colorect Dis 11:84–87.

    Article  CAS  Google Scholar 

  78. Cornish JA, Tan E, Teare J, et al (2007) The effect of restorative proctocolectomy on sexual function, urinary function, fertility, pregnancy and delivery: a systematic review. Dis Colon Rectum 50:1128–1138.

    Article  PubMed  Google Scholar 

  79. Juhasz ES, Fozard B, Dosoiz RR, Ilstrup DM, Nelson H (1995) Ileal pouch-anal anastomosis function following childbirth. An extended evaluation. Dis Colon Rectum 38:159–165.

    Article  PubMed  CAS  Google Scholar 

  80. Remzi FH, Gorgun E, Bust J, et al (2005) Vaginal delivery after ileal pouch-anal anastomosis: a word of caution. Dis Colon Rectum 48:1691–1699.

    Article  PubMed  Google Scholar 

  81. Karthauser A, Charre L, Kayser J, et al (2003) Laparoscopic restorative proctocolectomy without ileostomy. Colorectal Dis 5(suppl 2):170.

    Google Scholar 

  82. Penna C, Tiret E, Daude F, Parc R (1994) Results of ileal pouch-anal anastomosis in familial adenomatous polyposis complicated by rectal carcinoma. Dis Colon Rectum 37:157–160.

    Article  PubMed  CAS  Google Scholar 

  83. Panis Y, Bonhomme N, Hautefeuille P, Valleur P (1996) Ileal pouch-anal anastomosis with mesorectal excision for rectal cancer complicating familial adenomatous polyposis. Eur J Surg 162:817–821.

    PubMed  CAS  Google Scholar 

  84. Colwell JC, Grey M (2001) What functional outcomes and complications should be taught to the patient with ulcerative colitis or familial adenomatous polyposis who undergoes ileal pouch anal anastomosis. J Wound Ostotomy Continence Nurs 28:184–189.

    CAS  Google Scholar 

  85. Metcalf AM, Dozois RR, Kelly KA (1986) Sexual function in women after proctocolectomy. Ann Surg 204:624–627.

    Article  PubMed  CAS  Google Scholar 

  86. Tekkis PP, Fazio VW, Lavery IC, et al (2005) Evaluation of the learning curve in ileal pouch-anal anastomosis surgery. Ann Surg 241:262–268.

    Article  PubMed  Google Scholar 

  87. Ziv Y, Fazio VW, Church JM, et al (1996) Stapled ileal pouch-anal anastomoses are safer than hand-sewn anastomoses in patients with ulcerative colitis. Am J Surg 171:320–323.

    Article  PubMed  CAS  Google Scholar 

  88. Sagar PM, Lewis W, Holdsworth PJ, Johnston D (1992) One-stage restorative proctocolectomy without temporary defunctioning ileostomy. Dis Colon Rectum 35:582–588.

    Article  PubMed  CAS  Google Scholar 

  89. Fazio VW, O’Riordain MG, Lavery IC, et al (1999) Longterm functional outcome and quality of life after stapled restorative proctocolectomy. Ann Surg 230:575–586.

    Article  PubMed  CAS  Google Scholar 

  90. Meagher AP, Farouk R, Dozois RR, et al (1998) J ileal pouch-anal anastomosis for chronic ulcerative colitis: complications and long-term outcome in 1310 patients. Br J Surg 85:800–803. Gastroenterol Clin North Am 31:1107-1131.

    Article  PubMed  CAS  Google Scholar 

  91. Van Duijvendijk P, Slors F, Taat CW, et al (2000) What is the benefit or preoperative sperm preservation for patients who undergo restorative proctocolectomy for benign disease. Dis Colon Rectum 43:838–842.

    Article  PubMed  Google Scholar 

  92. Iida M, Yao T, Watanabe H, Itoh H, Iwashita A (1984) Fundic gland polyposis in patients without familial adenomatosis coli: its incidence and clinical features. Gastroenterology 876:1437–1442.

    Google Scholar 

  93. Domizio P, Talbot IC, Spigelman AD, Williams CB, Phillips RK (1990) Upper gastrointestinal pathology in familial adenomatous polyposis: results from a prospective study of 102 patients. J Clin Pathol 43:738–743.

    Article  PubMed  CAS  Google Scholar 

  94. Mabrut JY, Romagnoli R, Collard JM, et al (2006) Familial adenomatous polyposis predispodes to pathologic exposure of the stomach to bilirubin. Surgery 140:818–823.

    Article  PubMed  Google Scholar 

  95. Bertoni G, Sassatelli R, Nigrisoli E, et al (1996) Dysplastic changes in gastric fundic gland polyps of patients with familial adenomatous polyposis. Ital J Gastroenterol Hepatol 8:1201–1206.

    Article  CAS  Google Scholar 

  96. Wu TT, Kornacki S, Rashid A, Yardley JH, Hamilton SR (1998) Dysplasia and dysregulation of proliferation in foveolare and surface epithelia of fundic gland polyps from patients with familial adenomatous polyposis. Am J Surg Pathol 22:293–298.

    Article  PubMed  CAS  Google Scholar 

  97. Abraham SC, Nobukawa B, Giardiello FM, Hamilton SR, Wu TT (2000) Fundic gland polyps in familial adenomatous polyposis: neoplasms with frequent somatic adenomatous polyposis coli gene alterations. Am J Pathol 157:747–754.

    PubMed  CAS  Google Scholar 

  98. Nakamura S, Matsumoto T, Kobori Y, Iida M (2002) Impact of Helicobacter pylori infection and mucosal atrophy on gastric lesions in patients with familial adenomatous polyposis. Gut 51:485–489.

    Article  PubMed  CAS  Google Scholar 

  99. Spigelman AD, Willaims CB, Talbot IC, Domizio P, Phillips RK (1989) Upper gastrointestinal cancer in patients with familial adenomatous polyposis. Lancet 2:783–785.

    Article  PubMed  CAS  Google Scholar 

  100. Gallagher MC, Phillips RK, Bülow S (2006) Surveillance and management of upper gastrointestinal disease in familial adenomatous polyposis. Fam Cancer 5:263–273.

    Article  PubMed  Google Scholar 

  101. Wallace MH, Phillips RK (1998) Upper gastrointestinal disease in patients with familial adenomatous polyposis. Br J Surg 85:742–750.

    Article  PubMed  CAS  Google Scholar 

  102. Kashiwagi H, Spigelman AD (2000) Gastroduodenal lesions in familial adenomatous polyposis. Surg Today 30:675–682.

    Article  PubMed  CAS  Google Scholar 

  103. Nugent KP, Farmer KC, Spigelman AD, Williams CB, Phillips RK (1993) Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis. Br J Surg 80:1618–1619.

    Article  PubMed  CAS  Google Scholar 

  104. Richard CS, Berk T, Bapat BV, et al (1997) Sulindac for periampullary polyps in FAP patients. Int J Colorectal Dis 12:14–18.

    Article  PubMed  CAS  Google Scholar 

  105. Phillips RK, Wallace MH, Lynch PM, et al (2002) A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor on duodenal polyposis in familial adenomatous polyposis. Gut 5:857–860.

    Article  Google Scholar 

  106. Bertoni G, Sassatelli R, Nigrisoli E, et al (1996) High prevalence of adenomas and microadenomas of the duodenal papilla and periampullary region in patients with familial adenomatous polyposis. Eur J Gastroenterol Hepatol 8:1201–1206.

    Article  PubMed  CAS  Google Scholar 

  107. Church JM, McGannon E, Hull-Boiner S, et al (1992) Gastroduodenal polyps in patients with familial adenomatous polyposis. Dis Colon Rectum 35:1170–1173.

    Article  PubMed  CAS  Google Scholar 

  108. Murakami Y, Uemura K, Hayashidani Y, Sudo T, Sueda T (2006) Relapsing acute pancreatitis due to ampullary adenoma in a patient with familial adenomatous polyposis. J Gastroenterol 41:798–801.

    Article  PubMed  Google Scholar 

  109. Burke CA, Beck GJ, Church JM, Van Stolk RU (1999) The natural history of untreated duodenal and ampullary adenomas in patients with familial adenomatous polyposis followed in an endoscopic surveillance program. Gastrointest Endosc 49:358–364.

    Article  PubMed  CAS  Google Scholar 

  110. Matsumoto T, Iida M, Nakamura S, et al (2000) Natural history of ampullary adenoma in familial adenomatous polyposis:reconfirmation of benign nature during extended surveillance. Am J Gastroenterol 95:1557–1562.

    Article  PubMed  CAS  Google Scholar 

  111. Iizuka T, Sawada K, Hayakawa K, et al (2002) Successful local excision of ileostomy adenocarcinoma after colectomy for familial adenomatous polyposis: report of a case. Surg Today 32:638–641.

    Article  PubMed  Google Scholar 

  112. Quah HM, Samad A, Maw A (2005) Ileostomy carcinomas a review: the latent risk after colectomy for ulcerative colitis and familial adenomatous polyposis. Colorectal Dis 7:538–544.

    Article  PubMed  CAS  Google Scholar 

  113. Remzi FH, Church JM, Bast J, et al (2001) Mucosectomy vs stapled ileal pouch-anal anastomosis in patients with familial adenomatous polyposis: functional outcome and neoplasia control. Dis Colon Rectum 44;1590–1596.

    Article  PubMed  CAS  Google Scholar 

  114. Malassagne B, Penna C, Parc R (1995) Adenomatous polyps in the anal transitional zone after ileal pouch-anal anastomosis for familial adenomatous polyposis: treatment by transanal mucosectomy and ileal pouch advancement. Br J Surg 82:1634.

    Article  PubMed  CAS  Google Scholar 

  115. Tulchinsky H, Keidar A, Strul H, et al (2005) Extracolonic manifestations of familial adenomatous polyposis after proctocolectomy. Arch Surg 140:159–163.

    Article  PubMed  Google Scholar 

  116. Parc YR, Olschwang S, Desaint B, et al (2001) Familial adenomatous polyposis: prevalence of adenomas in the ileal pouch after restorative proctocolectomy. Ann Surg 233:360–364.

    Article  PubMed  CAS  Google Scholar 

  117. Parc Y, Piquard A, Dozois RR, Parc R, Tiret E (2004) Long-term outcome of familial adenomatous polyposis patients after restorative proctocolectomy. Ann Surg 239:378–382.

    Article  PubMed  Google Scholar 

  118. Polese L, Keighley MR (2003) Adenomas at resection margins do not influence the long-term development of pouch polyps after restorative proctocolectomy for familial adenomatous polyposis. Am J Surg 186:32–34.

    Article  PubMed  Google Scholar 

  119. Thompson-Fawcett MW, Marcus VA, Redston M, Cohen Z, McLeod RS (2001) Adenomatous polyps develop commonly in the ileal pouch of patients with familial adenomatous polyposis. Dis Colon Rectum 44:347–353.

    Article  PubMed  CAS  Google Scholar 

  120. Wu JS, McGannon EA, Church JM (1998) Incidence of neoplastic polyps in the ileal pouch of patients with familial adenomatous polyposis after restorative proctocolectomy. Dis Colon Rectum 41:552–556.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery and Gastroenterology, University of Verona, Verona, Italy

    Gian Gaetano Delaini MD, Chiara Zugni MD, Tania Magro MD, Filippo Nifosì MD, Maurizio Mainente MD & Gianluca Colucci MD

Authors
  1. Gian Gaetano Delaini MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chiara Zugni MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tania Magro MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Filippo Nifosì MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Maurizio Mainente MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Gianluca Colucci MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Surgery and Gastroenterology, University of Verona, Verona, Italy

    Gian Gaetano Delaini

  2. Department of Surgery, Masaryk Memorial Cancer Institute, Brno, Czech Republic

    Tomáš Skřička

  3. Department of Surgery and Gastroenterology, University of Verona, Verona, Italy

    Gianluca Colucci

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag Italia

About this chapter

Cite this chapter

Delaini, G.G., Zugni, C., Magro, T., Nifosì, F., Mainente, M., Colucci, G. (2009). Surgical Options for Familial Adenomatous Polyposis. In: Delaini, G.G., Skřička, T., Colucci, G. (eds) Intestinal Polyps and Polyposis. Springer, Milano. https://doi.org/10.1007/978-88-470-1124-3_15

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-1124-3_15

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1123-6

  • Online ISBN: 978-88-470-1124-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation