Hydrogels pp 79-96 | Cite as

Poloxamine Hydrogels: from low Cell Adhesion Substrates to Matrices with Improved Cytocompatibility for Tissue Engineering Applications

  • Alejandro Sosnik
  • Omar F. Khan
  • Mark Butler
  • Michael V. Sefton


Polyethylene glycol based hydrogels are being considered as tissue substitutes. Here we describe the preparation of synthetic collagen-mimetic material that are stirrer than collagen but that like collagen allow for both cell encapsulation and cell growth on the surface. These materials are poloxamine based hydrogels with and without collagen; poloxamine is a four-arm PEO-PPO block copolymer derivative, Tetronic™ 107.


Tissue Engineering HepG2 Cell Biomed Mater Cell Encapsulation Multiblock Copolymer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia, Milan 2009

Authors and Affiliations

  • Alejandro Sosnik
    • 1
  • Omar F. Khan
    • 1
  • Mark Butler
    • 1
  • Michael V. Sefton
    • 1
  1. 1.Institute of Biomaterials and Biomedia EngineeringUniversity of TorontoCanada

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