Hydrogels are widely used in medicine and offer advantages in many implant situations. However, the body responds to them as with any other material — by walling them off in a foreign body capsule. We show here that by making hydrogels with uniform, interconnected spherical pores of about 35 microns, the healing reaction can be shifted to one of vascularization and little fibrosis. We have also developed a biodegradable form of poly(2-hydroxyethyl methacrylate) that can be used to fabricate these pro-healing, spherically pored materials.
KeywordsAtomic Radical Transfer Polymerization Foreign Body Reaction Biomed Mater PMMA Microsphere Biodegradable Hydrogel
Unable to display preview. Download preview PDF.
- Atzet S, Curtin S, Trinh P, Bryant S, Ratner B (2008) Degradable poly(2-hydroxyethyl methacrylate)-co-polycaprolactone hydrogels for tissue engineering scaffolds. Biomacromolecules, doi: 10.1021/bm800686hGoogle Scholar
- Brand KG, Buoen LC, Johnson KH, Brand I (1975) Etiological factors, stages and the role of the foreign body in foreign body tumorigenesis: a review. Cancer Res 35:279–286Google Scholar
- Picha GJ, Siedlak DJ (1984) Ion-beam microtexturing of biomaterials. MD & DI 6(4): 39–42Google Scholar
- Clowes AW, Kirkman TR, Reidy MA (1986) Mechanisms of arterial graft healing-rapid transmural capillary ingrowth provides a source of intimal endothelium and smooth muscle in porous PTFE prostheses. Am J Path 123(2):220–230Google Scholar
- Marshall AJ, Irvin CA, Barker T, Sage EH, Hauch KD, Ratner BD (2004) Biomaterials with tightly controlled pore size that promote vascular in-growth. ACS Polymer Preprints 45(2): 100–101Google Scholar